C1q Intrathecal synthesis in patients without inflammatory diseases with blood‐brain dysfunction

Abstract

The role of complement system in the central nervous system is not enough clarified. For this reason it requires to know what happen in extreme situations. The objective is to know if under blood‐cerebrospinal fluid dysfunction how the classical complement pathway by analyzing C1q is possible to be intrathecally synthesized. It should consider three topics: the molecular size dependent concentration between CSF and blood. The transfer variation between blood and CSF and, and the CSF C1q concentration correlation with the albumin CSF/serum quotient (QAlb). C1q was assayed in samples of CSF and serum by ELISA. Albumin, immunoglobulin‐CSF/serum quotients, oligoclonal IgG and cell count were used to characterize the control groups. Group comprised 20 patients without inflammatory diseases but with increased QAlb. C1q concentration in CSF was at least five‐fold higher than expected for a molecular‐size‐dependent passage from blood. In a QC1q/QAlb quotient diagram 7/20 cases showed an intrathecal fraction in some cases over 80% of total CSF C1q concentration. The absolute C1q concentration in CSF increases with increasing Q Alb. C1q is possible to be intrathecally synthetized in patients with blood brain barrier dysfunctionThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.