C<scp>ase</scp> R<scp>eport</scp>: Fibrolamellar hepatocellular carcinoma in a Japanese woman: A case report and review of Japanese cases

Hoshino, Hiroshi; Katada, Naoyuki; Nishimura, Daisaku; Imada, Junko; Morita, Kiyoshi; Yoshida, Norio; Sano, Hiroshi; Okamoto, Katsushi; Kato, Katsumoto

doi:10.1111/j.1440-1746.1996.tb01701.x

Cited by 15 publications

(2 citation statements)

References 14 publications

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“…Based on the SEER database, there appears to be a racial/ethnic predilection for Caucasians [47]. However, FLC has been reported from a wide variety of geographical locations including Mexico [53], Saudi Arabia [33], South Africa [54, 55], Japan [56], Taiwan [57, 58], Mainland China [59], Republic of Korea [60], Thailand [32], India [28, 61], and Europe [62], and the extent of the racial/ethnic bias remains poorly defined.…”

Section: Clinical Findingsmentioning

confidence: 99%

Fibrolamellar Carcinoma: 2012 Update

Torbenson

2012

Scientifica

146

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Fibrolamellar carcinomas are a unique type of primary liver cancer. They occur most commonly in children and young adults. Their etiology remains a mystery, as they are not associated with chronic liver disease. Fibrolamellar carcinomas are not indolent tumors, but have an overall better prognosis than typical hepatocellular carcinomas, in part because of the younger age at presentation and the lack of cirrhosis. The most important prognostic feature is whether the tumor is resectable. Histologically, the tumor is made up of large cells that contain abundant mitochondria. The nuclei of the tumor cells have prominent nucleoli. The tumor cells induce the formation of extensive intratumoral fibrosis, which often grows in parallel, or lamellar bands. The tumor cells clearly show hepatocellular features but are also unique in showing both biliary and neuroendocrine differentiation. The uniqueness of fibrolamellar carcinoma extends to their molecular findings. While the genetic abnormalities that lead to fibrolamellar carcinomas are not yet known, studies have shown that they lack mutations in the genes most commonly mutated in typical hepatocellular carcinoma (TP53 and CTNNB1). In this paper, the clinical, pathological, and basic science literature on fibrolamellar carcinoma is comprehensively reviewed. Key areas of needed research are also discussed.

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Section: Clinical Findingsmentioning

confidence: 99%

Fibrolamellar Carcinoma: 2012 Update

Torbenson

2012

Scientifica

146

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“…FL-HCC is very rare in Oriental countries [9]. According to the 16th survey of the Liver Cancer Study Group of Japan in 2004, the incidence of FL-HCC in Japan is 0.1% (6/6795) [10].…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular carcinoma with a central scar and a scalloped tumor margin resembling focal nodular hyperplasia in macroscopic appearance

et al. 2006

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Clinical evaluation of serum alpha‐fetoprotein–IgM immune complexes on the diagnosis of primary hepatocellular carcinoma

Jiang

et al. 2009

Clinical Laboratory Analysis

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We evaluated clinical significance of serum alpha-fetoprotein (AFP)-IgM immune complexes, in comparison with free AFP, on the diagnosis of primary hepatocellular carcinoma (HCC). Serum levels of AFP-IgM immune complexes and free AFP were determined by the ELISA method and electrochemiluminescence, respectively, in 103 healthy controls, 74 patients suffering from primary HCC, 27 patients suffering from liver cirrhosis, and 63 patients suffering from chronic hepatitis. The best cut-off value of AFP-IgM and free AFP for diagnosis of primary HCC were 300 AU/mL and 10 microg/L respectively, according to the area under the curve (AUC) in this study. The sensitivity of AFP-IgM and free AFP were 64.9 and 79.7%, and the specificity were 75.6 and 80.3%, respectively, when all cases of primary HCC were analyzed, and the AUC of free AFP was larger than that of AFP-IgM (0.85 vs. 0.72, Z=3.21). However, in case of primary HCC at early stages (stages I and II) were analyzed, the AUC of AFP-IgM was larger than that of free AFP (0.91 vs. 0.82, Z=1.73), which demonstrated that the sensitivity of AFP-IgM and free AFP were 94.4 and 72.2%, and the specificity were 81.9 and 79.9%, respectively. When both AFP-IgM and free AFP were positive, the specificity of diagnosis of primary HCC was 89.1%, and the efficacy was 79.0%. It is concluded that either sensitivity or specificity of serum level of AFP-IgM immune complexes was higher than that of free AFP in the diagnosis of primary HCC at early stages. As there was false positive AFP-IgM existed in the patients suffering from cirrhosis and chronic hepatitis, the combination of free AFP and AFP-IgM could significantly increase specificity and decrease false negative and/or false positive in the primary HCC at early stages.

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Case Report: Fibrolamellar hepatocellular carcinoma in a Japanese woman: A case report and review of Japanese cases

Cited by 15 publications

References 14 publications

Fibrolamellar Carcinoma: 2012 Update

Fibrolamellar Carcinoma: 2012 Update

Hepatocellular carcinoma with a central scar and a scalloped tumor margin resembling focal nodular hyperplasia in macroscopic appearance

Clinical evaluation of serum alpha‐fetoprotein–IgM immune complexes on the diagnosis of primary hepatocellular carcinoma

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