CA125 in peritoneal fluid of ovarian cancer patients

Vergote, I.; Onsrud, Mathias; Bormer, OP; Sert, Bilal; Moen, M

doi:10.1016/0020-7292(92)90939-g

Cited by 2 publications

(2 citation statements)

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“…Earlier studies reported that the pleural fluid CA 19-9 level had a low sensitivity but a high specificity in the diagnosis of malignant effusions [23]. We also found CA 19-9 to have a low sensitivity and a high specificity, and a similar accuracy to CYFRA 21-1 and CA 15-3. According to immunohistochemical studies, CA 125 is released from the pleura and peritoneum [24,25]. Only two reports compared CA 125 with other markers, and both found it to have a high sensitivity for discriminating malignant from benign pleural effusions, but a low specificity [23,26].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of CYFRA 21-1, CEA, CA 19-9, CA 15-3, and CA 125 Assays in Pleural Effusions: Analysis of 116 Cases and Review of the Literature

et al. 2005

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Levels of tumor markers in pleural effusions may help to establish the diagnosis of pleural malignancy, but the precise diagnostic value of each marker remains unclear. The aim of this study was to assess the diagnostic value of five common pleural fluid tumor markers, carcinoembryonic antigen (CEA), cytokeratin fragment (CYFRA) 21-1, cancer antigen (CA) 15-3, CA 19-9, and CA 125, and to review the literature from the past 15 years. Pleural fluid samples were collected prospectively from 116 patients and assayed for CEA, CYFRA 21-1, CA 15-3, CA 19-9, and CA 125 levels. A MEDLINE search of the English-language literature from the past 15 years was also done. Effusions were classified as benign or malignant on the basis of their definitive pathologic or cytologic diagnoses. The levels of all pleural tumor markers were statistically significantly higher in the malignant group than in the benign group. The marker with the highest accuracy was CEA (85.3%); CA 15-3, CYFRA 21-1, and CA 19-9 had similar accuracies (75.2%, 72.4%, and 71.5%, respectively), and CA 125 had the lowest accuracy (40.5%). On univariate analysis, tumor-marker combinations did not result in a greater accuracy than that of CEA alone. On multivariate logistic regression, CA 15-3 and CYFRA 21-1 were significant predictors of malignancy. Among the nine reports in the literature comparing 11 different tumor markers, CEA, CA 15-3, and CYFRA 21-1 yielded the best results. We conclude that pleural fluid analysis should include CEA for the diagnosis of malignancy. CA 15-3 and CYFRA 21-1 may serve as alternative options.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Value of CYFRA 21-1, CEA, CA 19-9, CA 15-3, and CA 125 Assays in Pleural Effusions: Analysis of 116 Cases and Review of the Literature

et al. 2005

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“…2,3 The extracellular domain of MUC16 is highly modified with a variety of N-and O-glycans, 4 which function as ligands for its binding partners. 5Y8 Although the molecular mechanisms by which MUC16 is released from the cell surface have not been clearly elucidated, 3,9 the ectodomain fragment(s) of MUC16 is prominently detected in serum 10,11 and peritoneal fluid 12 and has been commonly used as a diagnostic biomarker for ovarian cancer. 10,11 An elevated level of MUC16 in serum is detected in approximately 85% of patients with ovarian cancer.…”

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confidence: 99%