CADASIL and migraine: A narrative review

Liem, Michael; Oberstein, Saskia A J Lesnik; Grond, Jeroen van der; Ferrari, Michel D.; Haan, Joost

doi:10.1177/0333102410370870

Cited by 64 publications

(57 citation statements)

References 63 publications

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“…A higher prevalence of migraine in CADASIL was also reported in other studies, although not significantly [38]. A higher degree of cognitive impairment and cerebral atrophy was also noticed in men at the late stage of the disease [36,37].…”

Section: Discussionsupporting

confidence: 54%

Clinical and Radiological Features in CADASIL and NOTCH3-Negative Patients: A Multicenter Study from Turkey

İnce

Benbir²,

Síva³

et al. 2014

Eur Neurol

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Background: The diversity of clinical presentation and neuroimaging findings of CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) from different regions of the world has not yet been studied in depth. Here we investigated the variability of clinical, radiological and genetic data of 48 patients analyzed for NOTCH3 mutation in Turkey. Methods: Clinical evaluation was made according to a preformed questionnaire. Cranial neuroimaging findings were determined on the basis of T1, T2, FLAIR and proton-density magnetic resonance scans. For genetic analysis, polymerase chain reaction was performed with primers flanking exons 2-6 and 11 of NOTCH3 gene. Results: Twenty-five patients (52.1%) were diagnosed as CADASIL with NOTCH3 mutation, while 23 patients (47.9%) had no mutation (NOTCH3-negative patients). The mean age and age at stroke onset were lower in male CADASIL patients (p < 0.03). A family history of migraine (p = 0.012), stroke (p < 0.001), recurrent strokes (p = 0.020) and dementia (p = 0.012) was more common in CADASIL patients. Temporal pole involvement was more common in CADASIL patients (p = 0.004). Conclusion: It is of clinical importance to identify the heterogeneity of CADASIL from different countries due to a low correlation of clinical and radiological data with respect to NOTCH3 mutation.

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Section: Discussionsupporting

confidence: 54%

Clinical and Radiological Features in CADASIL and NOTCH3-Negative Patients: A Multicenter Study from Turkey

İnce

Benbir²,

Síva³

et al. 2014

Eur Neurol

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“…Five of our patients had migraine, two with and three without aura. Our series supports findings reporting that migraine without aura frequency is slightly higher in CADASIL patients compared with the general population 11 . Increased risk of ICH in CADASIL patients is based on case reports and it has not been proved with controlled studies.…”

supporting

confidence: 93%

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in Argentina

Hawkes

Wilken

Bruno

et al. 2015

Arq. Neuro-Psiquiatr.

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CADASIL is the most common cause of hereditary stroke and vascular dementia. Published information about this disease in South America is scant. We describe clinical and demographic characteristics of 13 patients (10 families) with CADASIL from Argentina.Methods Medical records, diagnostic tests and family history of patients with CADASIL were reviewed.Results Thirteen patients with CADASIL (10 families) were included. All patients had European ancestry. Initial presentation was stroke in most patients (n = 11). Stroke patients later developed cognitive complaints (n = 9), migraine with aura (n = 1), apathy (n = 4) and depression (n = 6). External capsule and temporal lobe involvement on MRI were characteristic imaging findings. Two patients died after intracerebral hemorrhage.Conclusion This is the first report of non-related patients with CADASIL in South America addressing ancestry. Since European ancestry is not highly prevalent in all South American countries, there may be variable incidence of CADASIL within this region.

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“…When the results are pooled, the overall prevalence of migraine in all CADASIL studies is 38 % with a 95 % CI 33-42 %. The migraine prevalence in CADASIL was higher in females than in males, but this difference did not reach statistical significance [12]. The percentage of migraine with aura could only be inferred from two of the larger study [9,10], which showed that the majority (80-90 %) of migraneurs with CADASIL have migraine with aura.…”

Section: Genetic Vasculopathiesmentioning

confidence: 90%

“…The prevalence of migraine in CADASIL ranges from 14 to 72 % in European studies [9][10][11]. The four studies from Asian countries [12] found a low migraine prevalence of 5 %. When the results are pooled, the overall prevalence of migraine in all CADASIL studies is 38 % with a 95 % CI 33-42 %.…”

Section: Genetic Vasculopathiesmentioning

confidence: 99%

Migraine and small vessel diseases

Agostoni

Rigamonti

2012

Neurol Sci

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It is remarkable that migraine is a prominent part of the phenotype of several genetic vasculopathies affecting small cerebral vessels, including cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, retinal vasculopathy with cerebral leukodystrophy and hereditary infantile hemiparesis, retinal arteriolar tortuosity and leucoencephalopathy. Moreover, several studies have reported an association between migraine and white matter lesions or clinically silent infarct-like abnormalities in the posterior circulation. In this review, we focus on genetic vasculopathies associated with migraine and speculate about the pathophysiological mechanism that can explain this comorbidity.

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CADASIL and migraine: A narrative review

Cited by 64 publications

References 63 publications

Clinical and Radiological Features in CADASIL and <b><i>NOTCH3</i></b>-Negative Patients: A Multicenter Study from Turkey

Clinical and Radiological Features in CADASIL and <b><i>NOTCH3</i></b>-Negative Patients: A Multicenter Study from Turkey

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in Argentina

Migraine and small vessel diseases

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