CAD Is an Independent Risk Factor for Stroke Among Patients With Atrial Fibrillation

Steensig, Kamilla; Olesen, Kevin Kris Warnakula; Thim, Troels; Nielsen, Jens Cosedis; Jensen, Svend Eggert; Jensen, Lisette Okkels; Kristensen, Steen Dalby; Bøtker, Hans Erik; Lip, Gregory Y.H.; Mæng, Michael

doi:10.1016/j.jacc.2018.08.1046

Cited by 20 publications

(11 citation statements)

References 3 publications

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“…Coronary computed tomographic angiography was performed using a 320-detector row computed tomography scanner (Aquilion ONE; Toshiba Medical Systems, Otawara, Japan). The CAD diagnostic criterion [ 14 ] was ≥50% stenosis by coronary computed tomographic angiography in the left main, left anterior descending, left circumflex, right coronary, or main branch. The non-CAD diagnostic criterion was without stenosis or stenosis <50% in the left main, left anterior descending, left circumflex, right coronary, or main branch lumen.…”

Section: Methodsmentioning

confidence: 99%

Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease

Liu

Shan

et al. 2020

Coronary Artery Disease

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Background: Lymphocyte-to-monocyte ratio (LMR) is involved in all stages of coronary atherosclerosis and related to coronary artery disease (CAD). However, the correlation between LMR and the coronary plaque burden of CAD is not clearly elucidated. Therefore, this study aimed to investigate their correlation in patients with CAD. Methods: A total of 1953 consecutive eligible inpatients with suspected CAD were retrospectively included in this study. They were assigned into CAD (n = 564) and non-CAD groups (n = 1389). All patients underwent coronary computed tomographic angiography to evaluate coronary stenosis and coronary artery calcification (CAC). Spearman’s tests were used to analyze the correlation between CAC score and LMR. Multivariate logistic regression models were set up to assess the risk factors of CAD. Results: Patients with CAD had lower LMR value than patients without CAD ( P = 0.001). LMR was negatively correlated with CAC score and was an independent risk factor of CAC score ( P < 0.05). Multivariate logistic regression model showed that LMR ≤4.8 was a newly independent risk factor of CAD (all P < 0.05). Additionally, the new risk score model was compared with the Framingham model and showed that NRI was 4.9%, which proved that the new risk score model improved the prediction capability of CAD. Conclusion: LMR ≤4.8 is a new independent risk factor of CAD. LMR value was negatively correlated with CAC score and could be used as a new marker to evaluate the coronary plaque burden of CAD.

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Section: Methodsmentioning

confidence: 99%

Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease

Liu

Shan

et al. 2020

Coronary Artery Disease

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“…In a large cohort study using the Danish National Patient Registry, coronary artery disease (defined as obstructive (≥50%) coronary stenosis in ≥1 coronary vessel or non-obstructive coronary stenosis in ≥2 coronary vessels) conferred a 29% increased risk of ischemic stroke, TIA or thromboembolism among patients with AF suggesting that coronary artery disease (CAD) was an independent risk factor for ischemic stroke hence the recommendation to include this component in stroke risk scores among AF patients [62].…”

Section: Vascular Diseasementioning

confidence: 99%

Stroke risk stratification in atrial fibrillation: a review of common risk factors

Oladiran

Nwosu

2019

Journal of Community Hospital Internal Medicine Perspectives

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Atrial Fibrillation (AF) has become a major global health concern being the most common sustained arrhythmia in clinical practice. Risk factors for AF include congestive heart failure, hypertension, increasing age and diabetes. Many of these factors also increase the risk for thromboembolism and ischemic stroke in AF patients. Great efforts have been made from the latter part of the 20 th century towards developing an ideal stroke risk stratification tool in AF with the aim of reducing the incidence of stroke in AF patients and the limiting unnecessary use of thromboprophylaxis. The thromboembolic risks posed by AF with valvular heart disease are an important subgroup that contributes to a significant proportion of stroke in AF patients globally. We review the evolution of stroke risk stratification and summarize the guidelines for stroke prevention in non-valvular AF as well as AF with valvular heart disease, and the most recent recommendations on stroke prevention in AF patients. Abbreviations: AF: Atrial Fibrillation; ACS: Acute Coronary Syndrome; CAD: Coronary Artery Disease; CCF: Congestive Cardiac Failure; DM: Diabetes Mellitus; EHRA: Evaluated Heartvalves, Rheumatic or Artificial; ICH: Intracranial Hemorrhage; NOACs: Novel Oral Anticoagulants; OAC: Oral Anticoagulants; PAD: Peripheral Arterial Disease ; TIA: Transient Ischemic Attack; VHD: Valvular Heart Disease.

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“…Thus, CAD and arterial hypertension [ 76 , 77 , 78 , 79 , 80 , 81 ], CAD and atrial fibrillation [ 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ] and CAD and vascular cognitive disorders [ 92 , 93 , 94 , 95 ] are common comorbid conditions with overlap syndrome. Therefore, the study of LTL seems important not only in isolated CAD and AMI but also in these syndromes of mutual aggravation.…”

Section: Discussionmentioning

confidence: 99%

Leukocyte Telomere Length as a Molecular Biomarker of Coronary Heart Disease

Zimnitskaya

Петрова

Lareva

et al. 2022

Genes

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Background. This work is a review of preclinical and clinical studies of the role of telomeres and telomerase in the development and progression of coronary heart disease (CHD). Materials and methods. A search for full-text publications (articles, reviews, meta-analyses, Cochrane reviews, and clinical cases) in English and Russian was carried out in the databases PubMed, Oxford University Press, Scopus, Web of Science, Springer, and E-library electronic library using keywords and their combinations. The search depth is 11 years (2010–2021). Results. The review suggests that the relative leukocyte telomere length (LTL) is associated with the development of socially significant and widespread cardiovascular diseases such as CHD and essential hypertension. At the same time, the interests of researchers are mainly focused on the study of the relative LTL in CHD. Conclusions. Despite the scientific and clinical significance of the analyzed studies of the relative length of human LTL as a biological marker of cardiovascular diseases, their implementation in real clinical practice is difficult due to differences in the design and methodology of the analyzed studies, as well as differences in the samples by gender, age, race, and ethnicity. The authors believe that clinical studies of the role of the relative length of leukocyte telomeres in adult patients with coronary heart disease are the most promising and require large multicenter studies with a unified design and methodology.

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CAD Is an Independent Risk Factor for Stroke Among Patients With Atrial Fibrillation

Cited by 20 publications

References 3 publications

Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease

Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease

Stroke risk stratification in atrial fibrillation: a review of common risk factors

Leukocyte Telomere Length as a Molecular Biomarker of Coronary Heart Disease

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