Cactus flower extracts may prove beneficial in benign prostatic hyperplasia due to inhibition of 5α reductase activity, aromatase activity and lipid peroxidation

Jonas, Adi; Rosenblat, Gennady; Krapf, Daniel; Bitterman, William; Néeman, I.

doi:10.1007/s002400050055

Cited by 22 publications

(5 citation statements)

References 15 publications

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“…Besides a mechanism involving androgenic effects, numerous previous studies have shown that lipid peroxides are involved in the regulation of cellar proliferation and cytotoxicity. Dietary EPA and DHA are sources of lipid peroxides, and their cytotoxicity is concentration dependent (37) and may influence BPH through nonhormonal mechanisms (38). The results of an animal study suggest that nϪ3 polyunsaturated fatty acids suppress sympathetic nervous system activity (39), which does not support a positive effect on the dynamic component of BPH.…”

Section: Discussionmentioning

confidence: 97%

Intakes of energy and macronutrients and the risk of benign prostatic hyperplasia

Suzuki

Platz

Kawachi

et al. 2002

The American Journal of Clinical Nutrition

104

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Section: Discussionmentioning

confidence: 97%

Intakes of energy and macronutrients and the risk of benign prostatic hyperplasia

Suzuki

Platz

Kawachi

et al. 2002

The American Journal of Clinical Nutrition

104

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“…Herbal extracts, such as black tea and mango ex tracts, have been shown to reduce oxidative stress in testosterone (T)-treated rats and mice, respectively [15,16], and an extract from the cactus flower displayed antioxidant effects and inhibited the 5αreductase acti vity in rat prostate homogenates [17]. In addition, Prunus africana bark and saw palmetto extracts, which are commonly used to treat BPH, have shown antioxidant effects when given orally [18,19].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant effects of D-004, a lipid extract from the Roystonea regia fruit, on the plasma of healthy men

López¹,

Molina²,

Illnait³

et al. 2009

Asian J Androl

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The aim of this study was to conduct a randomized, double-blind and placebo-controlled study to investigate the effects of D-004, a lipid extract of the Roystonea regia fruit that prevents testosterone- and phenylepinephrine-induced prostate hyperplasia in rodents, on plasma oxidative markers in healthy men. We enrolled male volunteers (20-55 years) in good health and without lower urinary tract symptoms. Thirty-four eligible participants were randomized to placebo or D-004 (320 mg) capsules administered daily for 6 weeks. An interim check-up and a final visit were conducted after 3 and 6 weeks of therapy, respectively. Physical examinations were performed at each visit, and laboratory tests were performed at baseline and at treatment completion. Oxidative variables included plasma malondialdehyde (MDA), total hydroxyperoxides (TOH), sulphydryl (SH) groups and total antioxidant status (TAS). We assessed treatment compliance and addressed adverse experiences (AEs) at weeks 3 and 6. At week 6, with D-004, the mean reductions of plasma MDA (26.7%), TOH (18.8%) and SH groups (31.6%), and the mean increase of TAS (35.3%) were significantly different from those of placebo (P<0.001 for plasma TAS, P<0.0001 for all other comparisons). D-004 did not differ from the placebo in safety indicators. There were two withdrawals (both in the D-004 group), with one due to dyspepsia (the only AE during the trial). In conclusion, D-004 displayed antioxidant effects on plasma oxidative markers in healthy men, which was consistent with findings from laboratory experimental studies.

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“…Cactus flower (Opuntia) is postulated to have simultaneous 5-α-reductase and aromatase inhibitory activity as well as antioxidant activity [40]. It is widely used in the treatment of BPH in Israel.…”

Section: Cactus Flowermentioning

confidence: 99%

Update on the Use of Phytotherapy for Voiding Symptoms

Fariello

Moldwin

2010

Curr Bladder Dysfunct Rep

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Phytotherapy-the use of plant extracts as medicine or health-promoting agents-is increasing in popularity. The most recent available survey, conducted in 2007 by the Centers for Disease Control and Prevention's National Center for Health Statistics, showed that adults in the United States spent 33.9 billion dollars out of pocket annually on complementary and alternative medical therapies. Of that total, 14.8 billion dollars (44%) was spent on herbal or phytotherapy products. These remedies are commonly used to treat urologic disorders such as benign prostatic hyperplasia, lower urinary tract symptoms, chronic prostatitis/chronic pelvic pain syndrome, overactive bladder, and interstitial cystitis/painful bladder syndrome. Although these agents show some promise for symptom relief, their use remains controversial due to the lack of established mechanisms of action, efficacy, and safety. Clinical trials are often flawed, as most studies of small scale and short duration are; they are not blinded or controlled, and most have no placebo group.

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Cactus flower extracts may prove beneficial in benign prostatic hyperplasia due to inhibition of 5α reductase activity, aromatase activity and lipid peroxidation

Cited by 22 publications

References 15 publications

Intakes of energy and macronutrients and the risk of benign prostatic hyperplasia

Intakes of energy and macronutrients and the risk of benign prostatic hyperplasia

Antioxidant effects of D-004, a lipid extract from the Roystonea regia fruit, on the plasma of healthy men

Update on the Use of Phytotherapy for Voiding Symptoms

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