C-reactive protein levels in the serum of asthmatic patients

Fujita, Mutsuhiro; Ueki, Shigeharu; Ito, Wataru; Chiba, Takahito; Takeda, Masahide; Saito, Norihiro; Kayaba, Hiroyuki; Chihara, Junichi

doi:10.1016/s1081-1206(10)60620-5

Cited by 62 publications

(47 citation statements)

References 16 publications

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“…Our results confirmed the presence of low-grade systemic inflammation in asthma as shown previously [2,24,26,27]. Hs-CRP levels in serum and EBC were statistically significantly higher in asthmatics than in healthy controls.…”

Section: Discussionsupporting

confidence: 92%

“…Takemura et al [26] have revealed that in patients with steroid-naïve asthma, serum levels of hs-CRP increase, compared with healthy volunteers, and correlate positively with sputum eosinophilia and negatively with indices of pulmonary function. Fujita et al [27] suggest that serum hs-CRP levels could be a marker of atopic and nonatopic asthma. The authors show a significant correlation between serum hs-CRP and ECP levels, and they suppose that increased hs-CRP levels may be related to allergic, particularly eosinophilic, inflammation.…”

Section: Discussionmentioning

confidence: 99%

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Changes in High-Sensitivity C-Reactive Protein in Serum and Exhaled Breath Condensate after Intensive Exercise in Patients with Allergic Asthma

Ziętkowski¹,

Skiepko²,

Tomasiak-Lozowska³

et al. 2010

Int Arch Allergy Immunol

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Background: Exercise-induced bronchoconstriction (EIB) in asthmatics depends on the presence of allergic inflammation. This study was performed to assess the possible association of EIB with low-grade systemic inflammation, whose presence was revealed in asthmatic patients. Methods: The study was conducted in a group of 24 asthmatics (14 with EIB, 10 without EIB) and 8 healthy volunteers. Changes in serum and exhaled breath condensate (EBC) high-sensitivity C-reactive protein (hs-CRP) levels induced by intensive exercise were determined. Moreover, the possible correlation of these measurements with the results of other tests used in the diagnosis of asthma as well as laboratory tests commonly associated with asthma were investigated. Results: In asthmatic patients with EIB, a statistically significant increase in hs-CRP levels both in serum and EBC after an exercise test was observed. Twenty-four hours after the exercise test in the group of asthmatics with EIB, a statistically significant increase in exhaled nitric oxide (F_ENO), serum eosinophil cationic protein (ECP) concentrations and bronchial hyperreactivity to histamine was revealed. A statistically significant correlation between the maximum increase in hs-CRP levels both in serum and EBC after exercise and either baseline F_ENO and an increase in serum ECP or F_ENO 24 h after exercise in the group of asthmatics with EIB was revealed. Conclusions: We show that, as a result of intensive exercise leading to bronchoconstriction, an increase in serum and EBC hs-CRP occurs. Our observations could suggest that in asthmatic patients, as a consequence of exercise-induced bronchoconstriction, an intensification of low-grade systemic inflammation can be observed.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Changes in High-Sensitivity C-Reactive Protein in Serum and Exhaled Breath Condensate after Intensive Exercise in Patients with Allergic Asthma

Ziętkowski¹,

Skiepko²,

Tomasiak-Lozowska³

et al. 2010

Int Arch Allergy Immunol

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“…23 High-sensitivity CRP levels also have been used as surrogate marker of disease control in asthmatics, with lower levels indicating better disease control. 24 …”

Section: Discussionmentioning

confidence: 99%

Asthma Predicts Cardiovascular Disease Events

Tattersall

Guo

Korcarz

et al. 2015

ATVB

125

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Objectives To identify and characterize an association between persistent asthma and cardiovascular disease (CVD) risk in the Multi-Ethnic Study of Atherosclerosis (MESA). Approach and Results MESA is a longitudinal prospective study of an ethnically diverse cohort of individuals free of known CVD at its inception. Presence and severity of asthma were assessed in the MESA at Exam 1. Persistent asthma was defined as asthmatics using controller medications (inhaled corticosteroids, leukotriene inhibitors, oral corticosteroids) and intermittent asthma as asthmatics not using controller medications. Participants were followed for a mean (standard deviation) 9.1 (2.8) years for development of incident CVD (coronary death, myocardial infarction, angina, stroke, and CVD death). Multivariable Cox regression models were used to assess associations of asthma and CVD. The 6,792 participants were 62.2 (standard deviation 10.2) years old: 47% male (28% African-American, 22% Hispanic, 12% Chinese). Persistent asthmatics (N=156), compared to intermittent (N=511) and non-asthmatics (N=6125), respectively had higher C-reactive protein (1.2 [1.2] vs 0.9 [1.2] vs 0.6 [1.2] mg/L) and fibrinogen (379 [88] vs 356 [80] vs 345 [73] mg/dL) levels. Persistent asthmatics had the lowest unadjusted CVD-free survival rate of 84.1%, 95% confidence interval (78.9–90.3%) compared with intermittent asthmatics 91.1% (88.5–93.8%) and non-asthmatics 90.2% (89.4–91%). Persistent asthmatics had greater risk of CVD events than non-asthmatics (HR 1.6 [95% 1.01–2.5, p=0.040]), even after adjustment for age, sex, race, CVD risk factors, and anti-hypertensive and lipid medication use. Conclusions In this large multi-ethnic cohort, persistent asthmatics had a higher CVD event rate than non-asthmatics.

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“…Beside airway inflammation, several studies have indicated a positive relationship between asthma and increased CRP levels [12–17]. Recently, Fujita et al found that serum CRP levels might be related to asthma exacerbations [18]. …”

Section: Introductionmentioning

confidence: 99%

Sustained Elevation of Systemic Oxidative Stress and Inflammation in Exacerbation and Remission of Asthma

Mak

et al. 2013

ISRN Allergy

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Oxidative stress has been implicated in the pathogenesis of asthma. We aimed at investigating the biomarkers of oxidative stress, inflammation, and tissue damage in patients with asthma in acute exacerbation and remission. We recruited 18 asthmatics admitted to hospital with acute exacerbation and 18 healthy nonsmoking controls matched for age. We evaluated plasma levels of 8-isoprostane, C-reactive protein (CRP) and total matrix metalloproteinase- (MMP-) 9 by ELISA, and MMP-9 activity by zymographic analysis. Plasma levels of 8-isoprostane and CRP were significantly elevated in acute exacerbation and decreased in remission but remained significantly higher compared to healthy controls. The activities of pro-MMP-9 were also significantly higher in acute exacerbation and decreased in remission but remained significantly higher compared to healthy controls in parallel to plasma levels of total MMP-9. These data suggest that overproduction of MMP-9 along with highly elevated levels of oxidative stress and inflammation is implicated in asthma exacerbation and that measurements of these biomarkers can be a valid index in its management.

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C-reactive protein levels in the serum of asthmatic patients

Cited by 62 publications

References 16 publications

Changes in High-Sensitivity C-Reactive Protein in Serum and Exhaled Breath Condensate after Intensive Exercise in Patients with Allergic Asthma

Changes in High-Sensitivity C-Reactive Protein in Serum and Exhaled Breath Condensate after Intensive Exercise in Patients with Allergic Asthma

Asthma Predicts Cardiovascular Disease Events

Sustained Elevation of Systemic Oxidative Stress and Inflammation in Exacerbation and Remission of Asthma

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