C-reactive protein in patients with aggressive periodontitis

Myšák, Jaroslav; Podzimek, Štěpán; Vašáková, Jana; Mazánek, Jiří; Vinsu, Alex; Dušková, Jana

doi:10.1016/j.jds.2017.04.003

Cited by 12 publications

(8 citation statements)

References 22 publications

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“…One study ( 18 ) demonstrated that CRP levels increase with the severity of periodontitis. Cases of very progressive and extensive periodontitis are associated with higher CRP levels ( 12 , 13 , 15 , 19 - 21 ). As regards periodontal therapy, however, intervention studies show discrepancies whether periodontal treatment has an impact on the reduction of serum CRP levels ( 14 , 15 , 21 - 23 ).…”

Section: Discussionmentioning

confidence: 99%

Association between periodontitis and serum c-reactive protein levels

et al. 2020

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Background Periodontal disease may be associated with more bacteria and consequent induction of a systemic inflammatory process, with changes in the levels of C-reactive protein (CRP). The purpose of this cross-sectional study was to evaluate the association between periodontitis and serum levels of C-reactive protein. Material and Methods The sample comprised 100 individuals distributed into two groups according to serum levels of C-reactive protein: normal or altered. Social, biological and behavioral data were collected by means of a structured questionnaire. Additionally, a blood test was requested to measure C-reactive protein levels. CRP values less than 3 mg/l were considered normal. Periodontal clinical examination was conducted in each participant for analysis of probing depth, bleeding on probing and clinical attachment level. Descriptive statistics, univariate analysis and logistic regression were performed. Results were provided in odds ratio, confidence intervals and p values. Results Individuals with altered C-reactive protein levels showed a higher prevalence of periodontitis than individuals with normal C-reactive protein levels ( p =0.008). In the final logistic regression model, individuals with periodontitis were more likely to present altered C-reactive protein than individuals without periodontitis (OR=3.27, CI=1.42-7.52, p =0.005). Conclusions The alteration of the C-reactive protein levels among individuals with a higher prevalence of periodontitis corroborates clinical evidence that periodontal infection has a systemic impact. Key words: C-reactive protein, cytokines, periodontal diseases, periodontitis.

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Section: Discussionmentioning

confidence: 99%

Association between periodontitis and serum c-reactive protein levels

et al. 2020

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“…In parallel, bleeding gums are a recognized keystone sign of oral inflammation with systemic impact [20,62,63]. There is evidence of a strong association between BoP and serum biomarkers of inflammation in populations with different CV risk [64,65].…”

Section: Discussionmentioning

confidence: 99%

Active gingival inflammation is linked to hypertension

Pietropaoli

Monaco

D’Aiuto³

et al. 2020

Journal of Hypertension

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Background. Cardiovascular diseases (CVD) including hypertension, are characterized by underlying systemic inflammation. Periodontitis which can impact the systemic inflammatory burden has recently been linked to high blood pressure (BP). However, the relationship of gingival bleeding, as an easily accessible marker of periodontal pathology, with hypertension, remains unclear.Methods. Survey-based propensity score matching (PSM) incorporating major confounders shared between hypertension and periodontal diseases was applied to cross-sectional NHANES III data from 5.396 adults ≥30 years who underwent BP measurement and periodontal examination, identifying two matched groups with and without gingival bleeding. The association of bleeding gums with systolic BP (mmHg) and high/uncontrolled BP was then assessed with generalized additive models incorporating inflammatory markers. Stratification by periodontal status (healthy; gingivitis; stable periodontitis; unstable periodontitis) was performed. Variables importance was estimated using machine learning.Results. Gingival bleeding (gingivitis; unstable periodontitis) was independently associated with +2.6 mmHg (p<0.001) systolic BP compared with no bleeding (healthy periodontium; stable periodontitis), and with greater odds (OR=1.42; 95%C.I.=1.19-1.68; p<0.001) of high/uncontrolled BP. Participants with unstable periodontitis had higher systolic BP than those with stable periodontitis (+2.1 mmHg; p<0.001) or gingivitis (+5.3 mmHg; p<0.001). Unstable periodontitis and gingivitis were consistently associated with increased risk of high/uncontrolled BP (OR=1.65, 95%C.I.=2.14-1.82; OR=1.49, 95%C.I.=1.22-1.82, respectively). Inflammatory markers allowed a maximum of 12% gain in the models' predictive power. Conclusions.Gingival bleeding contributes to shaping the relationship between periodontal diseases and BP, but the burden represented by periodontitis is also crucial. Periodontal evaluation might be of importance in difficult to control hypertension.

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“…Asimismo, es capaz de predisponer a la enfermedad vascular debido a la abundancia de especies Gram negativas involucradas, los niveles fácilmente detectables de citocinas proinflamatorias, infiltrados inmunes e inflamatorios aumentados, la asociación de fibrinógeno periférico y recuentos de glóbulos blancos, así como la extensión y cronicidad de esta enfermedad. (Kinane, 1998;Mysak et al, 2017).…”

Section: Introductionunclassified

Modelos de autoreportes para detección de enfermedades periodontales

Russell-Hernández

Campillo

Nachón-García

2021

UVserva

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Introducción: La enfermedad periodontal es una de las patologías infecciosas más prevalentes. El autorreporte es eficaz para evaluar características poblacionales, factores de riesgo y enfermedades. Por su rentabilidad, son prometedores como alternativa a las medidas periodontales clínicas en poblaciones donde pueden ser imprácticas o tener costos inaccesibles. Objetivo: Analizar artículos especializados para establecer la efectividad de los modelos de autorreporte como diagnóstico preliminar periodontal. Método: Búsqueda de artículos en inglés y español, en cuatro bases de datos indexadas utilizando modelo PICO y flujo PRISMA. Discusión: El autorreporte es una herramienta útil que puede implementarse en salud pública. Las medidas de autoinforme no reemplazan al examen bucal completo para diagnosticar periodontitis, pero pueden ser útiles en el seguimiento y vigilancia de condiciones periodontales en poblaciones. Conclusión: Los autocuestionarios muestran potencial para detectar enfermedad periodontal en estudios epidemiológicos, siendo un valioso recurso para vigilancia e implementación de políticas en salud pública.

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C-reactive protein in patients with aggressive periodontitis

Cited by 12 publications

References 22 publications

Association between periodontitis and serum c-reactive protein levels

Association between periodontitis and serum c-reactive protein levels

Active gingival inflammation is linked to hypertension

Modelos de autoreportes para detección de enfermedades periodontales

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