Cabergoline (Dostinex) Effect on Weight Ovarian Function

Al-Ameri, Rawa Jaafar Kadhim

doi:10.4172/2327-4972.1000217

Cited by 2 publications

(2 citation statements)

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“…This finding aligns with existing research indicating the effectiveness of metformin in reducing weight in patients with PCOS [21,22]. Additionally, some studies have suggested that cabergoline can reduce body weight in women with PCOS [23].…”

Section: Discussionsupporting

confidence: 90%

Effects of combined metformin and cabergoline versus metformin alone on ovarian and hormonal activities in Iraqi patients with PCOS and hyperprolactinemia: a randomized clinical trial

Fawzi,

Hamad,

Kadhim

et al. 2023

JMedLife

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Polycystic ovary syndrome (PCOS) is one of the most prevalent metabolic diseases during female reproductive life, often associated with insulin resistance and hyperprolactinemia. The efficacy of metformin and cabergoline for managing PCOS remains debated in the literature. This three-arm interventional study in Iraq assessed the effects of these drugs on body mass index (BMI), hormonal balance, and uterine artery blood flow in 75 women with PCOS and hyperprolactinemia. Participants were randomized into three groups: metformin (500 mg twice daily), cabergoline (0.5 mg weekly), and a combination of both, with 25 patients in each group. Baseline and 90-day follow-up characteristics included BMI, serum hormonal levels, and ultrasound features. Metformin resulted in significant weight reduction (p=0.038); however, the addition of cabergoline caused a more significant reduction in body mass index (p=0.001). The combined treatment significantly lowered testosterone levels (p=0.008). In addition, this combination significantly reduced the level of LH (p=0.043) and increased the level of FSH (p=0.047). The results suggest that metformin and cabergoline when used together, act synergistically and safely to reduce BMI, testosterone, and LH levels while increasing FSH levels. Furthermore, this combination improved endometrial blood flow and ovulation in women with PCOS.

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Section: Discussionsupporting

confidence: 90%

Effects of combined metformin and cabergoline versus metformin alone on ovarian and hormonal activities in Iraqi patients with PCOS and hyperprolactinemia: a randomized clinical trial

Fawzi,

Hamad,

Kadhim

et al. 2023

JMedLife

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“…В іншому багатоцентровому дослідженні безпечності карбеголіну та бромкриптину відзначається досить висока частота появи побічних ефектів у жінок, які отримували карбеголін (16% випадків) та бромкриптин (26%) [29]. З огляду на ймовірність таких серйозних побічних реакцій, як тромбоемболії, геміанопсія, парез лицевого нерва, призначення інгібіторів пролактину здебільшого обґрунтовується складними клінічними ситуаціями, що потребують швидкого припинення грудного вигодовування [3,9, 18]. Тому на сьогодні актуальний пошук альтернативних методів фармакотерапії для покращення ефективності фізіологічного припинення лактації.На особливий інтерес заслуговують препарати рослинного походження, які через комплекс біологічно активних речовин в їх складі здатні впливати на різні процеси в організмі людини.…”

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Experience of using plant complexes in physiological completion of lactation

Косей

Zanko²,

Vasylchenko³

et al. 2021

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Ending breastfeeding is often quite a challenge for women, justifying the need for qualified medical counseling and accompaniment by a doctor. Quite frequently during weaning the baby, women complain about pain, discomfort and swelling of the breasts, which affects their overall physical and psychological well-being. However, due to possible rather serious side effects, medical support for stopping lactation is mostly recommended for women with clinical indications.Research aim: to determine the effectiveness of the proposed method with Normomens for physiological completion of lactation.Materials and methods. The study involved 65 women with an average duration of lactation 9 ± 1.23 months. Patients were divided into two groups: group 1 included 34 women who received Normomens according to the scheme to stop lactation; group 2 included 31 patients who did not receive any medication. Patients were gynecological examined and counseled by oncologist. Patients' diaries included questions about the duration of lactation, presence and severity of mastalgia according to the Visual Analogue Scale, necessity of analgesics, frequency of breast pumping per day, features of psycho-emotional state according to the Hospital Anxiety and Depression Scale. Prolactin levels were also determined at the screening visit and on 25th day after weaning.Results. On the background of Normomens use the process of lactation completion was significantly easier, its completion came mostly on the 3–4 day after drug use, patients almost never complained of pain and discomfort in mammary glands, they less frequently breast pumped and had a more stable psycho-emotional state compared to the control group. Рrolactin level with usage of Normomens had a quick decrease compared to the control group.Conclusion. Normomens using for support the physiological finishing of lactation lead to acceleration of involutive processes in mammary glands, reduces pain severity and prevented psycho-emotional disorders in women.

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Cabergoline (Dostinex) Effect on Weight Ovarian Function

Cited by 2 publications

References 1 publication

Effects of combined metformin and cabergoline versus metformin alone on ovarian and hormonal activities in Iraqi patients with PCOS and hyperprolactinemia: a randomized clinical trial

Effects of combined metformin and cabergoline versus metformin alone on ovarian and hormonal activities in Iraqi patients with PCOS and hyperprolactinemia: a randomized clinical trial

Experience of using plant complexes in physiological completion of lactation

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