CACNA1C (rs1006737) is associated with schizophrenia

Nyegaard, Mette; Demontis, Ditte; Foldager, Leslie; Hedemand, Anne; Flint, T; Sørensen, Karina Meden; Andersen, Paal Skytt; Nordentoft, Merete; Werge, Thomas; Pedersen, Carsten Bøcker; Hougaard, David M.; Mortensen, Preben Bo; Mors, Ole; Børglum, Anders D.

doi:10.1038/mp.2009.69

Cited by 170 publications

(127 citation statements)

References 10 publications

Supporting

Mentioning

114

Contrasting

Unclassified

Order By: Relevance

“…Thus, after quality control, six SNPs with nice cluster plots were left for analyses. Genotyping was performed using the Sequenom MassARRAY platform as described previously (Nyegaard et al, 2010;Buttenschøn et al, 2011). In order to evaluate the quality of our genotypes, 15% of the individuals included in this study were genotyped twice.…”

Section: Genotypingmentioning

confidence: 99%

Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level

Elfving

Buttenschøn

Foldager

et al. 2012

Journal of Psychiatric Research

View full text Add to dashboard Cite

Section: Genotypingmentioning

confidence: 99%

Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level

Elfving

Buttenschøn

Foldager

et al. 2012

Journal of Psychiatric Research

View full text Add to dashboard Cite

“…The non-coding CACNA1C rs1006737 risk A allele has been associated with risk for bipolar disorder (BD) [25,69], major depression [29], schizophrenia [29,53,58,67] and schizotypal personality disorder [64]. Studies that try to understand gene effects in brain function [50] indicate that the same allele is associated with decreased gene expression [65], increased anxious/depressive/paranoid personality traits and psychopathology [21,63] and increased hippocampal/amygdala activity [7,38,74] with reduced corticolimbic/frontotemporal functional connectivity during emotional face-processing [73].…”

Section: Introductionmentioning

confidence: 99%

The effects of theCACNA1Crs1006737 A/G on affective startle modulation in healthy males

et al. 2015

View full text Add to dashboard Cite

Healthy homozygous males for the risk A allele appear to have marked contextual sensitivity, affective reactivity akin to anxiety and depression and inefficient emotional appraisal. Our findings provide phenotypic detail of the CACNA1C AA genotype in non-symptomatic individuals, which suggest primary effects in emotional circuitry, consistent with previously documented alterations in hippocampal/amygdala processing.

show abstract

“…Recent genome-wide association studies (GWAS) suggest that variations in L-type calcium channel genes are part of the genetic architecture that confers susceptibility to schizophrenia [1,2] and bipolar disorder [3][4][5]. A growing body of evidence suggests that variation within the CACNA1C gene may confer susceptibility to psychosis.…”

Section: Introductionmentioning

confidence: 99%

CACNA1C risk variant is associated with increased amygdala volume

Lancaster

Foley

Tansey

et al. 2015

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Genome-wide association studies suggest that genetic variation within L-type calcium channel subunits confer risk to psychosis. The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology. Amongst others, it has been implicated in alterations in amygdala structure and function. In the present study, we show that the risk allele (A) is associated with increased amygdala volume in healthy individuals (n = 258). This observation reinforces a hypothesis that genetic variation may confer risk to psychosis via alterations in limbic structures. Further study of CACNA1C using intermediate phenotypes for psychosis will determine the mechanisms by which variation in this gene confers risk.

show abstract

CACNA1C (rs1006737) is associated with schizophrenia

Cited by 170 publications

References 10 publications

Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level

Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level

The effects of theCACNA1Crs1006737 A/G on affective startle modulation in healthy males

CACNA1C risk variant is associated with increased amygdala volume

Contact Info

Product

Resources

About