C18 : 1, C18 : 2 and C18 : 3trans andcis fatty acid isomers including conjugatedcisδ9,transδ11 linoleic acid (CLA) as well as total fat composition of German human milk lipids

Precht, D.; Molkentin, Joachim

doi:10.1002/(sici)1521-3803(19990801)43:4<233::aid-food233>3.0.co;2-b

Cited by 91 publications

(7 citation statements)

References 39 publications

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“…Acetate, butyrate, and formate have been found in HM of women worldwide (20)(21)(22)(23)(24)(25)(26) (20)(21)(22). We also confirm the positive correlations of HM acetate with butyrate and formate reported by Prentice et al The failure by us and others to detect propionate in HM is curious.…”

Section: Discussionsupporting

confidence: 88%

“…All three of these SCFAs were identified by nuclear magnetic resonance (NMR) at 1-2 months postpartum in a larger study of women (22). Butyrate has also been documented in studies of HM fat or fatty acids (23,24). Meng et al reported the presence of acetate and butyrate in HM from women with and without irritable bowel disease, finding higher acetate levels in women treated with aminosalicylates (25).…”

Section: Introductionmentioning

confidence: 94%

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Human Milk From Atopic Mothers Has Lower Levels of Short Chain Fatty Acids

et al. 2020

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Short chain fatty acids (SFCAs) are microbial metabolites produced in the gut upon fermentation of dietary fiber. These metabolites interact with the host immune system and can elicit epigenetic effects. There is evidence to suggest that SCFAs may play a role in the developmental programming of immune disorders and obesity, though evidence in humans remains sparse. Here we have quantified human milk (HM) SCFA levels in an international cohort of atopic and non-atopic mothers (n = 109). Our results demonstrate that human milk contains detectable levels of the SCFAs acetate, butyrate, and formate. Samples from atopic mothers had significantly lower concentrations of acetate and butyrate than those of non-atopic mothers. HM SCFA levels in atopic and non-atopic women also varied based on maternal country of residence (Australia, Japan, Norway, South Africa, USA). Reduced exposure to HM SCFA in early life may program atopy or overweight risk in breastfed infants.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 94%

Human Milk From Atopic Mothers Has Lower Levels of Short Chain Fatty Acids

et al. 2020

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“…Apparently, most of the FA18:1 CC bonds present in the human intestinal tissue was located at Δ9, while low abundance isomers with CC located at Δ11 and Δ12 were also found. A previous study has confirmed that FA18:1 Δ9 and Δ11 isomers were detected in human brain, and the existence of FA and TAG CC isomers, including C18:1 Δ9, Δ11, and Δ12 in human milk, was also reported . From the information on CID experiment, we can deduce that TAG52:2 contained fatty acid chains of FA16:0, FA18:1(Δ9), FA18:1(Δ11), and FA18:1(Δ12), and it was the possible mixture of TAG16:0_18:1(Δ9)_18:1(Δ9), TAG16:0_18:1(Δ11)_18:1(Δ11), TAG16:0_18:1(Δ12)_18:1(Δ12), TAG16:0_18:1(Δ9)_18:1(Δ11), TAG16:0_18:1(Δ9)_18:1(Δ12), and TAG16:0_18:1(Δ11)_18:1(Δ12).…”

Section: Resultsmentioning

confidence: 52%

Coupling Paternò-Büchi Reaction with Surface-Coated Probe Nanoelectrospray Ionization Mass Spectrometry for In Vivo and Microscale Profiling of Lipid C═C Location Isomers in Complex Biological Tissues

