C-Reactive Protein Kinetics in Newborns: Application of a High-Sensitivity Analytic Method in Its Determination

Ishibashi, Midori; Takemura, Y; Ishida, Hideyuki; Watanabe, Kazuhiro; Kawai, Tadashi

doi:10.1093/clinchem/48.7.1103

Cited by 43 publications

(30 citation statements)

References 21 publications

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“…Our finding that the CRP values were higher in boys than in girls, also after adjusting for other factors, is in contrast with earlier studies . However, a sex difference may be plausible since similar sex differences have been reported for adults and since CRP levels have been found to correlate in various ways with levels of sex hormones .…”

Section: Discussioncontrasting

confidence: 99%

“…We have no definite explanation for the relationship between CRP concentrations and GA within a cohort born at term, but this finding is coherent with earlier studies , and we speculate that the reason may be increasing enzyme activity in the maturing liver or increasing stress with GA.…”

Section: Discussionsupporting

confidence: 72%

“…This hypothesis is in agreement with our findings since the effect of instrumental delivery disappeared when adjusting for duration of labour. Ishibashi et al and Chiesa et al showed that CRP levels increased with the duration of active labour, but they did not record the use of instruments during vaginal deliveries. We did not record tissue trauma, but CRP levels have not been associated with bruising or cephalhaematomas .…”

Section: Discussionmentioning

confidence: 99%

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Serum concentrations of C‐reactive protein in healthy term‐born Norwegian infants 48–72 hours after birth

et al. 2018

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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Serum concentrations of C‐reactive protein in healthy term‐born Norwegian infants 48–72 hours after birth

et al. 2018

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“…The cut-off value of serum CRP was between 1.5 and 20 mg/L, and its high sensitivity and specificity ranges (74-98%, 71-94%), as well as serial measurements, which are more valuable than single measurements, are its restrictive points. 32,33 In this study, in line with the EMA 2010 consensus suggestions, the cut-off value was accepted as 1.5 mg/dL for the serum CRP and the serum CRP values were above this value in both groups included in the study. Monitoring serial CRP values, and detecting bacterial infection are important for evaluating the response to treatment in infected patients.…”

Section: Discussionmentioning

confidence: 88%

Diagnostic Value of Urine sTREM-1 and Urine C-reactive Protein for Infants with Late Onset Neonatal Sepsis

Özdemir

Çolak

Ergon

et al. 2019

J Pediatr Infect Dis

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Objective Noninvasive markers have been increasingly used as a diagnostic marker for sepsis detection and monitoring of the disease. The aim of this observational, prospective pilot study was to investigate the diagnostic performance of urinary soluble triggering receptor expressed on myeloid cells (sTREM-1) and urine C-reactive protein (CRP) levels in the late onset neonatal sepsis and to compare them with serum CRP levels. Materials and Methods Sixty-six infants with clinical sepsis were included. Urine sTREM-1 and urine CRP were collected at the diagnosis of late-onset sepsis. All laboratory investigations were also noted from the infants. Results There were no significant differences between characteristics of the infants. Culture-positive neonates had significantly higher urine sTREM-1 than culture-negative neonates (p < 0.001). Using a cut-off point for urine sTREM-1 of 129 pg/mL, the sensitivity was 0.63, the specificity was 0.84, positive predictive value was 0.80, negative predictive value was 0.70. Urine sTREM-1 and urine CRP were recollected on the seventh day of sepsis treatment and it was found that the levels of sTREM-1 and CRP decreased. Conclusion This is the first study in the literature which evaluates the place of urine sTREM-1 and urine CRP in the diagnosis of neonatal sepsis. Urine sTREM-1 and urine CRP may be useful in the diagnosis of sepsis and in evaluating the effect of antibiotic treatment.

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“…1) There have been few reports on continuous evaluation of the CRP value in neonates from immediately after birth. [1][2][3][4] However, these few reports were of term infants. The CRP value fluctuated daily after birth in the ELBW as well as term infants, and temporary increases were also observed.…”

mentioning

confidence: 99%

C-reactive protein in extremely low birth weight infants using evanescent wave immunoassay to make normative standards after birth

Furukawa

Miwa

Hokuto

et al. 2010

Pediatrics International

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We evaluated CRP in ELBW up to 7 days old using the evanescent wave immunoassay (EVIA). EVIA is a high-sensitive CRP assay method capable of measuring CRP over 4 mg/dL with an interval of 0.1 mg/dL. This system is not influenced by bilirubin, hemoglobin, or lipid. The assay can be performed with 50 mL of whole blood, and the assay time is 10 min.The subjects were 108 ELBW infants born in our NICU between January 2002 and July 2008. Neonates who died within 1 month, those who were transferred to another hospital, those with chromosomal anomalies or congenital malformation, and those who underwent exchange transfusion were excluded. Those infants who exhibited symptoms suggestive of inflammation including fever, oliguria, hypotension, and frequent apnea, those with grade III-IV intraventricular hemorrhage, those with tension pneumothorax, those with necrotizing enterocolitis, and those with required surgical treatment, the data obtained until the day before the diagnosis were used. Those who showed no symptom of infection but were administered antibiotics prophylactically until negative blood cultures were confirmed were not excluded. Written parental informed consent was obtained before this study. Clinical information was collected retrospectively by examining medical records. Blood was collected daily between days 0 and 7 from the ELBW infants. CRP was measured by EVIA using EVANET EV20 (Nissui Pharmaceutical Corporation, Tokyo, Japan). Standard curves employing 50, 90, 95 percentile values were prepared from the accumulated data using Microsoft Excel.Standard values were obtained from the data of 85 of the 108 ELBW infants. The median gestational age of the 85 infants was 27 weeks and 4 days, the median birth weight was 800 g and male-female ratio was 33:52. The median Apgar score at 5 min was 6. Seventy-four infants were born by cesarean section. A transient, increase in CRP was observed in the ELBW infants as in the term infants. (Fig. 1) There have been few reports on continuous evaluation of the CRP value in neonates from immediately after birth. 1-4 However, these few reports were of term infants. The CRP value fluctuated daily after birth in the ELBW as well as term infants, and temporary increases were also observed.It is well known that maternal serum CRP does not shift across placenta. 5 The results obtained are useful for the early detection of bacterial infections and avoidance of unnecessary antibiotic therapy in ELBW infants. References

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C-Reactive Protein Kinetics in Newborns: Application of a High-Sensitivity Analytic Method in Its Determination

Cited by 43 publications

References 21 publications

Serum concentrations of C‐reactive protein in healthy term‐born Norwegian infants 48–72 hours after birth

Serum concentrations of C‐reactive protein in healthy term‐born Norwegian infants 48–72 hours after birth

Diagnostic Value of Urine sTREM-1 and Urine C-reactive Protein for Infants with Late Onset Neonatal Sepsis

C-reactive protein in extremely low birth weight infants using evanescent wave immunoassay to make normative standards after birth

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