Ca(II), Sr(II) and Ba(II) ion interaction with the rheumatoid arthritis drug tenoxicam: Structural, thermal, and biological characterization

Abstract

Recently, one of the most common conditions that manifests as joint and muscle inflammation is rheumatoid arthritis. One of the treatments for this arthritis includes non‐steroidal anti‐inflammatory drugs (NSAIDs) of the oxicam family, and the widest used drug in this family is tenoxicam (Tenox). In this study, the complexation properties of the drug Tenox with Ca(II), Sr(II) and Ba(II) ions in a (dichloromethane + water) binary solvent system are reported. The formed metal complexes were characterized structurally, thermally, and biologically. Tenox was found to act as a chelate monoanionic ligand towards all metal ions with complexation stoichiometry of 1:2 (Metal: Tenox) for Ca(II) and Sr(II) ions, and 1:1 for Ba(II) ions. The Tenox ligand behaves as a bidentate ligand when coordinated with Sr(II) or Ba(II) ions and as a tridentate ligand when coordinated with Ca(II) ions. The Sr(II) and Ba(II) complex of the Tenox ligand exhibited marked inhibitory effect on the cell growth of the C. albicans species.

Biological and Spectroscopic Investigations of New Tenoxicam and 1.10-Phenthroline Metal Complexes

“…H 2 Ten has a ring of five-membered heteroatoms that innervates the clinical activity of the drug. Generally, H 2 Ten behaves like a bidentate ligand when it is coordinated with the metal ions by the pyridyl ring amide oxygen and nitrogen atom [9,10]. Several studies in human cancer cell lines and animal models, as well as epidemiological and clinical studies, proposed that NSAIDs require precise antineoplastic activity [11][12][13].…”

Structural insight and in silico prediction of the pharmacokinetic parameters and toxicity of alkaline earth metal compounds strontium and barium with the non-steroidal anti-inflammatory drug nimesulide

“…For example, Goia and Matijević reported the precipitation of barium naproxenate particles of different morphologies, 17 whereas Adam reported the structural, thermal, and biological characterization of Sr( ii ) and Ba( ii ) ion complexes with the rheumatoid arthritis drug tenoxicam. 18 In turn, Stahl et al determined the crystal structure of strontium diibuprofenate dihydrate, 19 while Khazaeli et al investigated the formulation of ibuprofen beads by ionotropic gelation. 20 Finally, Kobelnik et al studied dehydration and thermal decomposition of strontium and barium complexes with diclofenac.…”