C-reactive protein-to-albumin ratio and six-month mortality in incident hemodialysis patients

Sant'ana, Mariana; Gameiro, Joana; Costa, Cláudia; Branco, Carolina; Silva, Bernardo Marques da; Peres, Nadiesda; Cardoso, Ana; Abrantes, Ana Mafalda; Fonseca, José Agapito; Outerelo, Cristina; Resina, Cristina; Lopes, José António

doi:10.1080/0886022x.2023.2182615

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…A large nationwide study has shown that serum albumin predicts all-cause, cardiovascular, and infection-related mortality in both PD and HD patients [21]. A recent study involving 787 hemodialysis patients has demonstrated that higher CAR was signi cantly associated with a higher mortality risk in the rst six months of HD [9]. Our study also identi ed that CAR were independent prognostic biomarkers in hemodialysis patients.…”

Section: Discussionsupporting

confidence: 64%

“…Among these factors, markers of the systemic in ammatory response, such as the platelet-to-lymphocyte ratio (PLR) [4], lymphocyte-to-CRP ratio (LCR) [5], systemic immune-in ammation index (SII) [6], and neutrophil-to-lymphocyte ratio (NLR) [7], have emerged as key players in the progression and prognosis of hemodialysis patients. Furthermore, nutrition-related indicators, including the CRP-to-albumin ratio (CAR) and prognostic nutritional index (PNI) [8][9][10][11], have demonstrated their prognostic value in predicting outcomes for individuals undergoing hemodialysis. Notably, these indicators possess several advantages, such as simplicity, costeffectiveness, widespread availability in most dialysis laboratories, and their con rmed value in predicting the survival of hemodialysis patients.…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Indices for Overall Survival in Hemodialysis Patients: A multicenter cohort study

Chen,

Wang,

Yin

et al. 2024

Preprint

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Objective This study aimed to determine the best inflammation and nutrition-related indicator for overall survival prediction in patients undergoing hemodialysis from 138 dialysis centers of Beijing. Methods This study included six indicators, for which optimal thresholds were calculated using an outcome-driven method. Kaplan-Meier estimator was utilized to evaluate OS, while multivariate Cox proportional hazard models and restricted cubic splines were employed to assess the relationship between these indicators and OS. C-index, receiver operating characteristic curves and decision curve analysis were used to evaluate the predictive ability of the different indicators. Results All indicators except for platelet-to-lymphocyte ratio were identified as independent predictors of OS. Among these indicators, the prognostic nutritional index (PNI) consistently demonstrated superior discriminatory ability in predicting outcomes among hemodialysis patients. The optimal cut-off value for PNI was determined to be 42.3. Each one-unit increase or standard deviation increase in PNI is associated with a 0.956-fold or 0.78-fold decrease in mortality risk. Conclusions PNI has demonstrated superior reliability as a prognostic indicator for hemodialysis patients compared to LCR, CAR, SII, PLR and NLR. The efficient assessment of PNI effectively identifies high-risk individuals and highlights its significance as a valuable prognostic tool in clinical settings.

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Inflammatory Indices for Overall Survival in Hemodialysis Patients: A multicenter cohort study

Chen,

Wang,

Yin

et al. 2024

Preprint

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Inflammatory indexes predict mortality in non-malignant patients in palliative care

Ceylan,

Akkurt,

Gurses

et al. 2024

Int J Palliat Nurs

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Background: The literature on the use of inflammatory indexes for palliative care patients without malignancy is scarce. Aims: To determine which inflammatory indexes are associated with the mortality risks of non-malignant patients hospitalised and receiving palliative care. Methods: Discharged or deceased patients in a palliative care unit of a secondary care hospital were included. The laboratory values were obtained during the first 48 hours of hospitalisation. Findings: As a result of univariate Cox regression analysis, 14-day mortality rate was affected by lymphocyte ratio, neutrophil-to-albumin ratio (NAR), C-reactive protein/albumin ratio (CAR), multi-inflammatory indexes (MII-1) and MII-2 (p<0.001, p=0.001, p=0.002, p=0.009 and p=0.003, respectively); NLR, CLR, NAR, CAR, MII-1 and MII-2 (respectively p=0.005, p<0.001, p<0.001, p<0.001, p=0.001 and p<0.001) affected 28-day mortality rate. Indexes that statistically significantly increased both 14-day and 28-day mortality rates independently of other variables were CLR, NAR, CAR, MII-1 and MII-2. Conclusion: High values in inflammatory indexes, including C-reactive protein and albumin increase the risk of 14-day and 28-day mortality rates in palliative care non-malignant patients.

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Prognostic significance of the hs-CRP/Alb ratio for cardiovascular events in patients with end-stage renal disease undergoing maintenance hemodialysis

Luo

2024

Am J Transl Res

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C-reactive protein-to-albumin ratio and six-month mortality in incident hemodialysis patients

Cited by 3 publications

References 34 publications

Inflammatory Indices for Overall Survival in Hemodialysis Patients: A multicenter cohort study

Inflammatory Indices for Overall Survival in Hemodialysis Patients: A multicenter cohort study

Inflammatory indexes predict mortality in non-malignant patients in palliative care

Prognostic significance of the hs-CRP/Alb ratio for cardiovascular events in patients with end-stage renal disease undergoing maintenance hemodialysis

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