CaBPs and other immunohistochemical markers of the human vomeronasal system: A comparison with other mammals

Johnson, Edward W.

doi:10.1002/(sici)1097-0029(19980615)41:6<530::aid-jemt8>3.0.co;2-q

Cited by 16 publications

(5 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For decades, such conflicting information has frustrated authors, leading some to question the functionality of the adult human VNO (e.g., Johnson, 1998; Wysocki and Preti, 2000), and even to doubts regarding the homology of the human VNO to that of other mammals (see Smith et al, 1998; Smith and Bhatnagar, 2000). Prenatal development of human VNO provides the answer to the question of homology.…”

Section: The Human Vnomentioning

confidence: 99%

Reappraisal of the vomeronasal system of catarrhine primates: Ontogeny, morphology, functionality, and persisting questions

Smith

Siegel²,

Bhatnagar³

2001

Anat. Rec.

View full text Add to dashboard Cite

Section: The Human Vnomentioning

confidence: 99%

Reappraisal of the vomeronasal system of catarrhine primates: Ontogeny, morphology, functionality, and persisting questions

Smith

Siegel²,

Bhatnagar³

2001

Anat. Rec.

View full text Add to dashboard Cite

“…Furthermore, olfactory marker protein (OMP), which is a characteristic feature of mature chemosensory neurons, has not been found in the adult human VNO [9]. A few bipolar neurons do stain for some neural markers, but they share these immunohistochemical characteristics with neuroendocrine cells scattered through human nonsensory, respiratory epithelium [10]. Convincing evidence of a central projection from the human VNO is also lacking in adults, although clearly present in the fetus.…”

Section: Behavioural and Physiological Responses Mediated By The Vomementioning

confidence: 99%

The vomeronasal system

Brennan¹

2001

CMLS, Cell. Mol. Life Sci.

115

View full text Add to dashboard Cite

In addition to the main olfactory system, many vertebrates possess a vomeronasal system that conveys more specialized chemosensory information. Unlike the airborne, volatile stimuli detected by the main olfactory system, vomeronasal stimuli are typically proteins of the lipocalin family which bind small, volatile ligands. Despite the smaller number of vomeronasal receptor types, the projection patterns of the vomeronasal receptor neurons to multiple glomeruli in the accessory olfactory bulb appear to be more complicated than those of the main olfactory system. The vomeronasal system has a direct subneocortical projection to hypothalamic areas that mediates specific behavioural and hormonal responses to pheromonal stimuli. However, the integration and transmission of this information can be modulated by learning mechanisms. The aim of this article is to outline some of the functions of the vomeronasal system, and in particular to comment on recent advances in our understanding of how vomeronasal information is coded and processed.

show abstract

“…Several authors reported that the human fetal VE has immunoreactivity for neuron‐specific molecules, such as calbindin D28k (Johnson et al, ; Johnson, ), neuron‐specific enolase (Boehm and Gasser, ), and PGP (Kjaer and Hansen, ; Takami et al, ). Using a silver impregnation technique, Ortmann () calculated 212 VRCs per VNO in two 13‐week‐old specimens from human fetuses and 72 VRCs per VNO in 15‐week‐old specimens.…”

Section: Discussionmentioning

confidence: 99%

Morphological Analysis for Neuron‐Like Cells in the Vomeronasal Organ of Human Fetuses at the Middle of Gestation

Takami

Yukimatsu

Matsumura

et al. 2015

The Anatomical Record

View full text Add to dashboard Cite

The vomeronasal organ (VNO) of 5-month-old fetuses was examined immunohistochemically by the use of an antiserum to protein gene product 9.5 (PGP). The purpose was to identify if the human fetal VNO is lined by neuroepithelium. The PGP antiserum labeled abundant cells within the vomeronasal epithelium (VE), nerve fiber bundles in its lamina propria, and cells associated with these bundles. PGPimmunoreactive (ir) vomeronasal epithelial cells were classified into three subtypes. Type I cells, about 44% of the total cells observed, did not have any processes and tended to be located in the basal layer of the VE. Type II cells, about 37%, had a single apical process that projected toward the lumen, ending at the epithelial surface. Type III cells sent a prominent process mainly toward the basement membrane, and occupied about 19% of the total cells observed. In the lamina propria, a considerable number of PGP-ir cells was observed. Some of them were present in nerve fiber bundles and contained processes parallel to the bundles. In addition, PGP-ir nerve fiber bundles and cells associated with them were even present in the portion of the nasal septal mucosa that was very close to the brain. The present results strongly suggested that the VE in human fetuses at mid-gestation is a neuroepithelium and that the VE may produce migrating cells toward the brain. Anat Rec, 299:88-97, 2016. V C 2015 Wiley Periodicals, Inc.

show abstract

CaBPs and other immunohistochemical markers of the human vomeronasal system: A comparison with other mammals

Cited by 16 publications

References 119 publications

Reappraisal of the vomeronasal system of catarrhine primates: Ontogeny, morphology, functionality, and persisting questions

Reappraisal of the vomeronasal system of catarrhine primates: Ontogeny, morphology, functionality, and persisting questions

The vomeronasal system

Morphological Analysis for Neuron‐Like Cells in the Vomeronasal Organ of Human Fetuses at the Middle of Gestation

Contact Info

Product

Resources

About