Cabozantinib prevents AGEs-induced degradation of type 2 collagen and aggrecan in human chondrocytes
Yang Dong,
Lianfang Lin,
Yuan Ji
et al.
Abstract:Osteoarthritis (OA) is a joint degenerative disease commonly observed in the old population, lacks effective therapeutic methods, and markedly impacts the normal lives of patients. Degradation of extracellular matrix (ECM) is reported to participate in OA development, which is a potential target for treating OA. Cabozantinib is an inhibitor of tyrosine kinases and is recently claimed with suppressive properties against inflammation. Herein, the protective function of Cabozantinib on advanced glycation end prod… Show more
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