CA‐125 levels in ruptured and unruptured tubal ectopic pregnancies

Abstract

In intact tubal ectopic pregnancies, expectant or managed with medical treatment, the increase of CA-125 levels in the serial measurements could be a supplementary test for an early diagnosis of tubal rupture.

Serum concentrations of CA-125 in normal and Preeclamptic pregnancies

“…Fetal chorion, amniotic fluid and maternal decidua have been indicated as the potential sources of high serum CA-125 levels which are detected during the first trimester of pregnancy and postpartum period. This suggests disintegration of the maternal deciduas as a possible source of elevated CA125 2,3,12,13 .…”

Peritoneal relative to venous serum biomarker concentrations for diagnosis of ectopic pregnancy

“…Predantic [11] reported that patients with abortive tubal pregnancies have signiWcantly higher serum CA-125 values compared to those with viable EPs. Malatyalioglu et al [12] found that patients with ruptured tubal pregnancies have signiWcantly higher CA-125 values than those with unruptured ones, and suggested that serum CA-125 in ruptured EPs originates not only from damaged decidual cells but also from an irritated abdominal epithelium. Madendag et al [21] also found signiWcantly higher serum CA-125 levels in subjects with ruptured as compared to unruptured tubal pregnancies.…”

“…More than 20 serum biomarkers including cancer antigen 125 (CA-125), creatinine kinase (CK), vascular endothelial growth factor, and progesterone have been examined in attempts to achieve earlier diagnosis of EP [9][10][11][12]. Although these various markers have been studied extensively in subjects with EP, conXicting Wndings have been reported such that none are currently considered appropriate for diagnostic use [9,10].…”

Place de la biologie parmi les stratégies diagnostiques de la grossesse extra-utérine

“…Des travaux récents ont montré l'absence d'intérêt du dosage de CA 125 pour le diagnostic de GEU [28,29]. Cependant, il semblerait qu'une augmentation du taux de CA 125 en cas de GEU soit associé au caractère rompu de celle-ci [30,31]. Cela reste cependant à confirmer.…”