Cacao extract enriched in polyphenols prevents insulin-resistance and dyslipemia in a rat model

Ríos, José Ignacio Valenzuela; Villagarcía, Hernán Gonzalo; María, Cristina; Arbeláez, Luisa González; María, L Massa; Schinella, Guillermo Raúl; Francini, Flavio

doi:10.1055/s-0037-1608483

Cited by 1 publication

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“…weight (bw)] from cacao did not modify GK activity in an insulin resistance and dyslipidemia rat model. 10 However, the polyphenol extract from jambul fruits (20 mg/kg of bw) upregulated hepatic GK in Swiss albino mice. 11 Moreover, the pure compounds present in mulberry (25−100 μM), 1deoxynojrimycin, resveratrol, oxyresveratrol, cyanidin-3-glucoside, and cyanidin-3-rutinoside, activated GK in HepG2 cells.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Contrasting results have been reported for polyphenols from dietary sources to influence GK activity and expression in vitro and in vivo . A polyphenol-rich extract [250 mg/kg of body weight (bw)] from cacao did not modify GK activity in an insulin resistance and dyslipidemia rat model . However, the polyphenol extract from jambul fruits (20 mg/kg of bw) upregulated hepatic GK in Swiss albino mice .…”

Section: Introductionmentioning

confidence: 99%

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Activating Effects of Phenolics from Apache Red Zea mays L. on Free Fatty Acid Receptor 1 and Glucokinase Evaluated with a Dual Culture System with Epithelial, Pancreatic, and Liver Cells

Luna‐Vital

Chatham

Juvik

et al. 2019

J. Agric. Food Chem.

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The aim was to characterize a phenolic-rich water extract from the pericarp of an improved genotype of Apache red maize (RPE) and evaluate its ability to activate the type 2 diabetes markers free fatty acid receptor 1 (GPR40) and glucokinase (GK) in vitro. The extract contained mainly phenolic acids, anthocyanins, and other flavonoids. RPE inhibited αamylase (IC 50 = 88.3 μg/mL), α-glucosidase (IC 50 = 169.3 μg/mL), and reduced glucose transport in a Caco-2 cell monolayer (up to 25%). Furthermore, RPE activated GPR40 (EC 50 = 77.7 μg/mL) in pancreatic INS-1E cells and GK (EC 50 = 43.4 μg/ mL) in liver HepG2 cells, potentially through allosteric modulation. RPE activated GPR40-related insulin secretory pathway and activated the glucose metabolism regulator AMPK (up to 78%). Our results support the hypothesis that foods with a high concentration of anthocyanins and phenolic acids, such as in the selected variety of maize used, could ameliorate obesity and type 2 diabetes comorbidities.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%