CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells
David Oestreicher,
Shashank Chepurwar,
Kathrin Kusch
et al.
Abstract:To encode continuous sound stimuli, the inner hair cell (IHC) ribbon synapses utilize calcium-binding proteins (CaBPs), which reduce the inactivation of their CaV1.3 calcium channels. Mutations in theCABP2gene underlie non-syndromic autosomal recessive hearing loss DFNB93. Besides CaBP2, the structurally related CaBP1 is highly abundant in the IHCs. Here, we investigated how the two CaBPs cooperatively regulate IHC synaptic function. InCabp1/2double-knockout mice, we find strongly enhanced CaV1.3 inactivation,… Show more
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