2022
DOI: 10.7717/peerj.13908
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C1orf74 positively regulates the EGFR/AKT/mTORC1 signaling in lung adenocarcinoma cells

Abstract: Background Lung adenocarcinoma (LUAD) is a major type of lung cancer with poor prognosis and low 5-year survival rate, which urgently needs further investigation in order to elucidate its mechanisms completely and discover novel therapeutic targets. C1orf74 is a novel protein with unknown function either in normal cells or cancer cells. The aim of this study is to investigate the expression and function of C1orf74 in LUAD cells. Methods The expression of C1orf74 in LUAD was analyzed using the LUAD datasets f… Show more

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Cited by 4 publications
(7 citation statements)
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“…This enrichment of the pattern of the PI3K-Akt pathway positively correlated with C1orf74 expression in cervical cancer. Our findings are in agreement with the previous report of C1orf74 in lung adenocarcinoma, which is not hormonally regulated like cervical cancer, but showed a correlation of C1orf74 with the regulation of the EGFR/AKT/mTORC1 pathway [25]. The PI3K/Akt signaling pathway plays a crucial role in the Ras-mediated transformation of cancer cells [43].…”
Section: Discussionsupporting
confidence: 93%
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“…This enrichment of the pattern of the PI3K-Akt pathway positively correlated with C1orf74 expression in cervical cancer. Our findings are in agreement with the previous report of C1orf74 in lung adenocarcinoma, which is not hormonally regulated like cervical cancer, but showed a correlation of C1orf74 with the regulation of the EGFR/AKT/mTORC1 pathway [25]. The PI3K/Akt signaling pathway plays a crucial role in the Ras-mediated transformation of cancer cells [43].…”
Section: Discussionsupporting
confidence: 93%
“…C1orf74 emerged as a promising biomarker during this analysis, with higher expression of C1orf74 being associated with low overall survival. An extensive literature search identified only one publication suggesting a role for C1orf74 in regulating EGFR/AKT/mTORC1 signaling lung adenocarcinoma cells [25].…”
Section: Discussionmentioning
confidence: 99%
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