C. sinensis ablates allograft vasculopathy when used as an adjuvant therapy with cyclosporin A

Jordan, J.L.; Hirsch, Gregory M.; Lee, T.D.G.

doi:10.1016/j.trim.2008.05.010

Cited by 24 publications

(13 citation statements)

References 39 publications

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“…According to Chinese tradition and the Chinese Pharmacopoeia, C. sinensis can ''tonify the lung, replenish the kidneys, arrest bleeding, dissolve phlegm, treat chronic coughs, treat spontaneous sweating and restore strength after an illness'' (Zhu et al, 1998a(Zhu et al, , 1998b. More recent studies suggest that Cordyceps may have immunomodulatory (Jordan et al, 2008), pro-apoptotic (Zhang and Wu, 2007), anti-proliferative (Yang et al, 2003) and anti-fibrotic effects (Li et al, 2006;Wang et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of TGF-β1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats

Pan

Zhang

et al. 2013

Food and Chemical Toxicology

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Section: Introductionmentioning

confidence: 99%

Inhibition of TGF-β1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats

Pan

Zhang

et al. 2013

Food and Chemical Toxicology

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“…One study showed that a dried powder preparation of mycelia of CS called Corbrin capsule prevented rejection of renal transplants and protected renal function [22]. Other studies demonstrated that CS could prolong graft survival in a rat heterotopic allograft transplant model [3,8].…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have shown that CS has immunoregulatory activity [1][2][3][4][5]. Recently, Jordan and colleagues demonstrated that oral delivery of the extract of CS, together with Cyclosporine induced cardiac tolerance [8], but the underlying mechanism is unknown.…”

Section: Introductionmentioning

confidence: 99%

Immunoregulatory Cordyceps sinensis increases regulatory T cells to Th17 cell ratio and delays diabetes in NOD mice

Shi¹,

Wang²,

Jin³

et al. 2009

International Immunopharmacology

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“…T cells than groups C and D mice; it might be possible that cultured mycelia from C. sinensis could increase the activity of CD8 ? regulatory/ suppressor T cells [22].…”

Section: Discussionmentioning

confidence: 99%

Immunological alterations in lupus-prone autoimmune (NZB/NZW) F1 mice by mycelia Chinese medicinal fungus Cordyceps sinensis-induced redistributions of peripheral mononuclear T lymphocytes

Chen

Yang

et al. 2009

Clin Exp Med

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Mycelia products from wild-form Cordyceps sinensis could be constantly produced in a large scale and would be a better source of this herbal medicine. Our purpose was to investigate the immunological effects of an orally administered hot-water extract cultured mycelium of C. sinensis in lupus-prone (NZB/NZW) F1 hybrids. Forty female mice were divided into four groups and were given 2.4 mg/g/day oral doses of C. sinensis starting at three (group A), six (group B), or eight (group C) months of age, whereas the remaining group (group D) served as a control. Survival, proteinuria, and titers of anti-double-stranded DNA autoantibodies were evaluated. Treatment with C. sinensis resulted in increased survival, decreased proteinuria, and reduced titers of anti-double-stranded DNA antibody in groups A and B. Moreover, the mice in groups A and B showed significantly reduced percentages of CD4(+) T cells (*P < 0.05) and increased percentages of CD8(+) T cells in peripheral blood mononuclear cells (PBMC) after C. sinensis administration. At 6 months of age, the proliferation rate of BrdU-incorporated spleen cells was significantly decreased after 48 and 72 h of C. sinensis treatment (**P < 0.01) in group A of mice. In conclusions, early medication with C. sinensis induced the redistribution of PBMC and attenuated the disease severity of lupus in (NZB/NZW) F1 mice.

show abstract

C. sinensis ablates allograft vasculopathy when used as an adjuvant therapy with cyclosporin A

Cited by 24 publications

References 39 publications

Inhibition of TGF-β1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats

Inhibition of TGF-β1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats

Immunoregulatory Cordyceps sinensis increases regulatory T cells to Th17 cell ratio and delays diabetes in NOD mice

Immunological alterations in lupus-prone autoimmune (NZB/NZW) F1 mice by mycelia Chinese medicinal fungus Cordyceps sinensis-induced redistributions of peripheral mononuclear T lymphocytes

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