CA 15-3, CRP, and LDH correlates with prognostic parameters in canine mammary neoplasms

Pinheiro, Breno Queiroz; Magalhães, Francisco Felipe de; Alves, Francisco Wesley da Silva; Silva, Isaac Neto Góes da; Faustino, Augusto; Silva, Lúcia Daniel Machado da

doi:10.1590/1984-3143-ar2022-0086

Cited by 3 publications

(1 citation statement)

References 37 publications

(60 reference statements)

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“…Pinheiro et al (2023) [27] study, female dogs with canine mammary neoplasms were found to exhibit highest serum levels of CA 15-3. The authors of this study attempted to extend currently known diagnostic procedures of canine mammary gland tumors by introducing a new non-invasive method that effectively can be used before the onset of clinical signs, or for the purpose of postoperative diagnostics, if total bilateral mastectomy is not performed.…”

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confidence: 96%

Tumor Markers in Dogs with Mammary Gland Tumors

Valencakova,

Kiselova-Bilekova,

Figurova

et al. 2023

Acta Veterinaria

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The aim of this study was to determine and compare values of carcinoembryonic antigen (CEA) and cancer antigen (CA 15-3) in 50 bitches with mammary tumors and 150 clinically healthy dogs. A modified procedure was used to determine the CEA and CA 15-3 markers with the human kits using the radioimmunoassay method (RIA). Samples collected from extirpated tumors of mammary glands were histologically processed and classified as per WHO guidelines. The mean values of the carcinoembryonic antigen markers ± SD were as follows: control group 0.89 ± 0.79, group with mammary gland tumor 1.53 ± 1.15. The values of cancer antigen markers CA 15-3 ± SD were: 1.52 ± 0.66 and 2.87 ± 1.11, respectively. The statistical significance for the carcinoembryonic antigen marker between groups was P < 0.0001. The cancer antigen CA 15-3 values between groups were also statistically significant with P < 0.0001. The results of the present study show that there are significant differences in both antigens between the control group and groups with mammary gland tumor in dogs.

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confidence: 96%

Tumor Markers in Dogs with Mammary Gland Tumors

Valencakova,

Kiselova-Bilekova,

Figurova

et al. 2023

Acta Veterinaria

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WITHDRAWN: Prospective, multicenter study investigating the acceptance and physiologic effects of a palatable and nutritionally complete food in dogs with malignant cancer

Becvarova,

Amundson,

Brejda

et al. 2023

Preprint

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Background Cancer and its treatments can be associated with loss of appetite and poor quality of life (QoL) in dogs. The objective of this single-arm, non-controlled study was to evaluate eating enthusiasm and the nutritional effects of a new food (Hill’s Prescription Diet ON-Care Canine dry) in adult dogs undergoing treatment for malignant cancer. A total of 29 eligible (≥ 1 years old, confirmed diagnosis of malignant cancer, undergoing or recently underwent conventional anticancer therapy, not on any appetite stimulants, and maintaining current medications) dogs were fed the study food for 56 days, with a 7-day transition. Intake (grams, calories), body weight (BW), body condition score (BCS; 1 = very thin, 5 = obese), muscle condition score (MCS; 1 = normal, 4 = severe loss), body fat index (BFI; 20%=low risk, 70%=extreme risk), eating enthusiasm (1 = lowest, 7 = highest), stool quality (1 = liquid, 6 = firm), blood laboratory tests, and QoL were recorded at enrollment and at specific timepoints throughout the 56 days. Results Mean age, BW, BCS, MCS and BFI at Day 0 were 10.1 y, 20.9 kg, 3.2, 1.3 and 27.2%, respectively. Twenty-three of the 29 dogs completed the study. Food (g) and caloric intake measured starting on Day 8 were unchanged throughout the study. However, dogs had a significant increase in BW (1.18 kg, SE 0.30, P = 0.0006) and BFI (3.27%, SE 1.30, P = 0.0193), and improved MCS (–0.18, SE 0.08, P = 0.0375) at Day 56. BCS remained unchanged. Eating enthusiasm remained high throughout the study. QoL assessments were high and remained unchanged except for a significant increase in affection for the family on Day 14 (P = 0.0409). Mean fecal scores ranged between 4.39 and 4.78 throughout the study. Additionally, serum 25 OH-vitamin D significantly increased by 18.1 nmol/L (SE 7.6, P = 0.0257) on Day 56. Conclusions This study demonstrated high acceptance of the study food with significant improvement of muscle condition score and significant increase in serum 25 OH-vitamin D levels, as well as maintained eating enthusiasm and QoL in dogs with malignant cancer. Thus, this new food may provide a favorable nutritional choice for maintaining weight and QoL in dogs with malignant cancer.

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