Ca2+-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells

Jankowska, Anna; Sharma, Rameshwar K.; Duda, Teresa

doi:10.3389/fnmol.2014.00034

Cited by 8 publications

(8 citation statements)

References 51 publications

(91 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have shown that calcium ions were a decisive factor that affected sperm cell functions, including forward movement, activation, capacitation and acrosome reaction (Jankowska, Sharma, & Duda, ; Marin‐Briggiler et al, ). Accordingly, Ca 2+ ‐permeable channels and Ca 2+ transporters are found in sperm cells.…”

Section: Discussionmentioning

confidence: 99%

Diltiazem aggravates testicular function impairment induced by cyclosporine A or tacrolimus in unilateral nephrectomised rats

et al. 2019

View full text Add to dashboard Cite

The aim of this study was to elucidate the reproductive toxicity of the coadministration of diltiazem and cyclosporine A or tacrolimus. Testicular development, semen quality, sex hormones and testicular tissues were assessed in unilateral nephrectomised (UN) rats, including the control group, UN group, UN+CsA group, UN+FK506 group, UN+Rapa group, UN+CsA+Dil group and UN+FK506+Dil group. The testicular coefficient, the sperm number and the sperm motility were lower in the treatment groups (except UN+FK506) than in the control and UN groups (all p < 0.05). The lowest sperm number and motility were identified in the UN+CsA+Dil group, followed by the UN+CsA group. The proportion of abnormal sperm was higher in the UN+CsA and UN+CsA+Dil groups than in the control and UN groups, respectively (p < 0.05).The plasma concentrations of sex hormones were changed in the treatment groups. Dil can increase the blood concentrations of CsA and FK506 (◇p < 0.05, ◆p < 0.05). Therapeutic doses of these agents induced morphological changes in the testicular tissue and ultrastructural changes in the testosterone, mesenchymal cells and supporting cells. Our present study suggests that Dil can increase the testicular toxicity of CNIs (calcineurin inhibitors, including CsA and FK506) by enhancing the plasma concentrations of CNIs. K E Y W O R D S calcium channel blockers, immunosuppressive agents, renal transplantation, reproductive function How to cite this article: Lin Y, Zhang J, Lei W, et al. Diltiazem aggravates testicular function impairment induced by cyclosporine A or tacrolimus in unilateral nephrectomised rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Diltiazem aggravates testicular function impairment induced by cyclosporine A or tacrolimus in unilateral nephrectomised rats

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Biochemical studies demonstrate a ROS-GC1 transduction system modulated by GCAP1 and S100B in plasma membrane of bovine testes (Jankowska et al, 2007 , 2014 ). Immuno-stainings establish that these components co-localize in bovine and human sperm (Jankowska and Warchol, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

“…Immuno-stainings establish that these components co-localize in bovine and human sperm (Jankowska and Warchol, 2010 ). A convergence of molecular genetics, biochemistry and immunohistochemistry disclose NCδ in male gonads (Jankowska et al, 2014 ). Thus, three sensors: GCAP1, S100B and NCδ, capture and transmit Ca 2+ signals to ROS-GC1 in this tissue.…”

Section: Introductionmentioning

confidence: 99%

Integrative Signaling Networks of Membrane Guanylate Cyclases: Biochemistry and Physiology

Sharma

Duda

Makino

2016

Front. Mol. Neurosci.

Self Cite

View full text Add to dashboard Cite

This monograph presents a historical perspective of cornerstone developments on the biochemistry and physiology of mammalian membrane guanylate cyclases (MGCs), highlighting contributions made by the authors and their collaborators. Upon resolution of early contentious studies, cyclic GMP emerged alongside cyclic AMP, as an important intracellular second messenger for hormonal signaling. However, the two signaling pathways differ in significant ways. In the cyclic AMP pathway, hormone binding to a G protein coupled receptor leads to stimulation or inhibition of an adenylate cyclase, whereas the cyclic GMP pathway dispenses with intermediaries; hormone binds to an MGC to affect its activity. Although the cyclic GMP pathway is direct, it is by no means simple. The modular design of the molecule incorporates regulation by ATP binding and phosphorylation. MGCs can form complexes with Ca2+-sensing subunits that either increase or decrease cyclic GMP synthesis, depending on subunit identity. In some systems, co-expression of two Ca2+ sensors, GCAP1 and S100B with ROS-GC1 confers bimodal signaling marked by increases in cyclic GMP synthesis when intracellular Ca2+ concentration rises or falls. Some MGCs monitor or are modulated by carbon dioxide via its conversion to bicarbonate. One MGC even functions as a thermosensor as well as a chemosensor; activity reaches a maximum with a mild drop in temperature. The complexity afforded by these multiple limbs of operation enables MGC networks to perform transductions traditionally reserved for G protein coupled receptors and Transient Receptor Potential (TRP) ion channels and to serve a diverse array of functions, including control over cardiac vasculature, smooth muscle relaxation, blood pressure regulation, cellular growth, sensory transductions, neural plasticity and memory.

