C4 article: Implications of COVID-19 in transplantation

Aaron, Justin G.; Abbo, Lilian M.; Alconchel, Felipe; Amarelli, Cristiano; Anjan, Shweta; Ardura, Monica I.; Azar, Marwan M.; Azzi, Jamil; Baddley, John W.; Balliet, Wendy; Bellini, Maria Irene; Blumberg, Emily A.; Blumenthal, James A.; Bruschwein, Heather; Danziger‐Isakov, Lara; Demekhin, Valerie; Dulek, Daniel E.; Ferreira, Gustavo Fernandes; Gambella, Alessandro; Giorgakis, Emmanouil; Gitman, Melissa R.; Goff, Kristina; Green, Michael; Greenwald, Melissa A.; Hand, Jonathan; Hemmersbach‐Miller, Marion; Humar, Atul; Ison, Michael G.; Jaramillo, Andrés; Jesse, Michelle T; Kotton, Camille Nelson; Kronsnoble, Kristin; Kumar, Deepali; Hoz, Ricardo M. La; Lentine, Krista L.; Lopez, Santiago M C; Miko, Benjamin A.; Mohan, Sumit; Murakami, Naoka; Niles, Patti; Nolan, Annelise; Nonterah, Camilla W.; Park, Jeong Mi; Madan, Rebecca Pellett; Pereira, Marcus R.; Villalobos, Armelle Pérez Cortés; Pilch, Nicole A.; Potter, Lisa; Rodrigue, James R.; Schmiedeskamp-Rahe, Mia; Sharma, Dhruva; Sholkamy, Amany; Singh, Neeraj; Tantisattamo, Ekamol; Tezer, Yasemin; Theodoropoulos, Nicole; Truax, Crystal; Valdepenas, Benito; Verran, Deborah; Westphal, Scott G.; Woodside, Kenneth J.

doi:10.1111/ajt.16346

Cited by 16 publications

(9 citation statements)

References 84 publications

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“…In parallel with the pandemic phases, we could identify three different approaches that have been adopted to carry on the necessary surgical activity [ 44 ]: Significant flattening of the observed pandemic curve allows a partial reopening. This includes a stable number of new cases and some stabilization in ward/ICU bed utilization (orange zone) The number of new COVID cases is flat or decreasing for a reasonable period, and ICU and ward bed utilization has been at a stable level at the transplant hospital (yellow zone) Prolonged stability and/or a decrease in COVID activity is observed along with prolonged stability or a decrease in hospital ICU/ward bed utilization.…”

Section: Liver Transplantation In Covid-19: What the Pandemic Implied For Transplant Programsmentioning

confidence: 99%

Liver Transplant Imaging prior to and during the COVID-19 Pandemic

Bellini

Fresilli

Lauro

et al. 2022

BioMed Research International

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Background. The suspension of the surgical activity, the burden of the infection in immunosuppressed patients, and the comorbidities underlying end-stage organ disease have impacted transplant programs significantly, even life-saving procedures, such as liver transplantation. Methods. A review of the literature was conducted to explore the challenges faced by transplant programs and the adopted strategies to overcome them, with a focus on indications for imaging in liver transplant candidates. Results. Liver transplantation relies on an appropriate imaging method for its success. During the Coronavirus Disease 2019 (COVID-19) pandemic, chest CT showed an additional value to detect early signs of SARS-CoV-2 infection and other screening modalities are less accurate than radiology. Conclusion. There is an emerging recognition of the chest CT value to recommend its use and help COVID-19 detection in patients. This examination appears highly sensitive for liver transplant candidates and recipients, who otherwise would have not undergone it, particularly when asymptomatic.

