C-reactive Protein in the Differentiation of Pyometra From Cystic Endometrial Hyperplasia/Mucometra in Dogs

Fransson, Boel A.; Karlstam, E.; Bergström, Annika; Lagerstedt, Anne-Sofie; Park, Jean S.; Evans, Marc A.; Ragle, Claude A.

doi:10.5326/0400391

Cited by 74 publications

(99 citation statements)

References 24 publications

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“…7,8,13,15,18,30 However, the contribution of chronic or recurring inflammation in the pathogenesis of renal disease in dogs is not well understood. Furthermore, it is not known whether serum CRP can be used as a diagnostic or prognostic marker of canine renal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…6,9,32 In dogs, several studies have described increased levels of serum CRP in response to a variety of pathological conditions, including infectious diseases, traumata, surgery, systemic inflammatory response syndrome, or immunemediated diseases. 7,8,13,15,18,30 Thus, serum CRP has been suggested as a major acute phase protein in dogs, and its measurement may contribute significantly to the detection, prognosis, and/or monitoring of the underlying disease. 9 Recently, CRP was also detected in urine samples obtained from dogs with chronic renal disease.…”

Section: Introductionmentioning

confidence: 99%

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C-reactive protein concentrations in serum of dogs with naturally occurring renal disease

2011

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The current study was undertaken to investigate the relation between serum C-reactive protein (CRP) concentrations and parameters of renal function in dogs with naturally occurring renal disease. Dogs were assigned to groups according to plasma creatinine concentration, urinary protein-to-creatinine ratio (UP/UC), and exogenous plasma creatinine clearance (P-ClCr) rates. Group A (healthy control dogs; n = 8): non-azotemic (plasma creatinine <125 µmol/l) and nonproteinuric (UP/UC <0.2), with P-ClCr rates >90 ml/min/m2; group B (n = 11): non-azotemic, nonproteinuric dogs with reduced P-ClCr rates (50–89 ml/min/m2); group C (n = 7): azotemic, borderline proteinuric dogs (P-ClCr rates: 22–67 ml/min/m2); and group D (n = 6): uremic, proteinuric dogs (not tested for P-ClCr). The serum CRP concentrations were measured via commercial enzyme-linked immunosorbent assay. The CRP concentrations in the clinically healthy dogs (group A) ranged from 2.09 mg/l to 8.60 mg/l (median: 3.21 mg/l). In comparison with dogs of group A, median CRP concentrations were significantly ( P < 0.01) elevated in dogs of group B (17.6 mg/l, range: 17.0–19.2 mg/l), group C (24.8 mg/l, range: 18.0–32.5 mg/l), and group D (59.7 mg/l, range: 17.7–123 mg/l). Serum CRP was significantly related to P-ClCr ( r = –0.83; P < 0.001), plasma creatinine ( r = 0.81; P < 0.001), UP/UC ( r = 0.70; P < 0.001), and leukocytes ( r = 0.49; P < 0.01). The significant relations between serum CRP concentrations and biochemical parameters of kidney function in plasma and urine suggest that a stimulation of the acute phase response is implicated in the pathogenesis of canine renal disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

C-reactive protein concentrations in serum of dogs with naturally occurring renal disease

2011

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“…The blood concentration of CRP is known to be elevated 100-to 1000-fold within 24-48 hr after inflammatory irritation, and it is broadly used as a sensitive inflammatory marker in human medicine. Similarly, the CRP concentration is known to be elevated in canine patients with inflammatory conditions, and its elevation has been reported in infectious diseases such as leptospirosis, babesiosis, and parvovirus infection [5]; surgical trauma [6]; malignant tumors such as lymphoma and hemangiosarcoma [12,18]; pyometra [8]; acute pancreatitis [11]; immunemediated hemolytic anemia; arthritis; glomerulonephritis [13]; and experimental inflammation. However, in veterinary medicine, CRP levels have not been widely examined in routine tests, and there are no thorough studies concerning CRP concentration in disease.…”

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confidence: 99%

C-Reactive Protein Concentration in Dogs with Various Diseases

Nakamura

Takahashi

Ohno

et al. 2008

The Journal of Veterinary Medical Science

149

186

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ABSTRACT. To investigate the clinical utility of C-reactive protein (CRP) determination in dogs, its plasma concentration was measured by a laser nephelometric method in 928 dogs with various diseases, and was compared with other inflammatory parameters. CRP concentration was elevated in various inflammatory diseases, this was most frequently observed in cases with neoplastic and immune-mediated diseases. All cases of pyometra, panniculitis, acute pancreatitis, polyarthritis, and hemangiosarcoma showed significantly elevated CRP concentrations. On the other hand, the CRP concentration was elevated only in few cases of neurological diseases such as epilepsy, meningoencephalitis, and hydrocephalus and endocrine diseases such as hypothyroidism, hyperadrenocorticism, and diabetes mellitus. Only a weak correlation was observed between the CRP concentration and white blood cell (WBC) counts (r=0.44) but no correlation with band neutrophil counts. There was no correlation between the CRP and albumin concentrations, but a weak negative correlation (r=-0.40) when excluding chronic intestinal diseases and nephrotic syndrome, which can cause protein loss. Thus, CRP can be useful to detect inflammations that cannot be detected by WBC and, or band neutrophil counts, suggesting that the examination of CRP concentration is essential as routine diagnostic test. KEY WORDS: albumin, C-reactive protein (CRP), canine, neutrophil, WBC.

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“…Additionally, CRP concentration in combination with Figure 3. Overview of C-reactive protein, haptoglobin and serum amyloid A concentrations in pyometra in bitches [3,10,29,30,32,34] the percentage of band neutrophils was useful to differentiate between pyometra and cystic endometrial hyperplasia. CRP showed 97.7% sensitivity and 75% specifi city in predicting the presence of pyometra [34].…”

Section: Dogsmentioning

confidence: 99%

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

Schmidt

Eckersall

2015

Acta Veterinaria

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During the acute phase response, there is an increased production and release of certain proteins known as acute phase proteins (APPs) which can be produced by hepatocytes and peripheral tissues such as C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), alpha-1 acid glycoprotein (AGP). These proteins have been investigated as markers of various infectious diseases in small animals and the purpose of this review is to update the current knowledge about APPs in infectious diseases in dogs and cats.

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C-reactive Protein in the Differentiation of Pyometra From Cystic Endometrial Hyperplasia/Mucometra in Dogs

Cited by 74 publications

References 24 publications

C-reactive protein concentrations in serum of dogs with naturally occurring renal disease

C-reactive protein concentrations in serum of dogs with naturally occurring renal disease

C-Reactive Protein Concentration in Dogs with Various Diseases

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

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