CA125‐producing adenocarcinoma of the seminal vesicle

Ohmori, Takaaki; Okada, K.; Tabei, Ryo; Sugiura, Kazuhiko; Nabeshima, Shinji; Ohoka, Hiroji; Okamoto, Masaki

doi:10.1111/j.1440-1827.1994.tb03372.x

Cited by 49 publications

(24 citation statements)

References 11 publications

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“…As reported previously, CA 125 was used as a serological marker to monitor treatment response [10]. In our patient, we observed a very good correlation between blood levels of CA 125 and clinical parameters, which was a useful tool in the therapeutic management of our patient.…”

Section: Discussionsupporting

confidence: 84%

Multiagent chemotherapy for metastatic adenocarcinoma of the seminal vesicle

et al. 2014

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Adenocarcinoma of the seminal vesicle is a rare condition, with fewer than 60 cases described in the literature. Most reports highlight the histopathological characteristics of the tumor; however, the role of chemotherapy, especially in the metastatic setting, is poorly described. In this paper, we describe a patient with metastatic disease, who sustained a response to modified FOLFOX6 as first-line therapy. This platinum-based combination therapy seems effective in this scenario and may provide an opportunity for extended survival and relief of symptoms.

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Section: Discussionsupporting

confidence: 84%

Multiagent chemotherapy for metastatic adenocarcinoma of the seminal vesicle

et al. 2014

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“…Less differentiated prostate carcinomas may be PSA (negative) and PAP (negative); there should not be a primary carcinoma focus in any other body region. [8][9][10][11][12][13][14][15] Normal serum levels of PSA and CEA prevent invasion of the prostate or colon carcinoma. However, increased serum CEA levels can also be observed in rare cases of seminal vesicle adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…CA-125 and cytokeratins 7 and 20 provide more valuable information for differentiating seminal vesicle adenocarcinoma from invasion of other organs by tumours (Table 2). [8][9][10][11][12][13][14][15] The prognosis of seminal vesicle adenocarcinoma is often poor due to delayed diagnosis. About 95% of the patients die in less than 3 years.…”

Section: Discussionmentioning

confidence: 99%

An unusual cause of hematospermia: Primary adenocarcinoma of the seminal vesicle

Eken

İzol

Aridogan

et al. 2012

CUAJ

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Adenocarcinoma of the seminal vesicles is one of the rare causes of hematospermia. Primary seminal vesicle adenocarcinoma is extremely rare and difficult to diagnose due to frequent invasion of adenocarcinomas of the surrounding organs, especially the prostate. In the present study, a case of a primary seminal vesicle adenocarcinoma will be discussed in the light of the current literature. IntroductionAdenocarcinoma of the seminal vesicles is one of the rare causes of hematospermia. Primary seminal vesicle adenocarcinoma is extremely rare and difficult to diagnose due to frequent invasion of adenocarcinomas of the surrounding organs, especially the prostate. Since it was first defined, 1 primary seminal vesicle adenocarcinoma has been reported in about 50 patients. In the present study, a case of a primary seminal vesicle adenocarcinoma will be discussed in the light of the current literature. Case reportA 57-year-old male was admitted with urinary retention and 3 episodes of hematospermia within the last 6 months. At another centre, transurethral resection of the bladder plus a prostatic urethral biopsy had been performed one month before due to retention; at that time, the pathologic examination revealed high-grade papillary urothelial carcinoma and mixed adenocarcinoma.During the visit at our centre, the rectal examination revealed a hard, palpable mass obstructing the lumen (grade 3/4). The prostate-specific antigen (PSA) level was 6.19 ng/ mL. The serum carcinoembryonic antigen (CEA) and CA19-9 levels were normal; CA125 was 71.5 U/mL (range: 0-20 U/ mL) and CA15-3 was 41.3 U/mL (range: 5-21 U/mL). During the cystoscopy, there were no tumoural lesions; an indentation was observed from the interior and a mass lesion filling the seminal vesicle region was noted on bimanual examination. Paraffin blocks of the earlier operation were re-examined. Tumour cells with a hobnail appearance and transparent cytoplasm showing papillary and glandular structures were observed. Immunohistochemical evaluation demonstrated that CEA and cytokeratin 7 were positive, and PSA and cytokeratin 20 were negative. A magnetic resonance image showed: a 10×15-cm malignant lesion of cystic-necrotic nature with irregular solid components at the base and a widespread hematoma invading the prostate and the seminal vesicle with a clear-cut interphase between the tumour and the bladder (Fig. 1). According to results, the patient was diagnosed with a seminal vesicle adenocarcinoma.A thin-walled cystic formation with an anterior surface of about 8 cm adhering to the bladder and sigmoid colon was noted on exploration. While the cystic formation was being excised from the surrounding tissues, due to perforation of the wall of the cystic formation, about 100 cc of serous fluid was drained. Solid components at the base of the cystic formation were excised as much as possible; however, some residual mass strongly adherent to the bladder base and rectum had to be left behind. Pathologic examination revealed a malignant tumour exhibiting papill...

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“…Some tumors have firm cut surfaces with irregular margins, [5,6] whereas others are predominantly cystic and are often filled with brownish fluid, pus or necrotic material. [7,8] In cases with cystic appearance, the cystic appearance of ASV can be suggestive of an old hemorrhage or abscess rather than cancer.…”

Section: Discussionmentioning

confidence: 99%

Primary adenocarcinoma of the seminal vesicles: a phantom tumor

Tyritzis¹,

Stamatiou²,

Zizi-Sermpetzoglou³

et al. 2012

Turkish Journal of Urology

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Primary adenocarcinoma of the seminal vesicles (ASV) is a very rare neoplasm with less than 50 histologically confirmed cases reported in the literature. The diagnosis is complex and is based on a combination of immunohistochemical, clinical and radiological findings. Biopsy is not always conclusive, and surgical resection is usually required to determine whether the tumor originated from the seminal vesicles. We present a case of primary ASV that was discovered upon investigation of inguinal lymphadenopathy. A history of recent hormonal manipulation for the treatment of infertility may be associated with the development or the progression of this rare tumor.

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CA125‐producing adenocarcinoma of the seminal vesicle

Cited by 49 publications

References 11 publications

Multiagent chemotherapy for metastatic adenocarcinoma of the seminal vesicle

Multiagent chemotherapy for metastatic adenocarcinoma of the seminal vesicle

An unusual cause of hematospermia: Primary adenocarcinoma of the seminal vesicle

Primary adenocarcinoma of the seminal vesicles: a phantom tumor

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