C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis

Lin, Longnian; Zhang, Rui Yan; Wang, Xiao Qun; Liu, Zhu Hui; Shen, Ying; Ding, Feng; Meng, Hua; Wang, Ling Jie; Yan, Xin; Yang, Ke; Wang, Hai Bo; Li, Pu; Zhang, Qi; Chen, Qiujing; Caterina, Raffaele De; Shen, Wei Feng

doi:10.1093/eurheartj/ehv649

Cited by 84 publications

(77 citation statements)

References 24 publications

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“…In our study, no significant difference of BMI was found between the CHF group and the control group. This result was consistent with a previous study reported by Lin Lu, who speculated that the inflammatory status might be a stronger stimulator to CTRP1 secretion in CHF than the adipose tissue mass [24, 25]. Moreover, some patients with CHF could have gained weight due to water-sodium retention.…”

Section: Discussionsupporting

confidence: 92%

Association Between C1q/TNF-Related Protein-1 Levels in Human Plasma and Epicardial Adipose Tissues and Congestive Heart Failure

Yang¹,

Liu

Zhang

et al. 2017

Cell Physiol Biochem

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Background/Aims: C1q and tumour necrosis factor-related protein 1 (CTRP1) possesses anti-atherogenic and anti-inflammatory effects. This study investigated whether the CTRP1 levels in the plasma and epicardial adipose tissue (EAT) were associated with congestive heart failure (CHF) and to disclose possible molecular mechanisms. Methods: Plasma and tissue samples were obtained from subjects with or without CHF. Plasma levels of CTRP1 were measured by ELISA. The mRNA levels of CTRP1 and inflammatory cytokines were detected by RT-PCR. The protein levels of CTRP1, aldosterone synthase (CYP11B2) and mitogen-activated protein kinase were examined by Western blotting. Results: The levels of CTRP1 in the plasma and EAT were higher in the CHF patients than those in the controls. There were no differences in the CTRP1 levels in cardiomyocytes between the CHF group and the non-CHF group. An exploratory survival analysis showed that higher CTRP1 values at admission were associated with a worse prognosis after discharge. CTRP1 increased the IL-6 mRNA level in H295R cells. CTRP1 recruited ERK1/2 and Jak-2 for aldosterone release by modulating the CYP11B2 protein level, and brain natriuretic peptide repressed the CTRP1-induced aldosterone release through the JAK2-STAT3 signalling pathways. Conclusion: The CTRP1 levels in the plasma and EAT were increased in the CHF patients. CTRP1 is involved in the pathogenesis of CHF by modulating IL-6 levels and aldosterone release.

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Section: Discussionsupporting

confidence: 92%

Association Between C1q/TNF-Related Protein-1 Levels in Human Plasma and Epicardial Adipose Tissues and Congestive Heart Failure

Yang¹,

Liu

Zhang

et al. 2017

Cell Physiol Biochem

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“…First, we examined only CTRP9 based on its high similarity to adiponectin and the abundance in experimental evidence of its vascular effects [10–14]. Since CTRP1 [39] and CTRP3 [34, 40] were also indicated to be linked to atherosclerosis, the other members of the CTRP family need to be examined in the future. Second, because this was a cross-sectional study, a causal relationship between CTRP9 and carotid atherosclerosis could not be confirmed.…”

Section: Discussionmentioning

confidence: 99%

Plasma C1q/TNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction

Asada

Morioka

Yamazaki

et al. 2016

Journal of Diabetes Research

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Aim. C1q/tumor necrosis factor-related protein-9 (CTRP9), a paralog of adiponectin, is expressed in adipose tissue. CTRP9 exerts protective effects against obesity and atherosclerosis in rodents. We investigated the association between plasma CTRP9 levels and atherosclerosis in patients with type 2 diabetes. Methods. We included 419 patients with type 2 diabetes, 161 of whom had chronic kidney disease (CKD). Fasting plasma CTRP9 and total adiponectin levels were measured with enzyme-linked immunosorbent assay. The intima-media thickness (IMT) of the common carotid artery was measured with ultrasonography. Results. Plasma CTRP9 levels were higher in the CKD group than in the non-CKD group. Plasma CTRP9 levels were positively correlated with carotid IMT in the non-CKD group. Multivariate analyses revealed that plasma CTRP9 levels were positively associated with carotid IMT in the non-CKD group, independent of age, sex, body mass index, adiponectin, and other cardiovascular risk factors. However, plasma CTRP9 levels were not associated with carotid IMT in the CKD group. Conclusion. Plasma CTRP9 levels are associated with atherosclerosis in diabetic patients without CKD, independently of obesity, adiponectin, and traditional cardiovascular risk factors. This study indicates a potential role of CTRP9 in atherosclerosis progression in human type 2 diabetes.

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“…Our efforts to identify novel regulators of metabolism have led to the identification and characterization of C1q/TNF-related proteins (CTRP1-15), secreted proteins of the C1q family conserved from fish to human. [6][7][8] In vivo animal studies highlight important metabolic, [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] cardiovascular, [26][27][28][29][30][31][32][33][34][35][36] and inflammatory 12,13,[37][38][39][40] functions for multiple family members.…”

Section: Introductionmentioning

confidence: 99%

“…14,19,24 Correlative human studies also support a role for CTRP1 as an adipokine with cardio-metabolic function. Elevated plasma levels of CTRP1 are found in patients with type 2 diabetes and metabolic syndrome, [41][42][43][44][45] non-alcoholic fatty liver disease, 46 coronary artery and heart disease, 33,[47][48][49][50][51] and hypertension. 52,53 The direct causal or compensatory role of CTRP1 in human pathophysiology, however, is often unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Whereas loss of CTRP1 exacerbates cardiac ischemia/reperfusion injury in mice, 32 it attenuates atherosclerosis in apolipoprotein E-deficient animals. 33 Whether CTRP1 has a role in organ systems beside adipose tissue, liver, skeletal muscle, and heart is unknown. In characterizing this protein more fully, we noted novel roles for CTRP1 in renal function in a Ctrp1 knockout (KO) mouse model.…”

Section: Introductionmentioning

confidence: 99%

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Late‐onset renal hypertrophy and dysfunction in mice lacking CTRP1

et al. 2019

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diameter at end of diastole; LVESD, LV chamber diameter at end of systole; PWTED, posterior wall thickness at end of diastole; PWV, pulse wave velocity; RWT, relative wall thickness; SV, stroke volume; WT, wild-type. AbstractLocal and systemic factors that influence renal structure and function in aging are not well understood. The secretory protein C1q/TNF-related protein 1 (CTRP1) regulates systemic metabolism and cardiovascular function. We provide evidence here that CTRP1 also modulates renal physiology in an age-and sex-dependent manner. In mice lacking CTRP1, we observed significantly increased kidney weight and glomerular hypertrophy in aged male but not female or young mice. Although glomerular filtration rate, plasma renin and aldosterone levels, and renal response to water restriction did not differ between genotypes, CTRP1-deficient male mice 2658 | RODRIGUEZ Et al.

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C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis

Abstract: C1q/TNF-related protein-1 is a marker of atherosclerosis in humans and promotes atherogenesis in mice.

Cited by 84 publications

References 24 publications

Association Between C1q/TNF-Related Protein-1 Levels in Human Plasma and Epicardial Adipose Tissues and Congestive Heart Failure

Association Between C1q/TNF-Related Protein-1 Levels in Human Plasma and Epicardial Adipose Tissues and Congestive Heart Failure

Plasma C1q/TNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction

Late‐onset renal hypertrophy and dysfunction in mice lacking CTRP1

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