C<scp>ASE</scp> R<scp>EPORT</scp>: A case of lymphoepithelioma‐like carcinoma of the oesophagus and review of the literature

Sashiyama, Hiroshi; Nozawa, Akio; Kimura, Masayuki; Nomura, Eiichi; Tamaru, Jun‐ichi; Ninomiya, Eiichiro; Koide, Yuji; Iino, Masatoshi; Ozawa, K

doi:10.1046/j.1440-1746.1999.01911.x

Cited by 30 publications

(21 citation statements)

References 14 publications

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“…To our knowledge, only 19 cases of the esophageal squamous cell carcinoma with lymphoid stroma have been reported, and interestingly, most of these cases occurred in Japanese patients. In these previous studies, the clinical features, such as age distribution, sex ratio and location of the lesion, showed no significant differences between esophageal carcinoma with lymphoid stroma and common esophageal cancers 11,13,14) . Thus, we speculate that squamous cell carcinoma with lymphoid stroma might be associated with etiological factors 16) .…”

Section: Discussionmentioning

confidence: 85%

“…Lymphocytic infiltration is thought to represent a host immune reaction against tumor cells, and its prognostic significance has been well documented in human cancers [9][10][11] . Herein, we present a rare case of esophageal squamous cell carcinoma with lymphoid stroma, and describe its endoscopic, histological, and immunohistochemical characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Esophageal Squamous Cell Carcinoma with Lymphoid Stroma: Histopathological and Immunohistochemical Analysis

Chino

Makuuchi

Ozawa

et al. 2014

Ann. Cancer Res. Therap.

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Prominent lymphocytic infiltration and lymphoid follicles surrounding tumor cells are extremely rare findings in esophageal carcinoma. We report on the endoscopic, histological, and immunohistochemical features of a rare case of squamous cell carcinoma of the esophagus with lymphoid stroma. A 59-year-old woman was diagnosed with type 0-Is superficial esophageal carcinoma and underwent radical esophagectomy with lymph node dissection. Macroscopically, the tumor was protruding, and was covered with normal epithelium resembling a submucosal tumor. Histopathological examination demonstrated that the esophageal lesion was classified as a poorly differentiated squamous cell carcinoma with lymphoid stroma, extending to the deep submucosa (SM3) with lymph node metastasis (T1b, N2, M0, stage II). Epstein-Barr virus infection was ruled out by immunohistochemical and in situ hybridization analyses. Infiltrating B-lymphocytes were observed forming lymphoid follicles adjacent to carcinoma cell nests, and numerous T lymphocytes were widely spread throughout the specimen, as well as distributed in the marginal zone of the lymphoid follicles. Prominent human leukocyte antigen DR region (HLA-DR) immunoreactivity was noted in most carcinoma cells and focally infiltrating B cells in the lymphoid follicles, and these observations were thought to be due to activation of immunological interactions between carcinoma cells positive for HLA-DR and host lymphocytes.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Esophageal Squamous Cell Carcinoma with Lymphoid Stroma: Histopathological and Immunohistochemical Analysis

Chino

Makuuchi

Ozawa

et al. 2014

Ann. Cancer Res. Therap.

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“…To our knowledge, only 29 cases have been reported in the literature, including the present case. [6][7][8][9][10][11][12][13][14]22 The epidemiology of LELC is somewhat similar to squamous cell carcinoma (SCC) of the esophagus. 1,23 Both neoplasms are more prevalent in China and Southeast Asia and share associated risk factors such as alcohol and tobacco use.…”

Section: Discussionmentioning

confidence: 99%

“…5 However, rare cases of LELC of the esophagus, most of them from Southeast Asian or Western European countries, have been reported in the literature. [6][7][8][9][10][11][12][13][14] Here we report, to our knowledge, the first primary LELC of the esophagus associated with EBV infection in a patient from Chile, a Latin American fairly homogeneous Hispanic country. 15 The clinicopathologic features of this case together with molecular findings, such as lack of EBER-1 expression, the gold standard for EBV detection in histopathologic lesions, 16 and the presence of the type ''i''/XhoI loss novel recombinant EBV strain 17 prompted us to report this case.…”

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confidence: 99%

Epstein-Barr Virus-associated Primary Lymphoepitheliomalike Carcinoma of the Esophagus

Valbuena

Retamal²,

Bernal³

et al. 2007

Diagnostic Molecular Pathology

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Primary lymphoepitheliomalike carcinomas (LELC) of the esophagus are uncommon, with only 29 previously reported cases in the literature. Primary LELC of the esophagus is associated with Epstein-Barr virus (EBV). We herein report a 52-year-old man who presented with dysphagia and weight loss and was found to have a polypoid mass in the middle esophagus. Pathologic examination showed LELC. EBV infection was demonstrated by immunohistochemical detection of EBNA-1 in neoplastic cells and polymerase chain reaction amplification for EBNA-3C, BamHI-F, and W1/I1 regions but not by in situ hybridization by EBER-1 transcripts. EBV genotyping analysis demonstrated infection by a novel type "i"/XhoI loss recombinant strain. Although it is accepted that polymorphisms at BamHI-W1/I1 region cosegregate with polymorphisms at XhoI restriction site, this novel recombinant EBV has been identified in healthy donors and in nasal NK/T-cell lymphoma. To our knowledge, this is the first report that describes this recombinant type "i"/XhoI loss EBV strain in a primary LELC of the esophagus.

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“…LELC has been usually detected in organs like the thymic gland [1], breast [2], stomach [3], salivary gland [4] and lungs [5]. But, tumors of the esophagus other than squamous cell carci noma and adenocarcinoma are quite rare [6]. The prognosis of patients suffering from this type of cancer has been reported to be favorable [7].…”

Section: Introductionmentioning

confidence: 99%

A case study of rare lympho-epithelioma like esophageal carcinoma

Mukherjee¹,

Nath²,

Sinha³

et al. 2017

Cancer Rep Rev

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Sub classification of esophageal carcinoma is important due to differences in prognosis and management. Esophageal Lymphoepithelioma-Like Carcinoma (LELC) is extremely rare, with only a few cases reported to date. Carcinoma with lymphoid infiltration in the stomach, breast or nasopharynx has a good prognosis, but in the esophagus this histological type is extremely rare and its characterization is unclear.Review of the literature revealed case reports describing lesions with similar histology. We present a 69-year-old man with a giant pedunculated-polypoid lesion of the esophagus shrinking the lumen. Endoscopic excision of the tumor was performed and final histopathological diagnosis was confirmed to be LELC.

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CASE REPORT: A case of lymphoepithelioma‐like carcinoma of the oesophagus and review of the literature

Cited by 30 publications

References 14 publications

Esophageal Squamous Cell Carcinoma with Lymphoid Stroma: Histopathological and Immunohistochemical Analysis

Esophageal Squamous Cell Carcinoma with Lymphoid Stroma: Histopathological and Immunohistochemical Analysis

Epstein-Barr Virus-associated Primary Lymphoepitheliomalike Carcinoma of the Esophagus

A case study of rare lympho-epithelioma like esophageal carcinoma

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