C4d Staining in the Diagnosis of C3 Glomerulopathy

Cook, H. Terence

doi:10.1681/asn.2015040433

Cited by 9 publications

(6 citation statements)

References 13 publications

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“…Additionally, it is a potential diagnostic tool for C3 glomerulonephritis or TMA. 25,26 In the present study with more than 1000 patients, we confirmed that glomerular C4d staining can also be used as a stable biomarker for disease progression in J o u r n a l P r e -p r o o f IgAN. However, before it is used in clinical practice, a number of issues need to be resolved.…”

Section: Discussionsupporting

confidence: 79%

Glomerular C4d Deposition and Kidney Disease Progression in IgA Nephropathy: A Systematic Review and Meta-analysis

et al. 2021

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Section: Discussionsupporting

confidence: 79%

Glomerular C4d Deposition and Kidney Disease Progression in IgA Nephropathy: A Systematic Review and Meta-analysis

et al. 2021

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“…Activation of complement in the classical pathway with cleavage of C4 and subsequent binding of the C4d fraction covalently to the site of activation is commonly observed in the antibody-mediated rejection pathway posttransplantation. Also, Sethi and colleagues 10 and Cook 11 proposed the use of C4d immunohistochemical staining to differentiate PIGN and C3 glomerulopathy, where C4d would be absent in C3 glomerulopathy. Immunohistochemistry for C4d was negative in the present case.…”

Section: Discussionmentioning

confidence: 99%

Atypical Plasmacytic Proliferation in a Case of C3 Glomerulopathy

Elfituri

Aardsma

Setty

et al. 2017

Journal of Investigative Medicine High Impact Case Reports

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An 11-year-old Hispanic female underwent evaluation of asymptomatic proteinuria and hematuria. The patient denied fever, edema, and gross hematuria. Urinalysis showed mild proteinuria, and a urine microscopic examination revealed red blood cells. Screening tests for glomerulonephritis revealed a low C3 and negative ANA, ASO, DNAse-B, and ANCA. Histological examination of a renal biopsy specimen showed glomeruli with endocapillary proliferation, a predominant C3 deposition in the capillary loops by immunofluorescence, and electron dense deposits in the mesangium, paramesangium, and capillary walls by electron microscopy consistent with a diagnosis of C3 glomerulopathy. An interstitial plasmacytosis was also present with focal clustering of plasma cells, which were found to be kappa light chain restricted by in situ hybridization suggestive of a clonal proliferation. One can speculate that these plasma cells may be directly responsible for the renal pathology that was seen.

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“…There is evidence that staining for C4d can distinguish C3G from immune complex-mediated GN, though its role is not established. [5][6][7] Further studies on both frozen and paraffin sections are required.…”

Section: C3gmentioning

confidence: 99%

Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

Goodship

Cook

Fakhouri

et al. 2017

Kidney International

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536

435

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In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) complement plays a primary role in disease pathogenesis. Herein we report the outcome of a 2015 Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference where key issues in the management of these 2 diseases were considered by a global panel of experts. Areas addressed included renal pathology, clinical phenotype and assessment, genetic drivers of disease, acquired drivers of disease, and treatment strategies. In order to help guide clinicians who are caring for such patients, recommendations for best treatment strategies were discussed at length, providing the evidence base underpinning current treatment options. Knowledge gaps were identified and a prioritized research agenda was proposed to resolve outstanding controversial issues.

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C4d Staining in the Diagnosis of C3 Glomerulopathy

Cited by 9 publications

References 13 publications

Glomerular C4d Deposition and Kidney Disease Progression in IgA Nephropathy: A Systematic Review and Meta-analysis

Glomerular C4d Deposition and Kidney Disease Progression in IgA Nephropathy: A Systematic Review and Meta-analysis

Atypical Plasmacytic Proliferation in a Case of C3 Glomerulopathy

Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

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