Ca Prostate with Oral Metastases: A Case Report and Literature Review

Mohamed, Kamal Eldein Hamed; Suleiman, Yousra Abdelmoniem

doi:10.4172/2165-7920.1000868

Cited by 2 publications

(4 citation statements)

References 9 publications

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“…In the present case, the patient reported swelling, pain, and paraesthesia (numb chin syndrome) in the right chin region, thus suggesting the involvement of the mandible. However, the swelling was also present in the right buccal mucosa, indicating that the lesion had involved not only the mandible but also the oral soft tissue, similar to a case reported by Mohamed and Suleiman [8]. The other clinical features that have been reported in oral metastasis of prostate cancer are trismus or limited mouth opening [7] and necrotic bone due to medication-induced osteonecrosis [12].…”

Section: Discussionsupporting

confidence: 77%

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Aberrant Expression of p63 in an Adenocarcinoma of the Prostate That Has Metastasized to the Oral Cavity

Khalid

Ramanathan

Lun

et al. 2022

Cureus

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Metastasis specifically to the oral cavity is uncommon in cases of prostate adenocarcinoma. Only 4% of prostate cancer patients present with metastases to the oral cavity originating from the prostate. In the oral cavity, the mandible is the primary site of metastases. p63 is said to be a reliable marker to distinguish benign from malignant lesions of prostate origin, with benign lesions staining positive and malignant lesions staining negative. However, in rare instances, malignant prostate lesions have shown aberrant expression of p63. This case report highlights such a rare incidence of metastasis of prostate adenocarcinoma to the oral cavity involving the right buccal mucosa and the right side of the mandible and having an aberrant expression of p63 in a 76-year-old Chinese male. A computed tomography (CT) scan and bone scan revealed multiple bone metastases, and in three months, the patient succumbed to the disease. Thus, p63 is not exclusively expressed in benign lesions of the prostate, as the aberrant expression may also be evident in malignant lesions such as prostate adenocarcinoma. Therefore, the determination of benign or malignant lesions of the prostate using p63 must be interpreted with caution.

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Section: Discussionsupporting

confidence: 77%

“…In this case, the patient was a known case of end-stage prostate cancer, as in cases reported previously in the literature [6][7][8]. The time interval between the diagnosis of prostate cancer and the occurrence of metastasis to the mandible ranges from 2 months [8] to 120 months [6].…”

Section: Discussionmentioning

confidence: 75%

Aberrant Expression of p63 in an Adenocarcinoma of the Prostate That Has Metastasized to the Oral Cavity

Khalid

Ramanathan

Lun

et al. 2022

Cureus

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“…In their reported case, the patient had reported having swelling, pain, and paraesthesia (numb chin syndrome) within his right chin region, which had indicated the involvement of the mandible. Nevertheless, the swelling was also not found present within his right buccal mucosa, which had suggested that the lesion had involved not only the mandible but also the oral soft tissue, which was similar to a case that had been reported by Mohamed and Suleiman [24].…”

supporting

confidence: 83%

“…The time interval between the diagnosis of prostate cancer and the occurrence of metastasis to the mandible has ranged from 2 months [24] to 120 months [22]. It was 45 months in their reported case.…”

Section: ] [23] [24] •mentioning

confidence: 83%

P63 Expressing Adenocarcinoma of The Prostate Gland, A Rare Neoplasm Which Tends to Pose Diagnostic Dilemma Sometimes: Review and Update

Kodzo-Grey Venyo

2024

JCSR

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It has been documented that prostate cancer is the world's leading cause of cancer and also the second commonest cancer in men which does tend to pose challenges in its diagnosis. It has been iterated that immunohistochemistry studies utilising tumour markers like high molecular weight cytokeratin, p63 aid in the diagnosis of prostate cancer. It has been known for some time that the absence of immunohistochemistry staining of prostate lesion for p63 and high molecular weight cytokeratin and presence of p504s in the biopsies indicate malignant lesions. Nevertheless, it had also been pointed out as well as documented that some rare cases of adenocarcinoma of prostate variants do demonstrate evidence of the tumour cells exhibiting p63 immunohistochemistry staining and this does pose a diagnostic dilemma that may make the unfamiliar pathologist mis-diagnose such a malignant tumour as a benign prostate lesion. p63-positive adenocarcinoma of the prostate gland is a major diagnostic pitfall. There is a danger of interpreting malignant glands as benign and arriving at a false-negative diagnosis. This can be prevented by the understanding of the pattern of immunohistochemistry staining expression related to this variant of prostate cancer. The major points that favour the diagnosis of carcinoma in these cases include: non-basal p63 staining and negative HWMCK and positive p504s staining. The biological behaviour of this particular rare variant of prostatic carcinoma is not certain and requires to be studied further into more detail. Considering the rarity of p63 expressing prostate cancers and the fact that most clinicians including pathologists, urologists, and oncologists would not have encountered a case of p63 expressing prostate cancer before in order to update all clinicians regarding this rare tumour, the ensuing article has been extensively written and divided into two parts: (A) Overview which has discussed general overview aspects of p63 expressing neoplasms and (B) Miscellaneous Narrations and Discussions from Some Case Reports, Case Series, and Studies Related to Primary p63 Expressing Adenocarcinomas of the Prostate Gland. A high-index of suspicion as well as knowledge of the histopathology examination features as well as immunohistochemistry examination features of this rare tumour is required from all clinicians. Knowledge of the treatment options, biological behaviour as well as outcome following treatment of the tumour has been extensively discussed as updating information. The update has clearly pointed out that further studies are required to determine the role of p63 overexpression in prognostication.

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Ca Prostate with Oral Metastases: A Case Report and Literature Review

Cited by 2 publications

References 9 publications

Aberrant Expression of p63 in an Adenocarcinoma of the Prostate That Has Metastasized to the Oral Cavity

Aberrant Expression of p63 in an Adenocarcinoma of the Prostate That Has Metastasized to the Oral Cavity

P63 Expressing Adenocarcinoma of The Prostate Gland, A Rare Neoplasm Which Tends to Pose Diagnostic Dilemma Sometimes: Review and Update

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