CA125 modified by PLT and NLR improves the predictive accuracy of adenomyosis-derived pelvic dense adhesion

Jiang, Cheng; Liu, Chao; Guo, Jing; Chen, Li; Luo, Ning; Qu, Xun; Yang, Wei; Ren, Qing; Cheng, Zhongping

doi:10.1097/md.0000000000006880

Cited by 9 publications

(3 citation statements)

References 20 publications

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“…A number of patients have high levels of serum CA125. CA125 modified by platelet count and neutrophil-lymphocyte ratio improves the predictive accuracy of adenomyosis-derived pelvic dense adhesion (3). Adenomyosis was considered to be a chronic immune inflammatory disease.…”

Section: Introductionmentioning

confidence: 99%

Correlation of LOX‑5 and COX‑2 expression with inflammatory pathology and clinical features of adenomyosis

Chen

Jiang

et al. 2018

Mol Med Report

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Adenomyosis is a common benign disease of women of childbearing age. The typical clinical features are prolonged menstruation, menorrhagia and ingravescent dysmenorrhea. In the present study, the severity of dysmenorrhea was assessed using the visual analogue scale system as follows: 0, No pain; 1-3, minimal pain; 4-6, moderate pain; and 7-10, severe pain. Menstrual blood loss was evaluated using the pictorial blood loss assessment chart (PBAC). Menorrhagia was defined as excessive menstrual blood loss >80 ml (PBAC >100) per period. Specimens of eutopic endometrium (EU) and ectopic endometrium (EC) were collected from 20 patients with adenomyosis to evaluate the association between lipoxygenase-5 (LOX-5) and cyclooxygenase 2 (COX-2) and inflammatory pathology and clinical features of adenomyosis. For that purpose, the expression levels of LOX-5, COX-2, interleukin (IL)-6 and IL-8 in the EU and EC of patients with adenomyosis were determined, and clinical data including dysmenorrhea and menstruation were analyzed. Differences in expression levels of LOX-5 and COX-2 were detected, and the correlations between LOX-5, COX-2, IL-6 and IL-8 in different groups were analyzed. In addition, the correlations between LOX-5, COX-2 and clinical features of adenomyosis were investigated. The present study demonstrated that LOX-5 and COX-2 are overexpressed in EU and EC, and they have positive correlations with IL-6 and IL-8, suggesting that adenomyosis lesions are present in inflammatory pathological conditions. The expression levels of LOX-5 and COX-2 exhibited a correlation with dysmenorrhea and menstruation.

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Section: Introductionmentioning

confidence: 99%

Correlation of LOX‑5 and COX‑2 expression with inflammatory pathology and clinical features of adenomyosis

Chen

Jiang

et al. 2018

Mol Med Report

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“…While NLR was found to be positively correlated with age in a study, no relationship between CA-125 and NLR and the stage of endometriosis was found [18]. Jiang et al [28], on the other hand, suggested that CA-125 combined with NLR and PLR may be a predictor of adenomyosis-related dense pelvic adhesions. Based on all these findings, it can be concluded that the relationships between NLR, PLR and CA-125 and the clinical symptoms of endometriosis are still unclear, and remain to be elucidated.…”

Section: "#$%And!?(!f:%40d#-0#4and!%02and#-!-and-and770+2!#2#%5707!+6!qrs!! T23andand23and24!d#-mentioning

confidence: 91%

The additional diagnostic value of NLR and PLR for CA-125 in the differential diagnosis of endometrioma and benign ovarian cysts in women of reproductive age: a retrospective case-control study

Kalem¹,

Bakırarar

Kalem

2020

The European Research Journal

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Objectives: Aim of this study is to investigate the diagnostic value of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) for cancer antigen-125 (CA-125) in a differential diagnosis of endometrioma from benign ovarian cysts. Methods: In this retrospective study, the medical data of a total of 213 patients aged < 40 years who underwent laparoscopic or laparotomic surgery for ovarian cysts between April 2015 and June 2018 were analyzed. The patients were divided into two groups, as those with endometriomas and those with other benign ovarian cysts, all which had been confirmed histopathologically. Data on age, body mass index (BMI), preoperative US findings, complete blood count analysis results, follicle-stimulating hormone (FSH) levels, and the presence of dysmenorrhea, dyspareunia and chronic pelvic pain were recorded. Results: NLR, PLR and CA-125 were increased in the patients with endometrioma, although increases in the NLR and PLR alone or combined did not contribute to the sensitivity or specificity of CA-125. Conclusions: The results of our study suggest that NLR and PLR did not contribute to the diagnostic value of CA-125 in the preoperative differential diagnosis of endometriomas or other benign ovarian cysts. In addition, CA-125 was not associated with clinical symptoms, although a relationship was identified between NLR and dysmenorrhea, and between PLR and lesion size, which may be the research focus of further studies.

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“…The majority of previous studies focused on the serum protein biomarkers, such as cancer antigen 125 (CA125) or human epididymis protein 4 (HE4), 8 , 9 , 10 , 11 but these biomarkers have not been adapted for clinical use for adenomyosis. Serum levels of CA125 have been shown to be increased in adenomyosis patients 12 , 13 , 14 ; however, this biomarker is typically elevated in women with other conditions, such as endometriosis, 15 , 16 or endometrial, 17 , 18 and ovarian cancers, 19 which limits its diagnostic value. 11 …”

Section: Introductionmentioning

confidence: 99%

Immunometabolic profiling of cervicovaginal lavages identifies key signatures associated with adenomyosis

Lorentzen¹,

Łaniewski²,

Cui³

et al. 2022

iScience

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CA125 modified by PLT and NLR improves the predictive accuracy of adenomyosis-derived pelvic dense adhesion

Cited by 9 publications

References 20 publications

Correlation of LOX‑5 and COX‑2 expression with inflammatory pathology and clinical features of adenomyosis

Correlation of LOX‑5 and COX‑2 expression with inflammatory pathology and clinical features of adenomyosis

The additional diagnostic value of NLR and PLR for CA-125 in the differential diagnosis of endometrioma and benign ovarian cysts in women of reproductive age: a retrospective case-control study

Immunometabolic profiling of cervicovaginal lavages identifies key signatures associated with adenomyosis

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