C4d deposition is associated with immune cells infiltrating in kidney allograft glomerulitis and peritubular capillaritis

Jin, Juan; Li, Yi Wen; He, Qing

doi:10.3109/0886022x.2015.1033368

Cited by 3 publications

(3 citation statements)

References 39 publications

(46 reference statements)

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“…As shown in Supplementary Table 1, http://links.lww.com/CM9/A726, the glomerulonephritis and peritoneal capillaritis scores of AMR cases were significantly higher than that of all the other diagnoses. It has been reported that the total number of infiltrating cells in glomeruli and PTC are associated with PTC C4d+ and that infiltrating cells in glomeruli and PTC are predominantly macrophages and T cells with a completely cytotoxic phenotype [15] . Both macrophages and cytotoxic T cells can damage endothelial cells and induce lectin-mediated complement pathway activation, [11] which findings support our results.…”

Section: Discussionsupporting

confidence: 91%

“…It has been reported that the total number of infiltrating cells in glomeruli and PTC are associated with PTC C4d+ and that infiltrating cells in glomeruli and PTC are predominantly macrophages and T cells with a completely cytotoxic phenotype. [ 15 ] Both macrophages and cytotoxic T cells can damage endothelial cells and induce lectin-mediated complement pathway activation, [ 11 ] which findings support our results.…”

Section: Discussionsupporting

confidence: 86%

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Donor-specific antibodies, glomerulitis, and human leukocyte antigen B eplet mismatch are risk factors for peritubular capillary C4d deposition in renal allografts

Zheng

Guo

Gong

et al. 2021

Chinese Medical Journal

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Background: The complement system plays an important role in the immune response to transplantation, and the diagnostic significance of peritubular capillary (PTC) C4d deposition (C4d+) in grafts is controversial. The study aimed to fully investigate the risk factors for PTC C4d+ and analyze its significance in biopsy pathology of kidney transplantation. Methods: This retrospective study included 124 cases of kidney transplant with graft biopsy and donor-specific antibody (DSA) testing from January 2017 to December 2019 in a single center. The effects of recipient pathological indicators, eplet mismatch (MM), and DSAs on PTC C4d+ were examined using univariate and multivariate logistic regression analyses. Results: In total, 35/124 (28%) were PTC C4d+, including 21 with antibody-mediated rejection (AMR), eight with renal tubular injury, three with T cell-mediated rejection, one with glomerular disease, and two others. Univariate analysis revealed that DSAs ( P < 0.001), glomerulitis ( P < 0.001), peritubular capillaritis ( P < 0.001), and human leukocyte antigen (HLA) B eplet MM ( P = 0.010) were the influencing factors of PTC C4d+. According to multivariate analysis, DSAs (odds ratio [OR]: 9.608, 95% confidence interval [CI]: 2.742–33.668, P < 0.001), glomerulitis (OR: 3.581, 95%CI: 1.246–10.289, P = 0.018), and HLA B eplet MM (OR: 1.166, 95%CI: 1.005–1.353, P = 0.042) were the independent risk factors for PTC C4d+. In receiver operating characteristic curve analysis, the area under the curve was increased to 0.831 for predicting PTC C4d+ when considering glomerulitis, DSAs, and HLA B eplet MM. The proportions of HLA I DSAs and PTC C4d+ in active antibody-mediated rejection were 12/17 and 15/17, respectively; the proportions of HLA class II DSAs and PTC C4d+ in chronic AMR were 8/12 and 7/12, respectively. Furthermore, the higher the PTC C4d+ score was, the more serious the urinary occult blood and proteinuria of recipients at the time of biopsy. Conclusions: PTC C4d+ was mainly observed in AMR cases. DSAs, glomerulitis, and HLA B eplet MM are the independent risk factors for PTC C4d+.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 86%

Donor-specific antibodies, glomerulitis, and human leukocyte antigen B eplet mismatch are risk factors for peritubular capillary C4d deposition in renal allografts

Zheng

Guo

Gong

et al. 2021

Chinese Medical Journal

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“…Interestingly, C4d deposits was evident in the region of mononuclear cell accumulations (Figure 5). Deposition of C4d has been recognized to be associated with granzyme B–positive T cells in transplant glomerulitis, 34 adding new dimensions to the regulatory effects of complement on cytotoxic T cell–derived damage. Moreover, allograft recipients who received burixafor treatment had lower plasma levels of CRP relative to the levels of those in the control group (Figure 5C).…”

Section: Discussionmentioning

confidence: 99%

CXCR4 Antagonist Reduced the Incidence of Acute Rejection and Controlled Cardiac Allograft Vasculopathy in a Swine Heart Transplant Model Receiving a Mycophenolate-based Immunosuppressive Regimen

et al. 2018

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The prognostic significance of glomerular infiltrating leukocytes during acute renal allograft rejection

Sentís

Kers

Yapici

et al. 2015

Transplant Immunology

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C4d deposition is associated with immune cells infiltrating in kidney allograft glomerulitis and peritubular capillaritis

Abstract: Objective: The aim of our study was to determine the amount and composition of immune cells within glomeruli and PTCs and its relationship with C4d deposition.

Cited by 3 publications

References 39 publications

Donor-specific antibodies, glomerulitis, and human leukocyte antigen B eplet mismatch are risk factors for peritubular capillary C4d deposition in renal allografts

Donor-specific antibodies, glomerulitis, and human leukocyte antigen B eplet mismatch are risk factors for peritubular capillary C4d deposition in renal allografts

CXCR4 Antagonist Reduced the Incidence of Acute Rejection and Controlled Cardiac Allograft Vasculopathy in a Swine Heart Transplant Model Receiving a Mycophenolate-based Immunosuppressive Regimen

The prognostic significance of glomerular infiltrating leukocytes during acute renal allograft rejection

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