Cacti for production of metabolites: current state and perspectives

Santos-Díaz, María del Socorro; Camarena-Rangel, Nancy Gabriela

doi:10.1007/s00253-019-10125-5

Cited by 17 publications

(7 citation statements)

References 84 publications

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“…The phytochemical approach of R. baccifera performed with crude ethanolic extract indicated alkaloids, flavonoids, phenylpropanoids, terpenes and triterpenes. According to the literature, the alkaloids are the most found secondary metabolites in Cactaceae (Cassels, 2019;Santos-Díaz & Camarena-Rangel, 2019), ratifying the findings in our study. It is noted that not all species of these plants have all compounds as found in this study.…”

Section: Phytochemical Profilesupporting

confidence: 91%

Phytochemical profile, toxicological evaluation of Rhipsalis baccifera (Sol.) Stearn (Cactaceae) extract and their antitumor activity in Ehrlich carcinoma-bearing mice

Cavalcantea¹,

Neto²,

Figueiredo³

et al. 2021

NRFHH

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Rhipsalis baccifera (Sol.) Stearn is a typical cactus from tropical regions with wide geographic distribution, and its therapeutic potential is not yet fully understood, such as antitumoral property. Thus, this study evaluated the cytotoxic ethanolic extract of R. baccifera (EERB) and its antitumor activity against Erlich's tumor in mice. The EERB was obtained, and its phytochemical profile was filed by thin-layer chromatography. The toxicity was evaluated in vitro and in vivo using the microcrustacean Artemia salina Leach and mice. The lethal dose was determined after implantation of a tumor cell suspension, with subsequent treatment with EERB (200 mg/kg and 100 mg/kg) 48h after implantation. These values represent the tenth part of the DL50 and CL50, respectively. The presence of phenols, tannins and triterpenes were demonstrated in the phytochemical results. Toxicity was dose-dependent, and the tumor inhibition was 84.1% and 75.8% at doses of 200 mg/kg and 100 mg/kg, respectively. We can highlight that the growth of Erlich's carcinoma suffered inhibitory effects against the EERB. EERB was found to have low acute toxicity and a high potential for use in antitumor therapy. Thus, new studies involving pre-clinical and clinical analyses of the extract are essential to determine the safe dose.

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Section: Phytochemical Profilesupporting

confidence: 91%

Phytochemical profile, toxicological evaluation of Rhipsalis baccifera (Sol.) Stearn (Cactaceae) extract and their antitumor activity in Ehrlich carcinoma-bearing mice

Cavalcantea¹,

Neto²,

Figueiredo³

et al. 2021

NRFHH

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“…30 The presence of terpenes has been identified in other species of the Cactaceae family such as Echinopsis, Hertrichocereus, Isolatocereus, Machaerocereus Opuntias, Pereskia , and Trichocereus species, both in the skin, stem, cladodes, seeds, leaves and roots. 31…”

Section: Resultsmentioning

confidence: 99%

Garambullo (Myrtillocactus geometrizans): effect of in vitro gastrointestinal digestion on the bioaccessibility and antioxidant capacity of phytochemicals

et al. 2022

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“…The above report was described in one of the first reviews of Cactaceae chemistry [37]. Although the alkaloids and polyphenols have already been described in several species, their biological activities have been studied extensively, and a recent report has been published [12]. However, the systematic revision of the chemistry of sterols and triterpenes from cacti and their biological activities is pending.…”

Section: Chemistry Of Cactaceaementioning

confidence: 98%

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae

2020

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The Cactaceae family is an important source of triterpenes and sterols. The wide uses of those plants include food, gathering, medicinal, and live fences. Several studies have led to the isolation and characterization of many bioactive compounds. This review is focused on the chemistry and biological properties of sterols and triterpenes isolated mainly from some species with columnar and arborescent growth forms of Mexican Cactaceae. Regarding the biological properties of those compounds, apart from a few cases, their molecular mechanisms displayed are not still fully understand. To contribute to the above, computational chemistry tools have given a boost to traditional methods used in natural products research, allowing a more comprehensive exploration of chemistry and biological activities of isolated compounds and extracts. From this information an in silico bioprospection was carried out. The results suggest that sterols and triterpenoids present in Cactaceae have interesting substitution patterns that allow them to interact with some bio targets related to inflammation, metabolic diseases, and neurodegenerative processes. Thus, they should be considered as attractive leads for the development of drugs for the management of chronic degenerative diseases.

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Cacti for production of metabolites: current state and perspectives

Cited by 17 publications

References 84 publications

Phytochemical profile, toxicological evaluation of <i>Rhipsalis baccifera</i> (Sol.) Stearn (Cactaceae) extract and their antitumor activity in Ehrlich carcinoma-bearing mice

Phytochemical profile, toxicological evaluation of <i>Rhipsalis baccifera</i> (Sol.) Stearn (Cactaceae) extract and their antitumor activity in Ehrlich carcinoma-bearing mice

Garambullo (Myrtillocactus geometrizans): effect of in vitro gastrointestinal digestion on the bioaccessibility and antioxidant capacity of phytochemicals

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae

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