C_reactive Protein Associated With Coronary Artery Disease in Iranian Patients With Angiographically Defined Coronary Artery Disease

Kazemi-Bajestani, S.R.; Ghayour‐Mobarhan, Majid; Ebrahimi, Mansour; Moohebati, Mohsen; Esmaeili, Habib; Ferns, G.

doi:10.1016/s1567-5688(08)70910-3

Cited by 18 publications

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“…Furthermore, elevated levels of serum CRP are associated with an increased risk of cardiovascular disease, including Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity acute myocardial infarction and coronary death among individuals with angina pectoris 4 . We and others have shown that metabolic syndrome is associated with high serum CRP concentrations 5 .…”

Section: Introductionmentioning

confidence: 86%

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Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity

Ebrahimi¹,

Ghayour‐Mobarhan²,

Rezaiean³

et al. 2009

Acta Cardiologica

113

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Section: Introductionmentioning

confidence: 86%

“…We have previously reported that serum hs-CRP concentrations are strongly related to serum LDL-C concentration in serum 29 . CRP has been proposed to be actively involved in the initiation of atheromatous lesion formation 30 and the development of the mature plaque 31 .…”

Section: Heat Shock Protein Antibody Titres Coronary Risk Factors Anmentioning

confidence: 95%

Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity

Ebrahimi¹,

Ghayour‐Mobarhan²,

Rezaiean³

et al. 2009

Acta Cardiologica

113

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show abstract

“…LDL lipoprotein deposits cholesterol along the inside of artery walls, causing the formation of cholesterol plaque. This accumulation causes thickening of the artery walls and narrowing of the arteries which decreases blood flow through the narrowed area [21]. …”

Section: Discussionmentioning

confidence: 99%

Hsp70-2 gene polymorphism: susceptibility implication in Tunisian patients with coronary artery disease

et al. 2012

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Coronary artery disease (CAD) is a multifactorial disease where genetic and environmental factors interact in complex ways to cause the disease. Heat shock protein genes are involved in the progress of CAD. This implies that genetic variants of Hsp70–2 genes might contribute to the development of the CAD.Aim of studyThe aim of this study was to characterize statistical correlation of linkage between lipid profiles, polymorphism PstI site of Hsp70–2 gene and CAD.Patients and methodsThis study was carried out on Tunisian patients with CAD recruited from Hospital of Fattouma Bourguiba of Monastir-Tunisia. Polymerase chain reaction and restriction enzymes were used to determine the genotypic distributions in 252 unrelated patients and 151 healthy control subjects. Further, ApoA-I and ApoB as well as the serum total of cholesterol, HDL, triglyceride, and hs-CRP levels were measured.ResultsWe showed a decreased level of ApoA-I, whereas the levels of each of ApoB and hs-CRP were increased in patients with CAD compared with control group. In addition our studies of a polymorphic PstI site of Hsp70-2 gene at position 1267 of the Hsp70–2 gene have revealed that the allelic frequency of P2 was significantly more frequent in CAD patients than controls group (p=0.007, OR=1.495). The genotypic distribution showed a high incidence of P2/P2 genotype in CAD patients (0.190) compared to healthy control (0.009) with reach significant difference (p=0.006). The P2 carriers showed a significantly increased of Total-Cholesterol (CT) and C-reactive protein (hs-CRP) levels in CAD patients (p=0.008 and p=0.018, respectively).ConclusionThe high incidence of P2-Hsp70-2 genotype in CAD patients and the significantly association of P2/P2 genotype with elevated Total Cholesterol and hs-CRP levels, supported that P2–Hsp70–2 genotype has susceptibility implication in CAD and could increased the risk of CAD in Tunisian population.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1118340895703689

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“…The strong correlations of serum hs-CRP with LDL may be due to the putative proinflammatory effects of these two parameters which can lead to increase in the concentration of both. [17]…”

Section: Discussionmentioning

confidence: 99%

Comparison of microalbuminuria w ith hs-CRP and low density lipoprotein levels in nondiabetic, nonhypertensive myocardial infarction patients

Goud

Devi²,

Devaki

et al. 2012

Journal of Cardiovascular Disease Research

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Introduction:Microalbuminuria (MA), defined as urine albumin to urine creatinine ratio (UACR) of 30 to 300 mg/G of creatinine, is an established risk factor for cardiovascular morbidity and mortality and for end-stage renal disease in individuals with an adverse cardiovascular risk profile such as those with hypertension or/and diabetes mellitus.Materials and Methods:Thirty five patients were included in the study and equal number of age- and sex-matched controls were also included. 2 ml of venous blood was collected for hs-CRP determination and early morning mid stream urine sample was collected under strict aseptic precautions. The lipid profile was estimated in cobas autoanalyzer.Results:There was significant increase in levels of Low density lipoprotein (LDL) cholesterol, microalbumin, and hs-CRP (P< 0.001) in patients with myocardial infarction compared to healthy controls.Conclusion:Therefore, MA and hsCRP evaluation may have potential role in improving cardiovascular risk prediction, when used along with traditional lipid profiles.

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C_reactive Protein Associated With Coronary Artery Disease in Iranian Patients With Angiographically Defined Coronary Artery Disease

Cited by 18 publications

References 0 publications

Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity

Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity

Hsp70-2 gene polymorphism: susceptibility implication in Tunisian patients with coronary artery disease

Comparison of microalbuminuria w ith hs-CRP and low density lipoprotein levels in nondiabetic, nonhypertensive myocardial infarction patients

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