C609T polymorphism of the <i>NAD(P)H:quinone oxidoreductase I</i> gene does not significantly affect susceptibility for esophageal adenocarcinoma

Rahden, Burkhard H. A. von; Stein, Hubert J.; Langer, Rupert; Weyhern, C.W. Von; Schenk, Esther; Döring, C.; Siewert, J. R.; Höfler, Heinz; Sarbia, Mario

doi:10.1002/ijc.20576

Cited by 15 publications

(16 citation statements)

References 9 publications

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“…1), 10 original articles satisfied our inclusion criteria (Hamajima et al, 2002;Sarbia et al, 2003;Zhang et al, 2003aZhang et al, , 2003bvon Rahden et al, 2005;Zhang et al, 2006;Zhou et al, 2006;di Martino et al, 2007;Feng et al, 2008;Marjani et al, 2010). We found that Sarbia et al (2003) had performed 3 studies that explored the association of the NQO1 gene 609 C > T polymorphism with EC risk (Zhang et al, 2003a;von Rahden et al, 2005). In view of the ethnical differences, the EC type (esophageal squamous cell cancer and esophageal adenocarcinoma), and cases enrollment, we regarded these three studies separately.…”

Section: Identification Of Studiesmentioning

confidence: 93%

Meta-Analysis of the NAD(P)H: Quinine Oxidoreductase 1 Gene 609 C>T Polymorphism with Esophageal Cancer Risk

Wang

Zhong

2012

DNA and Cell Biology

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Association between the NAD(P)H: quinine oxidoreductase 1 (NQO1) gene 609 C>T polymorphism and esophageal cancer (EC) has been widely evaluated; however, the results are often irreproducible. We thus aimed to comprehensively evaluate this association through a meta-analysis. Data were extracted from 10 study populations involving 1390 EC patients and 1812 controls, and were analyzed using STATA software. Random-effects model was applied irrespective of between-study heterogeneity, which was assessed by the inconsistency index (I(2)) statistic. Publication bias was weighted by the funnel plot and Egger's test. Genotype distributions of the NQO1 gene 609 C>T polymorphism met Hardy-Weinberg equilibrium in controls for all studies. Allelic comparison indicated that NQO1 609 T allele conferred an increased risk (odds ratio [OR]=1.23; 95% confidence interval [CI]: 1.02-1.49; p=0.035), accompanying significant heterogeneity (I(2)=63.4%, p=0.003) and no publication bias (p(Egger)=0.391). This association was potentially enhanced in homozygous comparison (OR=1.58; 95% CI: 1.03-2.41; p=0.035; I(2)= 55.4%, p(heterogeneity)=0.017 and p(Egger)=0.461). Under dominant and recessive models, similar associations were obtained with an increased, although marginally significant risk. Subgroup analysis by ethnicity supported the risk profiles of the NQO1 gene 609 T allele and 609 TT genotype with EC in Eastern Asians, not in Europeans. Meta-regression analysis indicated that association between the NQO1 gene 609 C>T polymorphism and EC risk was significantly decreased with aging in case-patients (R(2)=-0.57; p=0.042). We expand previous studies by showing that the NQO1 gene 609 C>T polymorphism might contribute to EC occurrence, especially in Eastern Asians.

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Section: Identification Of Studiesmentioning

confidence: 93%

Meta-Analysis of the NAD(P)H: Quinine Oxidoreductase 1 Gene 609 C>T Polymorphism with Esophageal Cancer Risk

Wang

Zhong

2012

DNA and Cell Biology

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“…Of the 16 papers, two of these studies discussed different DTC (Hamajima et al, 2002;Sarbla et al, 2003) and one discussed different subpopulations , which we treated independently. Thus, a total of 21 case-control studies (Among these studies, esophageal cancer (n=7) (Hamajima et al, 2002;Sarbla et al, 2003;vov Rahden et al, 2005;Marjani et al, 2010), gastric cancer (n=5) (Hamajima et al, 2002;Hamajima et al, 2002;Sarbla et al, 2003;Li et al, 2004;Malik et al, 2011) Table 1.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

NAD(P)H: Quinone Oxidoreductase 1 (NQO1) C609T Gene Polymorphism Association with Digestive Tract Cancer: A Meta-analysis

Zhu

Huang²,

Liu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…In addition, among these eligible studies, two included populations that were selected from ESCC patients [26,29], four from EAC patients [24,27,28,30], while the other two did not clarify the histological type [25,31]. …”

Section: Resultsmentioning

confidence: 99%

NQO1 C609T polymorphism and esophageal cancer risk: a HuGE review and meta-analysis

Zhang

et al. 2013

BMC Med Genet

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BackgroundMany studies have been carried out to test the hypothesis that the NQO1 C609T polymorphism might be associated with the risk of esophageal cancer. However, the results are poorly consistent, partly due to genetic or other sources of heterogeneity. To investigate the association between this polymorphism and the risk of esophageal cancer, a meta-analysis was performed.MethodsWe used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of association. The frequency of the putative risk allele in the controls was estimated by the inverse-variance method. Cochran’s Q statistic and the inconsistency index (I2) were used to check heterogeneity. Egger’s test and an inverted funnel plot were used to assess the publication bias.ResultsOur study included eight published case-control studies about the NQO1 C609T polymorphism and esophageal cancer, including a total of 1,217 esophageal cancer patients and 1,560 controls. Overall, a significant association was found between the NQO1 C609T variant and esophageal cancer under a recessive model (OR = 1.647; 95% CI = 1.233-2.200). Regarding histological type, more significant evidence was found for esophageal squamous cell carcinoma (ESCC) (OR = 2.03; 95% CI = 1.29-3.19) than esophageal adenocarcinoma (EAC) (OR = 1.61; 95% CI = 1.01-2.56) under a recessive model.ConclusionsThe meta-analysis suggests that the NQO1 C609T polymorphism considerably increases the risk of esophageal cancer.

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C609T polymorphism of the NAD(P)H:quinone oxidoreductase I gene does not significantly affect susceptibility for esophageal adenocarcinoma

Cited by 15 publications

References 9 publications

Meta-Analysis of the NAD(P)H: Quinine Oxidoreductase 1 Gene 609 C>T Polymorphism with Esophageal Cancer Risk

Meta-Analysis of the NAD(P)H: Quinine Oxidoreductase 1 Gene 609 C>T Polymorphism with Esophageal Cancer Risk

NAD(P)H: Quinone Oxidoreductase 1 (NQO1) C609T Gene Polymorphism Association with Digestive Tract Cancer: A Meta-analysis

NQO1 C609T polymorphism and esophageal cancer risk: a HuGE review and meta-analysis

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