C ₃ ‐Symmetric Ligands for Catalysis

Controlling dynamic stereoisomerism in transition-metal folded baskets

“…[5][6][7][8][9][10][11] Hence, placing an electrophilic metal in a chiral/dynamic environment affords a greater discrimination of substrates 12 and is essential for developing chiral discrimination technologies [17][18][19][20] and expanding the scope of stereoselective synthesis. [21][22][23][24] In particular, transition-metal complexes of multidentate nitrogen-containing ligands (i.e. tris(pyridylmethyl)amine (TPA), Fig.…”

Expanding the Diversity of Polycyclic Aromatics Through a Suzuki–Miyaura Cross‐Coupling Strategy

“…Chiral C 3 -symmetric molecules have been identified as helpful ligands known to induce high degrees of stereocontrol in various transition metal-catalyzed asymmetric transformations in which nonchelating or unfunctionalized substrates are involved. [13] We therefore sought a general and simple methodology [14] for their synthesis, based on the utilization of acidcatalyzed trimerizations of carbonyl compounds followed by SM reactions. To this end, 1,3,5-tris(4-iodophenyl)benzene (1, Scheme 1) was prepared from 4-iodoacetophenone in a SiCl 4 -mediated trimerization reaction based on classical cyclocondensation chemistry.…”