et al. 2019

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Lipids are important structural components of biological systems, and lipid CC locations play important roles in their biophysical and biochemical properties. Rapid, in vivo, in situ, and microscale lipidomics investigation (including precise identification of lipid CC locations and isomers) of biological specimen has great potential for clinical diagnosis, biological studies, and biomarker discovery. Here we report a novel lipidomics methodology by coupling Paternò-Büchi (PB) reaction with surface-coated probe nanoelectrospray ionization mass spectrometry (SCP-nanoESI-MS) for in vivo, in situ, and microscale analysis of lipid species and CC location isomers in complex biological tissues. The proposed SCP-PB-nanoESI-MS method was performed by application of a biocompatible solid-phase microextraction (SPME) probe for in vivo, in situ, and microscale sampling and extraction of lipids from biological tissues, and then some spray solvent containing PB reagent was applied to desorb lipid species enriched on SPME probe within a nanospray tip. Subsequently, ultraviolet irradiation was employed to initiate PB reaction for unsaturated lipids within the nanospray tip. After that, a high voltage was applied on the SPME probe to induce nanoESI for MS analysis under ambient and open-air conditions, and collision-induced dissociation was performed to the PB reaction product ions for determination of lipid CC locations and isomers. By using our proposed SCP-BP-nanoESI-MS method, microscale investigation of lipid compositions and CC location isomers for lipid droplet of Perilla seed and human intestinal tissue were successfully achieved, and in vivo analysis of lipid species and CC locations for zebrafish was accomplished.

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“…Not only the physiologically important PUFAs, but TFAs can also change depending on the lactation stage ( Table 3 ). The total TFA values in the literature range from 0.19 [mean w/w% ( 92 )] to 3.81 [mean w/w% ( 95 )] in C, with the lowest value in mothers with a traditional Chinese diet and highest value in German mothers with Western-type diet. Previous studies have reported varying results regarding the levels of TFAs in HM during lactation.…”

Section: Trans Isomeric Fatty Acids In Human Milkmentioning

confidence: 99%

“…There is a significant direct association between the proportion of TFAs in HM and their presence in plasma TGs and PLs of breast-fed infants ( 9 ). In this regard, the TFA content in HM should be reduced by modifying the diet of breastfeeding mothers, as dietary FAs are the major determinant of the composition of lipids in HM under sufficient energy supply ( 95 ). Since the largest part of the total TFA content of HM is EA, the total TFA content is closely related to its iTFA content.…”

Section: Relationship Between Human Milk Tfa Content and Infant Healthmentioning

confidence: 99%

Trans isomeric fatty acids in human milk and their role in infant health and development

Hatem,

Kaçar,

Kaçar

et al. 2024

Front. Nutr.

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It is well known that long chain polyunsaturated fatty acids (LCPUFAs) play an important role in neurodevelopment in the perinatal life. The most important source of these fatty acids is the diet, however, they can also be formed in the human body from their shorter chain precursors, the essential fatty acids. Since the WHO recommends exclusive breastfeeding for the first six months after birth, the exclusive source of these fatty acids for breastfed infants is human milk, which can be influenced by the mother’s diet. Unsaturated fatty acids can have either cis or trans configuration double bond in their chain with distinct physiological effects. Cis isomeric unsaturated fatty acids have several beneficial effects, while trans isomers are mostly detrimental, because of their similar structure to saturated fatty acids. Trans fatty acids (TFAs) can be further subdivided into industrial (iTFA) and ruminant-derived trans fatty acids (rTFA). However, the physiological effects of these two TFA subgroups may differ. In adults, dietary intake of iTFA has been linked to atherosclerosis, insulin resistance, obesity, chronic inflammation, and increased development of certain cancers, among other diseases. However, iTFAs can have a negative impact on health not only in adulthood but in childhood too. Results from previous studies have shown that iTFAs have a significant negative effect on LCPUFA levels in the blood of newborns and infants. In addition, iTFAs can affect the growth and development of infants, and animal studies suggest that they might even have lasting negative effects later in life. Since the only source of TFAs in the human body is the diet, the TFA content of breast milk may determine the TFA supply of breastfed infants and thus affect the levels of LCPUFAs important for neurodevelopment and the health of infants. In this review, we aim to provide an overview of the TFA content in human milk available in the literature and their potential effects on infant health and development.

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C18 : 1, C18 : 2 and C18 : 3trans andcis fatty acid isomers including conjugatedcisδ9,transδ11 linoleic acid (CLA) as well as total fat composition of German human milk lipids

Cited by 91 publications

References 39 publications

Human Milk From Atopic Mothers Has Lower Levels of Short Chain Fatty Acids

Human Milk From Atopic Mothers Has Lower Levels of Short Chain Fatty Acids

Coupling Paternò-Büchi Reaction with Surface-Coated Probe Nanoelectrospray Ionization Mass Spectrometry for In Vivo and Microscale Profiling of Lipid C═C Location Isomers in Complex Biological Tissues

Trans isomeric fatty acids in human milk and their role in infant health and development

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