C-reactive protein response to a vegan lifestyle intervention

Sutliffe, Jay T.; Wilson, Lori D.; Heer, Hendrik D. de; Foster, Ray L.; Carnot, Mary Jo

doi:10.1016/j.ctim.2014.11.001

Cited by 44 publications

(33 citation statements)

References 17 publications

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“…Recently, numerous research efforts have reported a beneficial effect of nutrients such as n-3 polyunsaturated fatty acids and flavonoids on inflammatory processes underlying cognitive dysfunctions [ 67 ]. Similar findings were reported for a brief lifestyle intervention, including a vegan diet rich in fresh fruits and vegetables, whole grains, and various legumes, nuts, and seeds, to reduce systemic inflammation as measured by circulating hsCRP [ 68 ].…”

Section: Discussionsupporting

confidence: 74%

C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders

et al. 2020

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Cognitive dysfunction is a prominent feature of psychiatric disorders. Studies have shown that systemic low-grade inflammation is crucial in the development of cognitive deficits across psychiatric disorders. The aim of this study was to further examine the role of inflammation and inflammatory mediators in cognitive function in psychiatric disorders. This study included 364 inpatients (53% females) with International Classification of Diseases (ICD)-10 F3 (affective disorders) and F4 (neurotic, stress-related, and somatoform disorders) diagnoses. The mean age was 52 years (22 to 69 years) and the median body mass index was 27.6. Cognitive function was assessed with the Color–Word Interference Test after Stroop and the Trail-Making Test A/B. Multiple linear regression models were calculated to assess the predictive value of C-reactive protein and the kynurenine/tryptophan ratio on cognitive function controlling for age, sex, education, premorbid verbal intelligence quotient illness duration, depressive symptoms, and obesity-related parameters (e.g., body mass index, high-density lipoprotein). Our data confirm that in patients with psychiatric disorders, C-reactive protein serum concentration is a relevant and important predictor of Trail-Making Test B performance, measuring cognitive flexibility. The effect size of this association did not change much after adding clinical and metabolic variables into the regression model. The kynurenine/tryptophan ratio was not related to cognitive test scores. The involvement of C-reactive protein as a peripheral inflammatory marker in cognitive flexibility and psychomotor processing speed in psychiatric illness can be concluded.

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Section: Discussionsupporting

confidence: 74%

C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders

et al. 2020

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“…Consumption of red (e.g., beef, pork, lamb) and processed meat is correlated with certain types of cancer, cardiovascular disease, and diabetes (Aston, Smith, & Powles, 2012;Gonzalez, 2006;Health Canada, 2019;Sutliffe, Wilson, de Heer, Foster, & Carnot, 2015;World Cancer Research Fund International, 2017). In addition, livestock production is responsible for 80% of agricultural greenhouse gas (GHG) emissions worldwide (McMichael et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Reducing meat consumption: Identifying group-specific inhibitors using latent profile analysis

Lacroix

Gifford

2019

Appetite

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Climate change mitigation requires changes in greenhouse gas emitting behaviours. This dissertation aims to provide insights into the influences of behaviour change for two high-impact pro-environmental behaviours: climate policy support and consumption of animal products. It does so by using quasi-and randomized experiments and by monitoring changes in behaviour over time. Study 1 examined changes in climate policy support and climate change risk perception over the course of a naturally occurring event: seasonal forest fires. It employed growth curve modeling techniques in a structural equation modeling framework to analyze longitudinal relations between these two constructs over time, and to examine growth in climate change risk perception while controlling for the effect of exposure to forest fires and other extreme weather. Indirect exposure to forest fires (e.g., media) had a modest effect on climate change risk perception. Climate change risk perception for individuals with above-mean perceptions of scientific agreement tended to increase faster than for those with below-mean perceptions. Individuals whose climate change risk perception grew at a faster-than-average rate tended to also grow at a faster-than-average rate for climate policy support. Study 2 provided insight into the psychological influences on consumption of animal products and on willingness to reduce. Following a comprehensive literature review, known influences were examined using Latent Profile Analysis to identify groups of individuals with similar perceptions of facilitators of meat consumption and obstacles to reducing it. Three groups were identified: stronghindrance meat eaters, moderate-hindrance meat eaters, and reducers. Validation variables confirmed the practicality of the three profiles: groups differed in their current consumption of animal products and in their willingness to reduce. Using these findings, three group-matched interventions were designed in Study 3. Intervention design was informed by four behaviour-iv change frameworks. Participants were randomly assigned to one of four conditions: control condition, implementation-intention condition, information-and-healthy-recipe condition, and information-and-substitution condition. Then, they completed up to 28 days of food diaries.Multilevel model analyses were employed to examine changes in the consumption of animal products over time. Participants reduced their consumption by 20 grams of CO2 per day on average. Individuals that were randomly assigned to an intervention condition that matched their meat-eater profile reduced their consumption of animal products by 40 grams CO2 per day on average. Taken together, these studies highlight the importance of considering individual differences (i.e., tailoring) when designing pro-environmental behaviour interventions. v

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“…Subjects with unusual dietary habits (e.g., vegetarians) were also excluded (Sutliffe et al, 2015). Hematological and biochemical tests needed to be within the normal range.…”

Section: Methodsmentioning

confidence: 99%

Memory Training Program Decreases the Circulating Level of Cortisol and Pro-inflammatory Cytokines in Healthy Older Adults

Pesce

Tatangelo

Fratta

et al. 2017

Front. Mol. Neurosci.

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Aging cognitive decline has been associated to impairment of the Hypothalamus Pituitary Adrenals (HPA) axis activity and a higher level of the systemic inflammation. However, little is known about the molecules driving this process at peripheral level. In addition, the cognitive function is to some extent modifiable with Memory Training (MT) programs, even among older adults and beyond. The study aims to evaluate whether MT could contribute to ameliorate cognitive performance and modulate the HPA axis activity as well the low level inflammation in the aging phenotype. Whether the phosphatase WIP-1, a negative regulator for inflammation, is involved in this process was also investigated. We recruited 31 young adults (19–28, years of age) and 62 older adults aged over 60. Thirty-two older adults were submitted to 6-months of MT program (EG), and 28 older adults were no treated and used as Control Group (CG). Global cognitive functioning (MMSE score), verbal and visual memory, and attention were assessed at baseline (T0) and after 6-months (T1). At the same time, plasmatic level of Cortisol (C), IL-1β, IL-18, IL-6, and the expression of WIP-1 mRNA and protein in ex vivo Peripheral Blood Mononuclear Cells were analyzed in young adults at T0, as well in older adults at T0 and T1. Together, the results suggest that MT improves the global cognitive functionality, verbal and visual memory, as well as the level of attention. At the same time we observed a decrease of the plasmatic level of C, of the cytokines, and an increase of the expression of mRNA and protein of WIP-1. The analysis of correlations highlighted that the level of the mRNA of WIP-1 was positively associated to the MMSE score, and negatively to the C and cytokine levels. In conclusion, we purpose the MT as tool that could help support successful aging through the improving of memory, attention and global cognitive function performance. Furthermore, this approach could participate to maintain lower the peripheral levels of the C and pro-inflammatory cytokines. The WIP-1 as a potential new target of the pathophysiology of aging is theorized.

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C-reactive protein response to a vegan lifestyle intervention

Cited by 44 publications

References 17 publications

C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders

C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders

Reducing meat consumption: Identifying group-specific inhibitors using latent profile analysis

Memory Training Program Decreases the Circulating Level of Cortisol and Pro-inflammatory Cytokines in Healthy Older Adults

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