C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome

Sato, Yuichiro; Yamaguchi, Tomoko; Muraoka, Jyunsuke; Taniguchi, Hajime; Kisanuki, Atsushi; Maekawa, Kazunari; Yamashita, Atushi; Aman, Murasaki; Kodama, Yasuo; Sameshima, Hiroshi; Asada, Yujiro

doi:10.1155/2019/5863476

Cited by 4 publications

(3 citation statements)

References 13 publications

(21 reference statements)

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“…Detection of deposited C4d complexes is considered nowadays to be the gold standard for the diagnosis of acute humoral resection of kidney transplantation [79]. However, further research is needed to demonstrate the usefulness of C4d deposition as a new NLE marker [80].…”

Section: Characteristics Of Neonatal Lupusmentioning

confidence: 99%

“…It is suggested that C4d could be used as a biomarker used to evaluate the future risk of FGR and to control the disease during pregnancy in the case of these patients [81]. In summary, Sato et al determined the diagnosis of the newborn on the basis of skin symptoms, antibody levels in the serum of the newborn and mother, and histopathological examinations of the placenta [80].…”

Section: Characteristics Of Neonatal Lupusmentioning

confidence: 99%

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An Overview of Neonatal Lupus with Anti-Ro Characteristics

Gryka-Marton

Szukiewicz

Teliga-Czajkowska

et al. 2021

IJMS

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Neonatal lupus erythematosus (NLE) is a syndrome of clinical symptoms observed in neonates born to mothers with antibodies to soluble antigens of the cell nucleus. The main factors contributing to the pathogenesis of this disease are anti-Sjögren Syndrome A (anti-SS-A) antibodies, known as anti-Ro, and anti-Sjögren Syndrome B (anti-SS-B) antibodies, known as anti-La. Recent publications have also shown the significant role of anti-ribonucleoprotein antibodies (anti-RNP). Seropositive mothers may have a diagnosed rheumatic disease or they can be asymptomatic without diagnosis at the time of childbirth. These antibodies, after crossing the placenta, may trigger a cascade of inflammatory reactions. The symptoms of NLE can be divided into reversible symptoms, which concern skin, hematological, and hepatological changes, but 2% of children develop irreversible symptoms, which include disturbances of the cardiac stimulatory and conduction system. Preconceptive care and pharmacological prophylaxis of NLE in the case of mothers from the risk group are important, as well as the monitoring of the clinical condition of the mother and fetus throughout pregnancy and the neonatal period. The aim of this manuscript is to summarize the previous literature and current state of knowledge about neonatal lupus and to discuss the role of anti-Ro in the inflammatory process.

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Section: Characteristics Of Neonatal Lupusmentioning

confidence: 99%

Section: Characteristics Of Neonatal Lupusmentioning

confidence: 99%

An Overview of Neonatal Lupus with Anti-Ro Characteristics

Gryka-Marton

Szukiewicz

Teliga-Czajkowska

et al. 2021

IJMS

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show abstract

“…Более того, C4d является общепринятым биомаркером при опосредованном антителами отторжении трансплантата, а также играет роль в опосредованных антителами осложнениях беременности. Интересно, что плацентарный C4d, обнаруживаемый в большинстве случаев системной красной волчанки и антифосфолипидного синдрома, диффузно экспрессируется в синцитиотрофобласте [3].…”

Section: Discussionunclassified

Clinical case of neonatal lupus with cartilaginous metaplasia, fibrosis and calcification of the atrioventricular node zone

Давыдов

Makarov

Morozov

et al. 2023

Vestnik aritmologii

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Neonatal lupus is a rare disease associated with the circulation in the mother’s blood of one or more autoantibodies to soluble intracellular ribonucleoproteins Ro/SS-A and La/SS-B. This disease is extremely often manifested by congenital heart block, which can progress even after the birth of a child. We have described a case of fibrosis, calcification and cartilaginous metaplasia of the atrioventricular node zone, which caused complete atrioventricular block in a child who died from neonatal lupus.

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Gynaecologic and obstetric aspects in Sjögren’s syndrome

Priori¹,

Minniti²,

Colafrancesco³

2021

Oxford Textbook of Sjögren's Syndrome

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Although primary Sjögren’s syndrome (SS) mainly affects women, its gynaecological, obstetric, and sexual aspects have been largely overlooked. Data regarding the impact of the disease on pregnancy and vice versa are scant. Primary SS can occur in all age groups but usually starts after the fifth decade, often beyond the childbearing age; however, at least in the Western world, the age of first pregnancy is increasingly delayed, so pregnancy in SS is being encountered more frequently. Vaginal dryness represents the main cause of dyspareunia, which seriously affects individuals’ quality of life, but data regarding this aspect of the disease are scarce. In this chapter we review the main gynaecologic complications of SS, focusing on their prevalence and impact on daily life. In addition we review pregnancy outcome in primary SS including obstetric complications, pregnancy outcome, and manifestations of neonatal lupus.

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C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome

Cited by 4 publications

References 13 publications

An Overview of Neonatal Lupus with Anti-Ro Characteristics

An Overview of Neonatal Lupus with Anti-Ro Characteristics

Clinical case of neonatal lupus with cartilaginous metaplasia, fibrosis and calcification of the atrioventricular node zone

Gynaecologic and obstetric aspects in Sjögren’s syndrome

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