C57BL/6 mice are resistant to joint degeneration induced by whole-body vibration

Kerr, Geoffrey J.; McCann, Matthew R.; Branch, Justin; Ratneswaran, A.; Pest, M.A.; Holdsworth, David W.; Beier, Frank; Dixon, S. Jeffrey; Séguin, Cheryle A.

doi:10.1016/j.joca.2016.09.020

Cited by 16 publications

(19 citation statements)

References 16 publications

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“…Further, in clinical trials evaluating the capacity of LIV to preserve bone under conditions of disease or age, no adverse event was reported relative to knee, hip or back pain. It is important to note that this research group used CD‐1 mice in their study; however, when repeating the study in C57BL/6 mice, the same strain used in our study, joint degeneration due to LIV was not detected . Nevertheless, the susceptibility of the CD‐1 mice to joint degeneration in response to LIV will be important to investigate further.…”

Section: Resultsmentioning

confidence: 83%

“…It is important to note that this research group used CD-1 mice in their study; however, when repeating the study in C57BL/6 mice, the same strain used in our study, joint degeneration due to LIV was not detected. 48 Nevertheless, the susceptibility of the CD-1 mice to joint degeneration in response to LIV will be important to investigate further. Additionally, in rats, studies have indicated that low-intensity vibration accelerates cartilage degeneration after ovariectomy 21 and anterior cruciate ligament transection.…”

Section: Low-intensity Vibration Increases Cartilage Thicknessmentioning

confidence: 99%

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Low‐intensity vibration increases cartilage thickness in obese mice

Pamon

Bhandal

Adler

et al. 2017

Journal Orthopaedic Research

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Obesity is associated with an elevated risk of osteoarthritis (OA). We examined here whether high fat diet administered in young mice, compromised the attainment of articular cartilage thickness. Further, we sought to determine if low-intensity vibration (LIV) could protect the retention of articular cartilage in a mouse model of diet-induced obesity. Five-week-old, male, C57BL/6 mice were separated into three groups (n = 10): Regular diet (RD), High fat diet (HF), and HF + LIV (HFv; 90 Hz, 0.2g, 30 min/d, 5 d/w) administered for 6 weeks. Additionally, an extended HF diet study was run for 6 months (LIV at 15 m/d). Articular cartilage and subchondral bone morphology, and sulfated GAG content were quantified using contrast agent enhanced μCT and histology. Gene expression within femoral condyles was quantified using real-time polymerase chain reaction. Contrary to our hypothesis, HF cartilage thickness was not statistically different from RD. However, LIV increased cartilage thickness compared to HF, and the elevated thickness was maintained when diet and LIV were extended into adulthood. RT-PCR analysis showed a reduction of aggrecan expression with high fat diet, while application of LIV reduced the expression of degradative MMP-13. Further, long-term HF diet resulted in subchondral bone thickening, compared to RD, providing early evidence of OA pathology-LIV suppressed the thickening, such that levels were not significantly different from RD. These data suggest that dynamic loading, via LIV, protected the retention of cartilage thickness, potentially resulting in joint surfaces better suited to endure the risks of elevated loading that parallel obesity. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:751-759, 2018.

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Section: Resultsmentioning

confidence: 83%

Section: Low-intensity Vibration Increases Cartilage Thicknessmentioning

confidence: 99%

Low‐intensity vibration increases cartilage thickness in obese mice

Pamon

Bhandal

Adler

et al. 2017

Journal Orthopaedic Research

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“…As such, physiological factors including age, sex, and genetic background may likewise affect the response of joint tissues to WBV. In fact, a recent study from our group reported a lack of WBV-induced degeneration in either the knee or intervertebral discs of C57Bl/6 mice exposed to the same protocols of WBV 54 . Taken together, these studies underscore the need for further rigorous research to assess the relative contribution of vibration parameters and physiological factors in modulating the effects of WBV on joint health.…”

Section: Discussionmentioning

confidence: 82%

Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone

McCann

Yeung

Pest

et al. 2017

Osteoarthritis and Cartilage

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“…It is important to note that CD-1 mice were used in this study, and when repeated in the C57BL/6 strain, no joint degeneration due to LIV was observed. 186 Therefore, genetic differences may be a source of contrasting results and warrant further investigation.…”

Section: Combating Obesity With Mechanical Signalsmentioning

confidence: 99%

Mechanical signals protect stem cell lineage selection, preserving the bone and muscle phenotypes in obesity

Frechette

Krishnamoorthy

Pamon

et al. 2017

Annals of the New York Academy of Sciences

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The incidence of obesity is rapidly rising, increasing morbidity and mortality rates worldwide. Associated comorbidities include type 2 diabetes, heart disease, fatty liver disease, and cancer. The impact of excess fat on musculoskeletal health is still unclear, although it is associated with increased fracture risk and a decline in muscular function. The complexity of obesity makes understanding the etiology of bone and muscle abnormalities difficult. Exercise is an effective and commonly prescribed non-pharmacological treatment option, but it can be difficult or unsafe for the frail, elderly, and morbidly obese. Exercise alternatives, such as low-intensity vibration (LIV), have potential for improving musculoskeletal health, particularly in conditions with excess fat. LIV has been shown to influence bone marrow mesenchymal stem cell differentiation toward higher-order tissues (i.e., bone) and away from fat. While the exact mechanisms are not fully understood, recent studies utilizing LIV both at the bench and in the clinic have demonstrated its efficacy. Here, we discuss the current literature investigating the effects of obesity on bone, muscle, and bone marrow and how exercise and LIV can be used as effective treatments for combating the negative effects in the presence of excess fat.

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C57BL/6 mice are resistant to joint degeneration induced by whole-body vibration

Cited by 16 publications

References 16 publications

Low‐intensity vibration increases cartilage thickness in obese mice

Low‐intensity vibration increases cartilage thickness in obese mice

Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone

Mechanical signals protect stem cell lineage selection, preserving the bone and muscle phenotypes in obesity

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