Caddis Fly Allergy in a Hydroelectric Plant Worker, a Classic Association

Abstract

RATIONALE: The interaction between chronic inflammation and neural dysfunction points to an involvement linking the nervous and the immune system in the airways. In particular, environmental exposure to nanoparticles has been associated with an enhanced risk of asthma. But the impact of nanoparticles on neurogenic mechanism remains to be determined. The aim of this study was to identify the impact of nanoparticles on neuro inflammation in a mouse model of allergic asthma. METHODS: Using mice sensitized with ovalbumin (OVA) and OVA challenged (OVA sensitized/challenged mice) as well as mice treated with saline and challenged with air, and mice exposed to nanoparticles 200 ug/m 3 on days 21-23. The effect of nanoparticles on P2X3, TRPV1, and neuropeptides was estimated using ELISA, immunoblotting, and immunohistochemical stain. RESULTS: Nanoparticles exposure more increased in airway inflammation, and airway obstruction in OVA mice, and those were augumented in nanoparticles exposed mice. TRPV1 protein increased and P2X3 protein decreased in OVA and nanoparticles exposed mice. Substance P, ATP, and CGRP increased in BAL fluid of OVA and nanoparticles exposed mice. CONCLUSIONS: These results indicate that nanoparticles might be involved in the pathogenesis of bronchial asthma through neurogenic mechanism.

Arthropod Allergy and Public Health

“…Adult caddisflies are attracted to both UV and visible spectrums (Kimura and Kuranishi 2020). These flies are sucked into and pulverised by the power turbines and dispersed as aeroallergens (Kraut et al 1994;Miedinger et al 2010;McNulty and Divekar 2017). A recent study has reported that professional cleaning workers exhibit airway inflammation and hypersensativity to caddis fly allergens (Lima et al 2017).…”