C4d in lupus nephritis and correlation with clinicopathologic findings

Malakoutian, T; Amouzegar, Atefeh; Asgari, Mojgan; Shooshtarizadeh, Tina

doi:10.15171/jnp.2018.36

Cited by 2 publications

(4 citation statements)

References 11 publications

(23 reference statements)

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“…In line with Senaldi et al and Petri et al, who discovered that serum C4d levels correlate with disease activity and rise before renal flares so they have the potential to predict the recurrence of LN, we also discovered that there was a positive correlation with SLEDAI-R and a negative cor-relation with SLEDAI-2K [17,31]. When SLE patients are followed up on, C3 and C4 levels show limited sensitivity with wide reference intervals for healthy people [32]. Martin et al discovered a negative link between C4d and both serum C3 and C4 while we found no association between serum C4d protein and either serum C3 or C4 [17].…”

Section: Roc Curvesupporting

confidence: 88%

“…C4d deposition in glomerular capillaries of LN does not indicate the current disease activity but may be a useful marker to predict the prognosis of LN, according to research by Tahereh Malakoutian and colleagues who examined the staining of C4d positivity in renal biopsy of 72 patients with different classes of LN. Additionally, there was no connection seen between the low complement levels and C4d positive [32].…”

Section: Roc Curvementioning

confidence: 76%

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Serum S100P and C4d proteins as markers for active proliferative lupus nephritis in Egyptian patients with systemic lupus erythematosus

Elnokeety,

Khalil,

Fayed

2023

Ukr. J. Nephrol. and Dial.

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Lupus nephritis (LN), occurring in approximately 50% of individuals with systemic lupus erythematosus (SLE), significantly influences therapy and prognosis. Proliferative LN, more prevalent than non-proliferative LN, is associated with a poorer prognosis. This study aimed to investigate the potential correlation between serum levels of the pro-inflammatory proteins human calcium-binding S100P (S100P) and Human complement Fragment 4 (C4d) and confirmed proliferative LN through biopsy. The objective was to evaluate their reliability as biomarkers for disease activity in proliferative LN. Methods. Serum S100P and C4d were measured using enzyme-linked immunosorbent assay in 100 female patients with established SLE. Among these, 50 had confirmed proliferative LN through biopsy, and 50 did not. A control group of 50 healthy female donors' plasma samples was included. Results. SLE patients with proliferative LN exhibited significantly higher serum levels of S100P (P < 0.001) and C4d (P < 0.001) compared to SLE patients without LN and controls. Serum S100P demonstrated a significantly higher positive correlation with the activity index in renal biopsies (r = 0.784) compared to serum C4d (r = 0.416). Additionally, serum S100P had a significantly higher positive correlation with SLEDAI-R than serum C4d (r = 0.651 vs. r = 0.257). Both serum S100P and C4d showed promise as reliable biomarkers for the diagnosis of active proliferative LN, as indicated by the ROC curve and AUC assessments. Conclusion. Serum concentrations of S100P and C4d emerge as useful indicators for identifying SLE patients with active proliferative LN.

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Section: Roc Curvesupporting

confidence: 88%

Section: Roc Curvementioning

confidence: 76%

Serum S100P and C4d proteins as markers for active proliferative lupus nephritis in Egyptian patients with systemic lupus erythematosus

Elnokeety,

Khalil,

Fayed

2023

Ukr. J. Nephrol. and Dial.

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“…Extraglomerular staining in peritubular capillaries (PTCs) and arterioles has been recorded especially in LN and hemolytic uremic syndrome (HUS). [5][6][7] In combination with C1q, C4d stain can help in delineating various complement pathway activation and potentially assist in the prognostication of various renal diseases which can influence treatment outcomes. 8 With this knowledge of C4d staining patterns in various glomerular diseases, our group wanted to assess the utility of C4d as an ancillary technique in addition to routine light microscopy, IF studies, and ultrastructural evaluation in our tertiary care center.…”

Section: Introductionmentioning

confidence: 99%

“…Extraglomerular staining in peritubular capillaries (PTCs) and arterioles has been recorded especially in LN and hemolytic uremic syndrome (HUS). 5-7 In combination with C1q, C4d stain can help in delineating various complement pathway activation and potentially assist in the prognostication of various renal diseases which can influence treatment outcomes. 8…”

Section: Introductionmentioning

confidence: 99%

Utility of C4d Immunohistochemistry as an Adjunct Stain in Diagnostic Renal Pathology of Glomerular Diseases

Pradeep

Srinivas

2023

Int J Surg Pathol

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C4d is a byproduct of the activation of the classic and lectin complement pathways. Being routinely used as a marker for antibody-mediated rejection, the significance of C4d in native kidney disease is currently being widely studied. We evaluated glomerular and extraglomerular C4d staining in 82 biopsies of proliferative and nonproliferative glomerulonephritis diagnosed in our institution. The staining pattern of C4d was tabulated in various glomerular diseases. All biopsies of membranous nephropathy including membranous lupus nephritis (Class V) and immune complex-mediated membranoproliferative glomerulonephritis (MPGN) consistently showed C4d deposits along glomerular basement membrane mirroring the location of immunoglobulin and complement in these conditions. Conversely, other glomerular diseases like IgA nephropathy, postinfectious glomerulonephritis, focal segmental glomerulosclerosis, minimal change disease, and diabetic nephropathy showed variable mesangial and capillary wall C4d deposits. To summarize, the consistent pattern of C4d staining in membranous nephropathy (primary and secondary)and immune complex-mediated MPGN can be used as a valuable adjunct tool in establishing the diagnosis, especially when immunofluorescence findings are limited by inadequate sampling.C4d reactivity in other glomerular diseases are variable and may not aid as a diagnostic tool in renal biopsy evaluation.

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C4d in lupus nephritis and correlation with clinicopathologic findings

Cited by 2 publications

References 11 publications

Serum S100P and C4d proteins as markers for active proliferative lupus nephritis in Egyptian patients with systemic lupus erythematosus

Serum S100P and C4d proteins as markers for active proliferative lupus nephritis in Egyptian patients with systemic lupus erythematosus

Utility of C4d Immunohistochemistry as an Adjunct Stain in Diagnostic Renal Pathology of Glomerular Diseases

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