C5a Induces the Synthesis of IL-6 and TNF-α in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways

Ji, Mingde; Lu, Yaxin; Zhao, Cheng; Gao, Wenxing; He, Fengxia; Zhang, Jing; Zhao, Dan; Qiu, Wen; Wang, Yingwei

doi:10.1371/journal.pone.0161867

Cited by 28 publications

(24 citation statements)

References 46 publications

(43 reference statements)

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“…Moreover, the induction and maintenance of various pain conditions were activated by the ERK1/2 MAPK pathway. [2930] Recent work showed that the voltage-gated sodium channels, such as Nav1.3 and Nav1.8, can been regulated by MAPK pathway in DRG neurons and the voltage-gated sodium channels play important role in neuralgia. [3132] Consequently, we believe the migraine may be caused by cytokines, such as IL-6 and IL-1β which induced by CGRP.…”

Section: Discussionmentioning

confidence: 99%

Association of serum levels of calcitonin gene-related peptide and cytokines during migraine attacks

Han¹

2019

Ann Indian Acad Neurol

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Background: During a migraine attack, trigeminal activation results in the release of calcitonin gene-related peptide (CGRP), which stimulates the release of inflammatory cytokines playing an important role in migraine. Objective: We analyze the relation between CGRP and cytokines during attacks to explore the possible mechanism of migraine. Materials and Methods: Migraine patients and healthy control were recruited at the Department of Neurology, the Sixth People's Hospital of Fuyang City, between March 2018 and July 2018. The protein levels of interleukin (IL)-1β, IL-2, IL-6, IL-10, tumor necrosis factor-alpha (TNF-α), and CGRP were determined from the sera of patients with migraine and control subjects by enzyme-linked immunosorbent assay kits. Spearman's rank correlation coefficient was also determined to calculate the correlation between CGRP and inflammatory factors levels. Results: The level of IL-1β, IL-6, TNF-α, and CGRP in migraine group were significantly higher than normal group ( P < 0.05). The level of CGRP was significantly correlated with IL-1 β ( r = 0.30, P < 0.05) and IL-6 ( r = 0.94, P < 0.05), but not significantly correlated with IL-2 ( r =−0.047, P = 0.75), IL-10 ( r = 0.12, P = 0.43), and TNF-α ( r = 0.05, P = 0.72). Conclusions: In our study, we found migraine patients had a higher IL-6, IL-1β, and TNF level than healthy controls and the level of CGRP was related significantly with the level of IL-1β and IL-6. In conclusion, our results suggest that IL-1β and IL-6 may be involved in the pathogenesis of migraine attacks and CGRP related with the secretion of cytokines.

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Section: Discussionmentioning

confidence: 99%

Association of serum levels of calcitonin gene-related peptide and cytokines during migraine attacks

Han¹

2019

Ann Indian Acad Neurol

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“…Thus the serum IL-6 level is significantly increased. The increased IL-6 can stimulate the proliferation of mesangial cells, induce the pathological changes of glomeruli and abnormal structure and function 22 . In addition, IL-6 can stimulate the hepatocytes to produce a large number of hs-CRP, which induces or aggravates the inflammatory response 23 .…”

Section: Discussionmentioning

confidence: 99%

An experimental study of exenatide effects on renal injury in diabetic rats

Wang

Huang

et al. 2019

Acta Cir. Bras.

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Purpose To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats. Methods Fifty SD rats were randomly divided into normal control, model, exenatide-1, exenatide-2 and exenatide-3 groups, 10 rats in each group. The diabetic nephropathy model was constructed in later 4 groups. Then, the later 3 groups were treated with 2, 4 and 8 μg/kg exenatide for 8 weeks, respectively. The serum and urine biochemical indexes and oxidative stress and inflammatory indexes in renal tissue were determined. Results Compared to the model group, in exenatide-3 group the serum fasting plasma glucose and hemoglobin A1c levels were significantly decreased, the fasting insulin level was significantly increased, the renal index and blood urea nitrogen, serum creatinine and 24 h urine protein levels were significantly decreased, the renal tissue superoxide dismutase and glutathione peroxidase levels were significantly increased, the malondialdehyde level was significantly decreased, and the renal tissue tumor necrosis factor alpha, interleukin 6, hypersensitive C-reactive protein and chemokine (C-C motif) ligand 5 levels were significantly decreased P<0.05). Conclusions Exenatide can mitigate the renal injury in diabetic rats. The mechanisms may be related to its resistance of oxidative stress and inflammatory response in renal tissue.

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“…Under certain situation, mesangial cells also can secrete IL-6 and activate inflammatory cells which play an essential role in immune and metabolism-mediated injury of kidney ( 110 – 112 ). As we know, mesangial cells only express the gp130 and not the IL-6R.…”

Section: Il-6 and Immune And Inflammatory Cellsmentioning

confidence: 99%

Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update

2017

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Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies. This review provides an overview of basic concept of IL-6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells. Additionally, we summarize the roles of IL-6 in several renal diseases, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, acute kidney injury, and chronic kidney disease.

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C5a Induces the Synthesis of IL-6 and TNF-α in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways

Cited by 28 publications

References 46 publications

Association of serum levels of calcitonin gene-related peptide and cytokines during migraine attacks

Association of serum levels of calcitonin gene-related peptide and cytokines during migraine attacks

An experimental study of exenatide effects on renal injury in diabetic rats

Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update

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