C-terminal binding protein 2 promotes high-glucose-triggered cell proliferation, angiogenesis and cellular adhesion of human retinal endothelial cell line

Li, Han; Zhou, Feng; Cao, Xingjian; Zhao, Ping; Huang, Xiaobo; Xie, W.; Zhang, Guowei; Chen, Xiang

doi:10.1007/s10792-022-02283-9

Cited by 2 publications

(1 citation statement)

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“…In addition to being associated with normal cell carcinogenesis, CtBP2 has also been implicated in embryonic development, adipogenesis, and angiogenesis [ 38 , 40 ]. For example, Li et al showed that CtBP2 promotes high glucose-induced cell proliferation, angiogenesis, and cell adhesion through the Akt signaling pathway, and that CtBP2 may be a potential target for diabetic retinopathy (DR) prevention [ 41 ]. Wang et al used Co-IP to show that CtBP2 interacts with receptor-interacting protein 140 (RIP140).…”

Section: Overview Of Ctbpmentioning

confidence: 99%

C-Terminal Binding Protein: Regulator between Viral Infection and Tumorigenesis

Huang,

Li,

et al. 2024

Viruses

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C-terminal binding protein (CtBP), a transcriptional co-repressor, significantly influences cellular signaling, impacting various biological processes including cell proliferation, differentiation, apoptosis, and immune responses. The CtBP family comprises two highly conserved proteins, CtBP1 and CtBP2, which have been shown to play critical roles in both tumorigenesis and the regulation of viral infections. Elevated CtBP expression is noted in various tumor tissues, promoting tumorigenesis, invasiveness, and metastasis through multiple pathways. Additionally, CtBP’s role in viral infections varies, exhibiting differing or even opposing effects depending on the virus. This review synthesizes the advances in CtBP’s function research in viral infections and virus-associated tumorigenesis, offering new insights into potential antiviral and anticancer strategies.

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Section: Overview Of Ctbpmentioning

confidence: 99%