C-Reactive Protein Levels Are Higher in Patients With Fusiform Intracranial Aneurysms: A Case-Control Study

Telles, João Paulo Mota; Rabelo, Ní­collas Nunes; Rosí, Jefferson; Teixeira, Manoel Jacobsen; Figueiredo, Eberval Gadelha

doi:10.1016/j.wneu.2020.11.042

Cited by 7 publications

(6 citation statements)

References 30 publications

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“…However, another recently published meta-analysis failed to confirm this association (Hu et al, 2020). Furthermore, a case-control study showed that levels of C-reactive protein (CRP), which is a well-established downstream molecule of IL6 signaling, were higher in patients with fusiform IA than controls (Mota Telles et al, 2020).With the increasing availability of summary data from genome-wide association studies (GWASs), new methods such as two-sample Mendelian randomization (MR) and linkage disequilibrium score (LDSC) regression have been widely used to determine the relationship between traits. In two-sample MR analysis, single nucleotide polymorphisms (SNPs) associated with the trait of interest (e.g., IL6) from one GWAS are used as instrumental variables.…”

Section: Introductionmentioning

confidence: 99%

Association of Interleukin-6 Signaling and C-Reactive Protein With Intracranial Aneurysm: A Mendelian Randomization and Genetic Correlation Study

Niu

Wang

2021

Front. Genet.

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Background and objectiveEvidence suggests that interleukin-6 (IL6) signaling is causally associated with aortic aneurysm independently of the effect of C-reactive protein (CRP). We aimed to explore the genetic overlap and associations between inflammation (IL6 signaling and CRP) and intracranial aneurysm (IA) risk.MethodsTwo-sample Mendelian randomization (MR) methods were used to assess the causal effects of soluble IL6 receptor (sIL6R) (n = 21,758) and CRP (n = 204,402) levels on IA (7,495 cases and 71,934 controls) risk using genome-wide association study summary data of European individuals. Cross-trait linkage disequilibrium score regression was used to estimate the genetic correlations of CRP (n = 400,094) with IA.ResultsMR analyses showed that circulating sIL6R and CRP levels were not associated with the risk of IA. The odds ratios based on the inverse variance-weighted method were 0.986 (0.950–1.023, p = 0.45) and 0.957 (0.846–1.084, p = 0.49) for sIL6R and CRP, respectively. MR analyses using data of ruptured and unruptured IA each showed no association. Linkage disequilibrium score regression showed that the genetic correlation between CRP and IA was 0.16 (SE = 0.04, p = 0.0003). The genetic correlation diminished after conditioning IA on blood pressure (0.07 ± 0.05, p = 0.16), smoking (0.02 ± 0.05, p = 0.65), or blood pressure plus smoking (−0.03 ± 0.05, p = 0.53).ConclusionUsing associated genetic variants as instrument variables, two-sample MR analyses showed no evidence that circulating sIL6R and CRP levels were associated with IA risk. Although a positive genetic correlation was found between CRP levels and IA risk, it was mainly driven by the shared genetic background of blood pressure and smoking with both CRP and IA.

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Section: Introductionmentioning

confidence: 99%

Association of Interleukin-6 Signaling and C-Reactive Protein With Intracranial Aneurysm: A Mendelian Randomization and Genetic Correlation Study

Niu

Wang

2021

Front. Genet.

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“…31 So, it was not surprising that an inflammation marker (CRP) was significantly associated with MIA occurrence in the current study, as others have found for IAs in general. 32 Altogether, the correlation of PLT count with presence of MIAs must be interpreted with caution. Nevertheless, our results support a few previously published findings concerning PLTs and IAs in general.…”