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Section: Liver Transplantation In Covid-19: What the Pandemic Implied For Transplant Programsmentioning

confidence: 99%

Liver Transplant Imaging prior to and during the COVID-19 Pandemic

Bellini

Fresilli

Lauro

et al. 2022

BioMed Research International

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“…No other COVID-19 therapies, including convalescent plasma, are recommended in the post-liver transplant period. [115][116][117] Apart from these standards of care, specific treatment and management considerations need to be exercised in liver transplant recipients. This includes stopping mycophenolate mofetil in those with documented lymphopenia (a marker of severe and progressive disease or a drug-induced adverse event).…”

Section: Covid-19 Treatment In Liver Transplant Recipientsmentioning

confidence: 99%

“…Drugs such as statins, ACE inhibitors, and angiotensin receptor blockers should be continued. 115 , 116 For those receiving supplemental oxygen, HFNC, or NIV, dexamethasone is recommended. For those requiring mechanical ventilation or ECMO, low-dose dexamethasone but not remdesivir is suggested.…”

Section: Treatment and Managementmentioning

confidence: 99%

Critical Update on the Diagnosis and Management of COVID-19 in Advanced Cirrhosis and Liver Transplant Recipients

Philips¹,

Rela²,

Soin³

et al. 2021

Journal of Clinical and Translational Hepatology

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The novel coronavirus disease 2019 (COVID-19) pandemic has impacted health care worldwide, with specific patient populations, such as those with diabetes, cardiovascular disease, and chronic lung disease, at higher risk of infection and others at higher risk of disease progression. Patients with decompensated cirrhosis fall into the latter category and are a unique group that require specific treatment and management decisions because they can develop acute-on-chronic liver failure. In liver transplant recipients, the atypical immunity profile due to immunosuppression protects against downstream inflammatory responses triggered by COVID-19. This exhaustive review discusses the outcomes associated with COVID-19 in patients with advanced cirrhosis and in liver transplant recipients. We focus on the immunopathogenesis of COVID-19, its correlation with the pathogenesis of advanced liver disease, and the effect of immunosuppression in liver transplant recipients to provide insight into the outcomes of this unique patient population.

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“…Concerns about potential donor-to-recipient transmission, screening strategies, posttransplant management, ethics and legal issues, and more caused great uncertainty and even led to a temporary suspension of nonvital transplants. 7 , 8 …”

Section: Introductionmentioning

confidence: 99%

Solid Organ Donation and Transplantation Activity in the Eurotransplant Area During the First Year of COVID-19

et al. 2022

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Background. Transplantation activity during the first wave of the coronavirus disease 2019 (COVID-19) pandemic was severely affected worldwide. This retrospective analysis aimed to assess the impact of COVID-19 on organ donations and transplantations in the Eurotransplant region during the first 12 mo of the pandemic. Specifically, we compared donor and transplantation numbers during both waves to determine whether transplant systems adapted to this new reality. Methods. All reported organ donations and transplantations from March 1, 2015, to February 28, 2021, were collected from the Eurotransplant International Foundation registry. The observation period from 2020 to 2021 was divided into three 4-mo periods, which were then compared with the corresponding periods of the preceding 5 y. COVID-19 cases for Eurotransplant countries were retrieved from the OurWorldInData.org database. Results. Overall, the number of organ donors decreased by 18.3% ( P < 0.0001) and the number of organ transplantations by 12.5% ( P > 0.0001) compared with previous years. Pancreas transplantation was the most affected, followed by kidney, liver, heart, and lung transplant. In detail, during period 1, the number of organ donors decreased by 26.2% ( P < 0.0001) and the number of organ transplantations by 16.5% ( P < 0.0001), in period 2 by 5.5% ( P < 0.0091) and 4.9% ( P < 0.0001), and in period 3 by 23.1% ( P < 0.0001) and 16.4% ( P < 0.0001), respectively. Conclusions. Organ donation and transplantation decreased drastically also during the second wave; however, despite the severity of the second wave, the decline was comparable with that of the first wave.

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C4 article: Implications of COVID-19 in transplantation

Cited by 16 publications

References 84 publications

Liver Transplant Imaging prior to and during the COVID-19 Pandemic

Liver Transplant Imaging prior to and during the COVID-19 Pandemic

Critical Update on the Diagnosis and Management of COVID-19 in Advanced Cirrhosis and Liver Transplant Recipients

Solid Organ Donation and Transplantation Activity in the Eurotransplant Area During the First Year of COVID-19

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