Cadexomer iodine in ulcers colonised by Pseudomonas aeruginosa

Danielsen, L; Cherry, George W.; Harding, KG; Rollman, Ola

doi:10.12968/jowc.1997.6.4.169

Cited by 34 publications

(21 citation statements)

References 6 publications

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“…These include: collagens, hydrofibres, antimicrobial dressings, debriding agents, odour‐absorbing dressings, biosynthetic dressings and hyaluronic acid dressings (17). Among them, a slow‐release iodine preparation, cadexomer iodine, has been demonstrated to be useful for chronic venous ulcers (18–22), diabetic foot ulcers (23), decubitus ulcers (24) and infected wounds (25,26). Cadexomer iodine is composed of starch cross‐linked with ether bridges and iodine.…”

Section: Discussionmentioning

confidence: 99%

Cadexomer as well as cadexomer iodine induces the production of proinflammatory cytokines and vascular endothelial growth factor by human macrophages

Ohtani

Mizuashi

Ito

et al. 2007

Experimental Dermatology

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Although cadexomer iodine is widely used for the treatment of skin ulcers such as decubitus ulcers, the mechanism by which it enhances wound healing is not clear. Recently, it has been demonstrated that macrophages play an important role in wound healing by inducing inflammation and angiogenesis. We examined the effects of cadexomer and cadexomer iodine on tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6, IL-8, IL-10, IL-12 p 40, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) production by macrophages. Human macrophages were obtained by culturing CD14+ monocytes with macrophage colony stimulating factor (M-CSF) in the presence or absence of cadexomer or cadexomer iodine. The production of cytokines and the expression of mRNA were evaluated by enzyme linked immunosorbent assay (ELISA) of the culture supernatants and by reverse transcriptase polymerase chain reaction (RT-PCR) analysis, respectively. In addition, we examined the tissue concentration of VEGF in the wounds treated with or without cadexomer iodine. Cadexomer and cadexomer iodine significantly increased the expression of IL-1 beta, IL-8, TNF-alpha and VEGF mRNA, while they did not affect that of IL-6, IL-10, IL-12 p 40 or bFGF mRNA. In addition, they significantly increased the production of IL-1 beta and TNF-alpha. Although we could not detect increased production of VEGF in the culture supernatants, the western blot analysis of macrophages demonstrated the increased production of VEGF by the treatment with either cadexomer or cadexomer iodine. The treatment with cadexomer iodine increased the tissue concentration of VEGF in the skin wounds. These data suggest that cadexomer and cadexomer iodine have beneficial effects on wound healing in addition to those related to their antibacterial activity.

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Section: Discussionmentioning

confidence: 99%

Cadexomer as well as cadexomer iodine induces the production of proinflammatory cytokines and vascular endothelial growth factor by human macrophages

Ohtani

Mizuashi

Ito

et al. 2007

Experimental Dermatology

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“…An in vitro study63 showed no toxicity of cadexomer iodine to human cells at concentration of 0.45% (weight per volume, w/v). Nevertheless, this iodophor was found to reduce the numbers of S aureus 64,65 and capture different microorganisms onto cadexomer iodine 63…”

Section: Methodsmentioning

confidence: 99%

A Comprehensive Review of Topical Odor-Controlling Treatment Options for Chronic Wounds

Akhmetova

Saliev

Allan

et al. 2016

Journal of Wound, Ostomy &Amp; Continence Nursing

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The process of wound healing is often accompanied by bacterial infection or critical colonization, resulting in protracted inflammation, delayed reepithelization, and production of pungent odors. The malodor produced by these wounds may lower health-related quality of life and produce psychological discomfort and social isolation. Current management focuses on reducing bacterial activity within the wound site and absorbing malodorous gases. For example, charcoal-based materials have been incorporated into dressing for direct adsorption of the responsible gases. In addition, multiple topical agents, including silver, iodine, honey, sugar, and essential oils, have been suggested for incorporation into dressings in an attempt to control the underlying bacterial infection. This review describes options for controlling malodor in chronic wounds, the benefits and drawbacks of each topical agent, and their mode of action. We also discuss the use of subjective odor evaluation techniques to assess the efficacy of odor-controlling therapies. The perspectives of employing novel biomaterials and technologies for wound odor management are also presented.

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“…For example, it has been demonstrated that honey affects differently each bacterial strain, thus preventing the development of resistance [35]. Iodine [36], sugar [30,32] or silver [18,[37][38][39] have also been widely used for antibacterial purposes.…”

Section: Wound Healing and Its Mechanismmentioning

confidence: 99%

Current state of chronic wound care in Kazakhstan: focus on topical treatments

Akhmetova¹,

Saliev²,

Kulsharova³

et al. 2015

RusOMJ

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Background -The presence of chronic hard-to-heal wounds significantly affects patients' quality of life causing pain, discomfort, decrease of mobility and consequently leads to social isolation and depression. This type of wound is more prevalent among older population. It has been estimated that up to 1-2% of the world population have this condition. The treatment of hard-to-heal wounds is expensive and long-term process, and, stresses healthcare systems of every country. Unfortunately, limited information is available about the situation with chronic wounds in Kazakhstan as the statistical data on such patients is not monitored and not registered in this country. Methods -The search was conducted by using available electronic sources, including Google Scholar, PubMed, Web of Sciences, Medline, Wiley Online Library, and Cochrane Library databases as well as hard copy versions of peer-reviewed publications in Russian, Kazakh, and English languages. Results -We have identified and analyzed current situation with wound care in the Republic of Kazakhstan. Research has demonstrated a variety of types of treatments utilized in the country, particularly the treatment of the diabetic foot.It also indicates the lack of statistics on wound care. Conclusions -The review highlights the mechanisms of wound healing process, methods for wound care, and encompasses the information available on wound healing in Republic of Kazakhstan. The article emphasizes the necessity of establishing the systemic monitoring of wound care and formation of electronic database. Apart from that, the importance of developing and manufacturing of domestic novel wound treatments have been also stressed out.

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Cadexomer iodine in ulcers colonised by Pseudomonas aeruginosa

Cited by 34 publications

References 6 publications

Cadexomer as well as cadexomer iodine induces the production of proinflammatory cytokines and vascular endothelial growth factor by human macrophages

Cadexomer as well as cadexomer iodine induces the production of proinflammatory cytokines and vascular endothelial growth factor by human macrophages

A Comprehensive Review of Topical Odor-Controlling Treatment Options for Chronic Wounds

Current state of chronic wound care in Kazakhstan: focus on topical treatments

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