Cadaveric allograft as adjunct therapy for nonhealing ulcers

Snyder, Robert J.; Simonson, David A.

doi:10.1016/s1067-2516(99)80019-2

Cited by 17 publications

(2 citation statements)

References 20 publications

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“…The type of storage facilities required also presented an obstacle. Based on the plethora of past studies involving allograft, most authors recommend its use and find it an adjuvant to ‘jump start’ the wound bed granulation and epithelialisation (3,12,13). Xenografts from multiple species have been used clinically; however, the sterility is questionable.…”

Section: Gamma‐irradiated Skin Graftsmentioning

confidence: 99%

Gamma‐irradiated human skin allograft: a potential treatment modality for lower extremity ulcers

Rosales

Bruntz

Armstrong

2004

International Wound Journal

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Gamma-irradiated human skin allograft consists of epidermis and dermis. Unlike bioengineered tissues which require cold storage and timely use once received from the manufacturer, gamma-irradiated human skin allograft can be stored for as long as 24 months at room temperature. This modality is applied in a fashion similar to that of bioengineered skin grafts. In this article, we present case studies with concise reviews of the available evidence to discuss the potential use of gamma-irradiated human skin allograft on wounds in the lower extremity.

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Section: Gamma‐irradiated Skin Graftsmentioning

confidence: 99%

Gamma‐irradiated human skin allograft: a potential treatment modality for lower extremity ulcers

Rosales

Bruntz

Armstrong

2004

International Wound Journal

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“…Skin grafts are the most obvious therapeutic approach for replacing the lost tissue of skin ulcers. Cadaveric cryopreserved skin allografts can be used to stimulate healing, particularly for deep wounds with exposed bones and tendons ( Snyder and Simonson, 1999 ). Besides creating a temporary barrier, they act by stimulating re-epithelialization and granulation tissue formation; however, a retrospective comparative analysis on the effectiveness of cadaveric skin allograft against bioengineered living cell constructs revealed that living cells manifest better performance ( Treadwell et al, 2018 ).…”

Section: Innovative Therapies For Diabetic Foot Ulcersmentioning

confidence: 99%

Innovative Cell and Platelet Rich Plasma Therapies for Diabetic Foot Ulcer Treatment: The Allogeneic Approach

Mastrogiacomo

Nardini

Collina

et al. 2022

Front. Bioeng. Biotechnol.

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Cutaneous chronic wounds are a major global health burden in continuous growth, because of population aging and the higher incidence of chronic diseases, such as diabetes. Different treatments have been proposed: biological, surgical, and physical. However, most of these treatments are palliative and none of them can be considered fully satisfactory. During a spontaneous wound healing, endogenous regeneration mechanisms and resident cell activity are triggered by the released platelet content. Activated stem and progenitor cells are key factors for ulcer healing, and they can be either recruited to the wound site from the tissue itself (resident cells) or from elsewhere. Transplant of skin substitutes, and of stem cells derived from tissues such as bone marrow or adipose tissue, together with platelet-rich plasma (PRP) treatments have been proposed as therapeutic options, and they represent the today most promising tools to promote ulcer healing in diabetes. Although stem cells can directly participate to skin repair, they primarily contribute to the tissue remodeling by releasing biomolecules and microvesicles able to stimulate the endogenous regeneration mechanisms. Stem cells and PRP can be obtained from patients as autologous preparations. However, in the diabetic condition, poor cell number, reduced cell activity or impaired PRP efficacy may limit their use. Administration of allogeneic preparations from healthy and/or younger donors is regarded with increasing interest to overcome such limitation. This review summarizes the results obtained when these innovative treatments were adopted in preclinical animal models of diabetes and in diabetic patients, with a focus on allogeneic preparations.

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Skin: Specific Recovery and Processing Issues

Pianigiani

Pierce²

2012

Tissue and Cell Processing

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Cadaveric allograft as adjunct therapy for nonhealing ulcers

Cited by 17 publications

References 20 publications

Gamma‐irradiated human skin allograft: a potential treatment modality for lower extremity ulcers

Gamma‐irradiated human skin allograft: a potential treatment modality for lower extremity ulcers

Innovative Cell and Platelet Rich Plasma Therapies for Diabetic Foot Ulcer Treatment: The Allogeneic Approach

Skin: Specific Recovery and Processing Issues

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