C-SPECT—A Clinical Cardiac SPECT/Tct Platform: Design Concepts and Performance Potential

Chang, Wei; Ordoñez, C.E.; Liang, Haoning; Li, Yusheng; Liu, Jingai

doi:10.1109/tns.2009.2028138

Cited by 40 publications

(15 citation statements)

References 49 publications

(37 reference statements)

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“…GE Healthcare (Haifa, Israel) has announced the development of a new dedicated cardiac SPECT system (figure 3(b)) (Volokh et al 2008, Garcia et al 2008, Esteves et al 2008, Buechel et al 2010). Another dedicated cardiac SPECT system called C-SPECT, being built at Rush University Medical Center, Chicago, IL, is being funded by the NIH (Chang et al 2008, Ordonez et al 2008). Ultimately, dedicated cardiac SPECT systems with total acquisition times of 2–3 min may become available.…”

Section: Introductionmentioning

confidence: 99%

Dynamic single photon emission computed tomography—basic principles and cardiac applications

et al. 2010

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The very nature of nuclear medicine, the visual representation of injected radiopharmaceuticals, implies imaging of dynamic processes such as the uptake and wash-out of radiotracers from body organs. For years, nuclear medicine has been touted as the modality of choice for evaluating function in health and disease. This evaluation is greatly enhanced using single photon emission computed tomography (SPECT), which permits three-dimensional (3D) visualization of tracer distributions in the body. However, to fully realize the potential of the technique requires the imaging of in vivo dynamic processes of flow and metabolism. Tissue motion and deformation must also be addressed. Absolute quantification of these dynamic processes in the body has the potential to improve diagnosis. This paper presents a review of advancements toward the realization of the potential of dynamic SPECT imaging and a brief history of the development of the instrumentation. A major portion of the paper is devoted to the review of special data processing methods that have been developed for extracting kinetics from dynamic cardiac SPECT data acquired using rotating detector heads that move as radiopharmaceuticals exchange between biological compartments. Recent developments in multi-resolution spatiotemporal methods enable one to estimate kinetic parameters of compartment models of dynamic processes using data acquired from a single camera head with slow gantry rotation. The estimation of kinetic parameters directly from projection measurements improves bias and variance over the conventional method of first reconstructing 3D dynamic images, generating time–activity curves from selected regions of interest and then estimating the kinetic parameters from the generated time–activity curves. Although the potential applications of SPECT for imaging dynamic processes have not been fully realized in the clinic, it is hoped that this review illuminates the potential of SPECT for dynamic imaging, especially in light of new developments that enable measurement of dynamic processes directly from projection measurements.

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Section: Introductionmentioning

confidence: 99%

Dynamic single photon emission computed tomography—basic principles and cardiac applications

et al. 2010

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“…C-SPECT [1] is a proposed compact cardiac SPECT platform that offers adaptive imaging through multiple collimator configurations. It consists of a stationary system of pixelated detectors and a slit-slat collimator with interchanging lead slits and collapsible tungsten slats.…”

Section: The C-spect Projectmentioning

confidence: 99%

C-SPECT, a novel cardiac single-photon emission computed tomography system

Strologas¹,

Rozler²,

Metzler³

et al. 2017

Proceedings of 38th International Conference on High Energy Physics — PoS(ICHEP2016)

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Single-photon emission computed tomography (SPECT) is the leading medical-imaging method for the study myocardial perfusion, which is important for the diagnosis and treatment of coronary-artery disease, the number-one killer in the western world. C-SPECT is a proposed dedicated cardiac SPECT system designed to achieve at least double the geometric efficiency compared to general-purpose dual-head gamma cameras, for the same resolution. This improvement can be used to reduce patient radiation dose, achieve fast or dynamic imaging, and enhance the quality of images. The system consists of stationary detector modules of pixelated NaI(Tl), a slit-slat collimator with interchangeable slits and collapsible slats, and an integrated CT for attenuation correction. The collimator slits provide pinhole collimation in the transverse plane, whereas the slats offer parallel-beam collimation in the axial direction. The adaptive power of the collimator allows us to adjust, in situ, the sensitivity and resolution depending on the imaging task. This way, superior reconstructed-image resolution could be achieved if the system operates with the usual geometric efficiency of the industry's benchmark. The system gantry wraps around patients' left-front thorax and provides a transverse projection minification of ∼ 50%, for a maximal number of minimally-overlapping projections, given the limitations from the spatial resolution of the pixelated detector. We present the design principles and preliminary imaging performance using three-dimensional iterative reconstruction with resolution recovery and data from the newly-built laboratory prototype as well as Monte-Carlo (MC) simulations of the full system.

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“…This is the case for C-SPECT [2], a dedicated cardiac SPECT platform, the design concepts of which are shown in Fig. l body-contouring detector.…”

Section: Introductionmentioning

confidence: 99%

A cost-effective high-resolution modular pixelated clinical SPECT detector based on small NaI (Tl) pixels with medium-size single-anode PMTs, utilizing spatial modulation of scintillation light output

Rozler

Chang

2012

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)

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The current trend toward SPECT systems dedi cated to imaging specific organs has created new pressures to improve gamma camera performance. A number of designs rely on projection minification to increase system sensitivity by acquiring multiple non-overlapping simultaneous views, placing stringent requirements on detector intrinsic spatial resolution (ISR). Curved detector geometries require modular assemblies, making monolithic slab detectors impractical due to their large dead areas at the edges. Previously, we described a modular detector based on a scintillator block comprised of 2.75 x2.75 x 10 mm 3 NaI(Tl) pixels in a 3 x 3 mm pitch and decoded by an array of 51 mm diameter single-anode PMTs. The event positioning accuracy of the curved detector, averaged over its entire area, exceeds that of a hypothetical monolithic slab detector with 2.75 mm ISR. To reduce the pixel size/pitch and thus increase linear sampling in the transaxial dimension (the dimension along which the detector is curved and minification is applied), we introduce scintillation light output modulation between neighboring pixels. A series of narrow absorbing stripes is applied at the exit surface of every other pixel column, producing a modulation in light output between adjacent pixels and allowing the use of energy discrimination to more effectively assign events to the correct pixel. Compared to the 3x3 mm pitch modules, our new detector, with 2.25 x2.75 x 10 mm 3 NaI(Tl) pixels (2.5 x 3 mm pitch), achieves the same event positioning performance in terms of the average event positioning error, while yielding 10.3% energy resolution. This translates to an improvement in linear sampling, without any loss in positioning accuracy (and, thus, effective spatial resolution), a modest energy resolution degradation. accomplished without a cost increase.

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C-SPECT—A Clinical Cardiac SPECT/Tct Platform: Design Concepts and Performance Potential

Cited by 40 publications

References 49 publications

Dynamic single photon emission computed tomography—basic principles and cardiac applications

Dynamic single photon emission computed tomography—basic principles and cardiac applications

C-SPECT, a novel cardiac single-photon emission computed tomography system

A cost-effective high-resolution modular pixelated clinical SPECT detector based on small NaI (Tl) pixels with medium-size single-anode PMTs, utilizing spatial modulation of scintillation light output

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