CA724 predicts overall survival in locally advanced gastric cancer patients with neoadjuvant chemotherapy

Abstract

Background: Serum tumor markers are of great importance in diagnosis, prognostic predicting and recurrence monitoring in gastrointestinal malignancy, including AFU, AFP, CEA, CA199, CA125 and CA724. However, their significances in gastric cancer (GC) patients with neoadjuvant therapy (NCT) are still uncertain. The aim of this study is to evaluate the predictive value of these six tumor markers in locally advanced GC patients with NCT and curative surgery. Methods: 290 locally advanced GC patients with NCT and D2 radical gastrectomy were retrospectively analyzed. Their tumor markers before (pre-) and after (post-) NCT and pathological characters were exacted from the database in our hospital. The optimal cutoff values of six tumor markers were calculated by ROC and Youden index. Their predictive significances were analyzed and survival curves on overall survival (OS) were obtained by Kaplan-Meier method. Associations between categorical variables were explored by Chi-square test or Fisher's exact method. Multivariate analyses were performed by Cox regression model. Results: Not only the pre- and post- CA199, CA125 and CA724 could predict the OS respectively, but also the changes (diff-) between post- and pre- groups were related to the prognosis (P < 0.05). In multivariable analysis, only pre- (P = 0.016) and post-CA724 (P = 0.033) remained significant, and the significance of diff-CA724 was on borderline (P = 0.085). Besides, pre- and post-CA199, CA125 and CA724 were associated with the metastasis of lymph node (N- vs N+) and pathological stage (Ⅰ-Ⅱ vs Ⅲ) (P < 0.05). Post-CA724 was related to the invasion of vascular or lymphatic vessels (P = 0.019), and pre-CA724 was nearly remarkable (P = 0.082). However, AFU, AFP and CEA showed no association with survival (P > 0.05). Conclusions: CA724 is an independent factor to prognosis, and could be used to predict the ypN and ypTNM stage in locally advanced GC patients undergone NCT and curative resection.

Development of a Clinical Nomogram for Prediction of Response to Neoadjuvant Chemotherapy in Patients with Advanced Gastric Cancer

“…Other studies had shown that, CA724 was an independent factor for e cacy of NAC in gastric cancer [30]. Our study reached the same conclusion that the higher the level of CA724, the worse the response to NAC.…”

CA724 Predicts Tumor Regression Grade in Locally Advanced Gastric Cancer Patients with Neoadjuvant Chemotherapy

“…The difference was that they used RECIST criteria rather than TRG. In our another article [20], we found that CA724 before treatment and CA724 after treatment were both independent predictive factors for overall survival. However, in that article, TRG was not mentioned.…”

Study on the Differential Value of Tumor Marker CA724 on Primary Gastric Cancer

“…Tumor biomarker CA724 trended to be considered as an independent prognostic factor [ 19 ]. Tong et al found that CA724 predicted overall survival in locally advanced gastric cancer patients with neoadjuvant chemotherapy [ 20 ]. In this study, there was no significant difference between the levels of tumor marker CA724 in control group 1 and control group 2 ( p > 0.05), while the level of tumor marker CA724 in the observation group was higher than that in both control group 1 and control group 2 ( p < 0.05).…”