Cadamba : A miraculous tree having enormous pharmacological implications

Dwevedi, Alka; Sharma, Kuldeep; Sharma, Yogesh Kumar

doi:10.4103/0973-7847.162110

Cited by 50 publications

(34 citation statements)

References 23 publications

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“…The species has been taxonomically described as distinct species by earlier workers. 30 The root finds its application in several other traditional and folklore systems of medicine around the globe that have been previously described and surprisingly no pharmacopoeial standards are available for them in the literature. Owing to its importance in applications, the present study was designed and conducted.…”

Section: Discussionmentioning

confidence: 99%

Pharmacognostic Studies on the Root of Anthocephalus cadamba (Roxb.) Miq.

Acharyya¹,

Padhy²,

Dash³

2018

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Pharmacognostic Studies on the Root of Anthocephalus cadamba (Roxb.) Miq.ABSTRACT Purpose: To undertake the pharmacognostic studies of Anthocephalus cadamba (Roxb.) Miq. Root for the purpose of identification and differentiation from related species. Methods: The macroscopic and microscopic features of the root were studied, including the use of powder microscopy with the aid of suitable tools and reagents. Physicochemical parameters such as ash value, extractive value and weight loss on drying were also determined. The root powder was successively extracted with different solvents followed by preliminary phytochemical screening of the extracts. Results: Macro-and micro-scopic studies revealed cork i.e. the layer of periderm present above the cortex along with lenticels. The periderm is many layered membranous with irregularly fissured crevices containing phellum and phellogen. Secondary phloem is comparatively massive without lignified tissues i.e. bast fibres and contains sieve tubes, phloem parenchyma, many enriched with starch grains. The secondary xylem lignified mingled with medullary rays, vessels, parenchyma and wood fibers. Preliminary phytochemical screening of different extracts revealed the presence of alkaloids, carbohydrate, protein, gum, steroid, tri-terpenoid, saponin, flavonoid and tannin in the root. Conclusion: The findings of this study facilitate pharmacognostic standardization of the plant material and add clues in the preparation of herbal monographs for Phyto pharmacopeia.

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Section: Discussionmentioning

confidence: 99%

Pharmacognostic Studies on the Root of Anthocephalus cadamba (Roxb.) Miq.

Acharyya¹,

Padhy²,

Dash³

2018

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“…It has the largest number of phytochemicals and secondary metabolites (viz., cadambagenic acid, cadamine, quinovic acid, β-sitosterol, cadambine, etc.) having various biological and pharmacological properties 12 . Neolamarckia cadamba has a wide spectrum of biological activities including anti-inflammatory 13 , anti-helminthic 14 , antioxidant 15 , and antihepatotoxic activities 16 .…”

Section: Introductionmentioning

confidence: 99%

Immunomodulating potential of Neolamarckia cadamba (Roxb.) Bark extract

Khandelwal¹,

Choudhary²

2020

J. Pure Appl. Microbiol.

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Neolamarckia cadamba (Roxb.) Bosser Miq., holistic tree, well narrated in Charak Samhita and Sushrut Samhita. Traditionally different parts of N. cadamba has been used by many communities and tribes to treat sour throat, cough, fever, infections and inflammation. Present work concern with study of immunomodulatory activities of hydro-methanolic extract (HME) of N. cadamba bark with reference to humoral and cell mediated immune responses of experimental animals. On the basis of mean body weight (g) of Wistar albino rats, their healthy status, change in their behavior, skin and fur texture, four groups-Group-I (control), Group-II (125 mg/kg HME), Group-III (250 mg/kg HME) and Group-IV (500 mg/kg HME) containing six animals each were made to determine mean serum antibody titer of treated and control groups against Salmonella typhimurium 'O' antigen using indirect ELISA. Determination of in vitro cell mediated immune response was done by MTT assay using optimum concentration (5 µg/mL) Con A with various concentration of HME (20-500 µg/mL). Result suggested various doses of HME (125/250/500 mg/kg b.wt) causes significant increase (p < 0.01) in antibody titer when compared to the control group, which concludes enhanced humoral immune response. Result suggested that different concentrations of HME bring about significant increase (p < 0.01) in proliferation of splenocytes, depicting enhanced cell mediated immune response. Study concludes immunostimulatory potential of HME of N. cadamba bark and can be possibly used in drug and food preparation.

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“…Some notable examples are ajmalicine, a hypertensive drug from Catharanthus roseus and Rauwolfia serpentine ; ajmaline, an antiarrhythmic drug from R. serpentine ; yohimbine, an adrenergic receptor blocker, extracted from bark of Pausinystalia johimbe and vincristine and vinblastine, anticancer drugs from C. roseus . Anthocephalus cadamba, a medicinal plant of the Rubiaceae family, widely distributed in Nepal, Bangladesh, India, Sri Lanka, Burma, China, Thaïland and eastward through Malaysia to New Guinea, is a rich source of monoterpene indole alkaloids . A. cadamba had been used from ancient times in traditional systems of medicine for the treatment of many ailments such as fever, anemia, uterine‐complaints, blood diseases, skin diseases, leprosy, wound healing, diabetes mellitus, diarrhea, cough, inflammation, haemoptysis, vomiting, malaria and debility .…”

Section: Introductionmentioning

confidence: 99%

Monoterpene Indole Alkaloids from Anthocephalus cadamba Fruits Exhibiting Anticancer Activity in Human Lung Cancer Cell Line H1299

Mishra¹,

Khan

Yadav

et al. 2018

ChemistrySelect

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Two new monoterpene indole alkaloids, Vincosamide‐N‐oxide (1) and isodihydroamino cadambine (2) along with seven known alkaloids and triterpenoids vincosamide (3), vallesiachotamine (4), iso‐vallesiachotamine (5), dihydrocadambine (6), cadambine (7), ursolic acid (8) and oleanolic acid (9) were isolated from the fruits of Anthocephalus cadamba (Roxb) Miq. (Family: Rubiaceae). The chemical structures of the isolated molecules were determined using a combination of InfraRed (IR) and one dimensional (1D) and two dimensional (2D) Nuclear Magnetic Resonance (NMR) spectroscopy and High Resolution‐Electronspray Ionisation Mass Spectrometry (HR‐ESIMS). The molecules were evaluated for their in‐vitro antiproliferative activity against human lung cancer cell line H1299. Cytotoxic profile was studied in mouse macrophage RAW 264.7 cell line and induction of apoptosis in MCF‐7 cells. Compounds 4 and 5 were found to exhibit potent anticancer activity with IC50 values of 4.24 and 3.79 μM respectively. Both compounds demonstrated significant fragmentation in the chromatin within the nucleus cells as a result of apoptosis. In addition none of the purified compounds showed any toxic effect on normal cells.

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Cadamba : A miraculous tree having enormous pharmacological implications

Cited by 50 publications

References 23 publications

Pharmacognostic Studies on the Root of Anthocephalus cadamba (Roxb.) Miq.

Pharmacognostic Studies on the Root of Anthocephalus cadamba (Roxb.) Miq.

Immunomodulating potential of Neolamarckia cadamba (Roxb.) Bark extract

Monoterpene Indole Alkaloids from Anthocephalus cadamba Fruits Exhibiting Anticancer Activity in Human Lung Cancer Cell Line H1299

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