show abstract

“…Originally discovered in retina where they play an integral role in phototransduction in the outer segments of photoreceptors (Margulis et al, 1993 ; Goraczniak et al, 1994 ; Duda et al, 1996 ), ROS-GCs are also present in the photoreceptor cell bodies (Rambotti et al, 1999 ), photoreceptor synaptic region (Duda et al, 2002 ; Venkataraman et al, 2003 ), Muller cells (Rambotti et al, 1999 ) and in ganglion cells (Krishnan et al, 2004 ). Outside the retina, they are expressed in pinealocytes (Venkataraman et al, 2000 ), in olfactory bulb neurons (Duda et al, 2001 ), in the anterior portion of gustatory epithelium (Duda and Sharma, 2004 ) and in sperm (Jankowska et al, 2014 ). Thus, ROS-GCs direct multimodal cellular signal transductions (Sharma et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Bicarbonate and Ca2+ Sensing Modulators Activate Photoreceptor ROS-GC1 Synergistically

Duda

Pertzev

Makino

et al. 2016

Front. Mol. Neurosci.

Self Cite

View full text Add to dashboard Cite

Photoreceptor ROS-GC1, a prototype subfamily member of the membrane guanylate cyclase family, is a central component of phototransduction. It is a single transmembrane-spanning protein, composed of modular blocks. In rods, guanylate cyclase activating proteins (GCAPs) 1 and 2 bind to its juxtamembrane domain (JMD) and the C-terminal extension, respectively, to accelerate cyclic GMP synthesis when Ca2+ levels are low. In cones, the additional expression of the Ca2+-dependent guanylate cyclase activating protein (CD-GCAP) S100B which binds to its C-terminal extension, supports acceleration of cyclic GMP synthesis at high Ca2+ levels. Independent of Ca2+, ROS-GC1 activity is also stimulated directly by bicarbonate binding to the core catalytic domain (CCD). Several enticing molecular features of this transduction system are revealed in the present study. In combination, bicarbonate and Ca2+-dependent modulators raised maximal ROS-GC activity to levels that exceeded the sum of their individual effects. The F514S mutation in ROS-GC1 that causes blindness in type 1 Leber’s congenital amaurosis (LCA) severely reduced basal ROS-GC1 activity. GCAP2 and S100B Ca2+ signaling modes remained functional, while the GCAP1-modulated mode was diminished. Bicarbonate nearly restored basal activity as well as GCAP2- and S100B-stimulated activities of the F514S mutant to normal levels but could not resurrect GCAP1 stimulation. We conclude that GCAP1 and GCAP2 forge distinct pathways through domain-specific modules of ROS-GC1 whereas the S100B and GCAP2 pathways may overlap. The synergistic interlinking of bicarbonate to GCAPs- and S100B-modulated pathways intensifies and tunes the dependence of cyclic GMP synthesis on intracellular Ca2+. Our study challenges the recently proposed GCAP1 and GCAP2 “overlapping” phototransduction model (Peshenko et al., 2015b).

show abstract

Ca2+-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells

Cited by 8 publications

References 51 publications

Diltiazem aggravates testicular function impairment induced by cyclosporine A or tacrolimus in unilateral nephrectomised rats

Diltiazem aggravates testicular function impairment induced by cyclosporine A or tacrolimus in unilateral nephrectomised rats

Integrative Signaling Networks of Membrane Guanylate Cyclases: Biochemistry and Physiology

Bicarbonate and Ca2+ Sensing Modulators Activate Photoreceptor ROS-GC1 Synergistically

Contact Info

Product

Resources

About