2008
DOI: 10.1242/dev.016725
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C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment

Abstract: Neuronal migration is integral to the development of the cerebral cortex and higher brain function. Cortical neuron migration defects lead to mental disorders such as lissencephaly and epilepsy. Interaction of neurons with their extracellular environment regulates cortical neuron migration through cell surface receptors. However, it is unclear how the signals from extracellular matrix proteins are transduced intracellularly. We report here that mouse embryos lacking the Ras family guanine nucleotide exchange f… Show more

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Cited by 80 publications
(78 citation statements)
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References 56 publications
(88 reference statements)
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“…RapGef1-deficient mouse embryos exhibit a cortical neuron migration defect resulting in a failure to split the preplate into marginal zone and subplate and a failure to form a cortical plate (27). Quantitative RT-PCR of RAPGEF1 in CLN3-depleted cells confirmed the significant increase in mRNA expression in CLN3 patients with rapid progression.…”
Section: Identification Of Potential Modifier Genes For Cln3 Diseasementioning
confidence: 74%
“…RapGef1-deficient mouse embryos exhibit a cortical neuron migration defect resulting in a failure to split the preplate into marginal zone and subplate and a failure to form a cortical plate (27). Quantitative RT-PCR of RAPGEF1 in CLN3-depleted cells confirmed the significant increase in mRNA expression in CLN3 patients with rapid progression.…”
Section: Identification Of Potential Modifier Genes For Cln3 Diseasementioning
confidence: 74%
“…Other proteins such as Nck␤ and Lis1 may also be present and could be phosphorylated by the associated SFK. Which of the bound proteins is required for proper migration remains to be discovered, although a recent study of C3G mutant mice showed that C3G is needed for the normal migration of cortical neurons in vivo (39), suggesting that C3G phosphorylation may be crucial.…”
Section: Resultsmentioning
confidence: 99%
“…Although additional experiments are required to identify these cues, they might include extracellular matrix (ECM) components. The SP is rich in ECM components (Henke-Fahle et al, 1996;Voss et al, 2008), which can modulate axonal responses to guidance cues (Höpker et al, 1999;Nguyen-Ba-Charvet et al, 2001;Kantor et al, 2004).…”
Section: Npn-2 Controls Mpfc Innervation Through the External Capsulementioning
confidence: 99%