Section: Discussionmentioning

confidence: 99%

Development of multiple intracranial aneurysms: beyond the common risk factors

Dinger

Oppong

Park

et al. 2022

Journal of Neurosurgery

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OBJECTIVE The prevalence of multiple intracranial aneurysms (MIAs) has increased over the last decades. Because MIAs have been identified as an independent risk factor for formation, growth, and rupture of intracranial aneurysms (IAs), a more profound understanding of the underlying pathophysiology of MIAs is needed. Therefore, the authors’ extensive institutional aneurysm database was analyzed to elucidate differences between patients with a single IA (SIA) and those with MIAs. METHODS A total of 2446 patients seen with or for IAs at the University Hospital of Essen, Essen, Germany, from January 2003 to June 2016 were included in this retrospective cohort study and were separated into MIA and SIA subgroups. Patient data were screened for sociodemographic and radiographic parameters, preexisting medical conditions, and results of blood examinations. These parameters were analyzed for their correlations with MIAs and absolute number of IAs. RESULTS MIAs were identified in 853 (34.9%) patients. In multivariable analysis, MIAs were independently associated with female sex (p = 0.001), arterial hypertension (p = 0.023), tobacco abuse (p = 0.009), AB blood group (p = 0.010), and increased admission values for C-reactive protein (p = 0.006), mean corpuscular volume (p = 0.009), and total serum protein (p = 0.034), but not with diagnostic modality (3D vs 2D digital subtraction angiography, p = 0.912). Absolute number of IAs was independently associated with female sex (p < 0.001), arterial hypertension (p = 0.014), familial predisposition to IA (p = 0.015), tobacco consumption (p = 0.025), increased mean corpuscular volume (p = 0.002), and high platelet count (p = 0.007). CONCLUSIONS In this sizable consecutive series of patients with IAs, the authors confirmed the impact of common IA risk factors on the genesis of MIAs. In addition, specific hemorheological and hemocytological features may also contribute to the development of MIAs.

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“…There are few studies demonstrating such associations. A study examining soluble IL-6 receptor and CRP levels to intracranial aneurysm risk showed no association despite other studies showing high CRP levels related to fusiform intracranial aneurysm presence and IL-6 polymorphisms related to intracranial aneurysm presence [16][17][18]. Additional cytokines have been examined in healthy patients with intracranial aneurysms, noting elevated levels of IL-1B, TNF-alpha, and MCP-1 in those with aneurysms [19].…”

Section: Discussionmentioning

confidence: 99%

Uncontrolled HIV and inflammation is associated with intracranial saccular aneurysm presence

Dugue¹,

Schnall²,

Liu³

et al. 2022

Aids

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Objective:To study biomarkers of inflammation in cerebrovascular disease, exploring modifiable and non-modifiable biochemical and clinical risk factors associated with the presence of intracranial saccular aneurysms (ISAs) in an HIV-positive cohort.Design:A cross-sectional community-based study was used to study blood biomarkers of inflammation as predictors of cerebrovascular disease, specifically the presence of ISAs in persons with HIV. Potential biochemical and clinical predictors of ISA presence were identified.Methods:Time of flight magnetic resonance angiography and magnetic resonance imaging data identified the presence of ISAs in an HIV-positive cohort. Quantitative assays for neuroinflammatory biomarkers were performed on plasma blood samples. Lasso regression models were used to identify neuroinflammatory biomarkers and clinical risk factors associated with ISAs.Results:Eight of 72 participants had radiographically identified ISAs. ISAs were more common in non-Hispanic black participants (18.5% vs. 0% presence in nonblack patients). Participants with well controlled HIV (defined as CD4+ count >200 cells/ml and undetectable viral load at time of magnetic resonance imaging) had lower odds of ISAs (odds ratio: 0.19, 95% confidence interval 0.05–0.79) independent of age, sex, ethnicity and vascular risk factors. Macrophage inflammatory protein-1 p, an HIV- suppressive factor detected in participant blood samples, was inversely associated with aneurysm presence.Conclusion:Well controlled HIV is associated with fewer ISAs. The identification of non-modifiable and modifiable risk factors contributing to ISA formation may provide valuable insight to impact clinical practice and inform the pathophysiology underlying ISA formation.

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C-Reactive Protein Levels Are Higher in Patients With Fusiform Intracranial Aneurysms: A Case-Control Study

Cited by 7 publications

References 30 publications

Association of Interleukin-6 Signaling and C-Reactive Protein With Intracranial Aneurysm: A Mendelian Randomization and Genetic Correlation Study

Association of Interleukin-6 Signaling and C-Reactive Protein With Intracranial Aneurysm: A Mendelian Randomization and Genetic Correlation Study

Development of multiple intracranial aneurysms: beyond the common risk factors

Uncontrolled HIV and inflammation is associated with intracranial saccular aneurysm presence

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